PURPOSE: Restenosis remains a frequent complication after angioplasty in peripheral arterial disease. Inflammation plays a critical role in the vascular response to injury. Effective medical treatment to improve patency after angioplasty is still elusive. The aims of this prospective clinical study were to investigate changes in blood coagulation and inflammatory markers after angioplasty and their significance for restenosis. METHODS: Thirty-four patients with peripheral arterial disease underwent angioplasty of the iliac and superficial femoral arteries. Ten patients undergoing diagnostic angiography were included in the study as controls. Plasma levels of tissue factor, prothrombin fragment 1 + 2, D-dimer, P-selectin, C-reactive protein (CRP), and fibrinogen were analyzed before and after angioplasty. Patients were followed up with angiography after 6 months to assess restenosis. RESULTS: CRP was elevated the day after angioplasty (6.6 mg/l, p = 0.0001) and tended to peak after 1 week (11 mg/l, p = 0.09). There was a significant increase of D-dimer and P-selectin 1-4 hr after angioplasty (0.4 mg/l, p = 0.001 and 68 ng/ml, p = 0.05, respectively). None of the biochemical markers was a statistically significant predictor of restenosis. CONCLUSION: We have observed a much more prolonged inflammatory response than previously noted, but only minor changes in coagulation activity after angioplasty. The biochemical markers, before and after angioplasty, were not related to restenosis. Further studies are needed to delineate the molecular mechanisms behind these observations and their involvement in thrombosis and restenosis. If these pathways are further defined, improved treatment strategies, including antithrombotic treatments and statins, could be tailored to modulate postprocedural inflammation.

Aged↗

PubMedDate not supplied

Influence of the intraluminal thrombus in abdominal aortic aneurysms.

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Aortic Aneurysm, Abdominal↗

PubMedDate not supplied

The role of adenine nucleotides in the peripheral vasodilating effect of thrombin.

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Adenine Nucleotides↗

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Femoro-popliteal and femoro-distal bypass: a comparison between in situ and reversed technique.

The present report compares the in situ technique with that using the reversed vein for femoropopliteal bypass. In 1986 the in situ technique was introduced at our clinic as the preferred method for femoropopliteal bypass with the lower anastomosis below the knee or femorodistal bypass. Forty patients operated with the in situ technique were compared with an equal number of patients operated with the reversed technique 1983-1985. The two groups were comparable regarding concomitant cardiovascular and pulmonary disease, preoperative ankle-brachial index and level of distal anastomosis. Patency after 6 months was significantly higher (84%) for the in situ grafts compared to reversed veins (49%). The difference was mainly caused by a significantly higher patency for in situ grafts anastomosed to infrapopliteal arteries. Despite better patency rates in the in situ group limb salvage at 6 months was the same in both groups. Operating time was also similar in both groups. It is concluded that the in situ technique is superior to the reversed technique, at least in infrapopliteal reconstructions. The superior patency rate and the technical advantages without apparent disadvantages are the basis for the recommendation to use the in situ technique for femoropopliteal and femorodistal bypass.

Aged↗

PubMedDate not supplied

Thrombectomy and temporary arterio-venous fistula for ilio-femoral venous thrombosis.

Sixty patients operated for ilio-femoral venous thrombosis with thrombectomy and temporary arterio-venous fistula (AVF) were evaluated. Fifty-one thromboses occurred in women and 48 were left-sided. A triggering mechanism was found in most patients. Fifty per cent of the women were pregnant or in the immediate postpartum period, one third of all patients had a recent operation or trauma and in one third a hereditary disorder could be traced. Blood coagulation studies postoperatively revealed disorders in the coagulation or fibrinolytic systems in 34 of 47 investigated patients. At operation it was possible to open the iliac vein in 50 patients and 42 received a functioning AVF. The AVF was closed after 3 months. Forty-six patients have been followed from 6 months to 5 years with one or several of the following investigations: venous plethysmography, radionuclide venography or routine venography. At follow-up the iliac vein was judged to be patent in 29 patients, in 17 it was occluded and in 8 patients it was probably occluded. All patients over 50 years of age were among those with occluded veins as were 6 of 9 men. The best results were achieved in women operated during pregnancy or in the puerperium. Venous thrombectomy with temporary AVF is effective treatment for ilio-femoral venous thrombosis, particularly in younger females with an obvious precipitating cause e.g. pregnancy or delivery.

Adult↗

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Acute ischemia of the extremities in a metropolitan area during one year.

All acute extremity ischemias during one year (1980) in the greater Stockholm area (population 1.5 million) were evaluated. One hundred and thirty eight cases were found. The incidence figures varied from 0.4/100,000 in the age group 20 to 30 years to 182/100,000 in the ages above 90 years. 81% of the cases were classified as emboli and 19% as acute thrombosis. Over all mortality was 19.5%. In the embolism group mortality was 21%, amputation rate 28% and limb salvage rate 51%. Limb salvage rate was significantly higher in patients receiving heparin therapy (61%) as compared to those who received no heparin (32%). Delay of treatment also caused an increase in amputation rate. Patients with acute thrombosis had a lower mortality (12%) and an amputation rate of 42%. It is concluded that the results of acute extremity ischemia may be less favourable than previously reported when results from institutions not specialised in vascular surgery are also included. Among other possible factors explaining the high amputation rate may be the proportion of older patients.

Acute Disease↗