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Biomedical subjects

J Sutton

Publications and source records attributed to J Sutton.

At least 37 records · Page 2Linked to original sources

Spinal cord ischemia following surgery for aortoiliac occlusive disease.

A 70-year-old man had aortobifemoral bypass for severe aortoiliac occlusive disease. He developed spinal cord ischemia with anterior spinal artery syndrome. He had minimal recovery of muscle function, multiple postoperative complications, and 11 months postoperatively he died. Spinal cord ischemia is a rare and unpredictable complication of abdominal aortic surgery. It most often has occurred following surgery for aneurysm but can also occur after apparently routine surgery for occlusive disease.

Aged

Measurement of postoperative pericardial pressure in man.

Pericardial pressure was measured in 18 patients undergoing cardiopulmonary bypass for up to 10 days using a solid state transducer. Mean and phasic pericardial pressure wave forms were similar to those reported in animals. A wide range of mean pressure from 0 to 30 mmHg was recorded, and values of up to 20 mmHg were observed in patients whose postoperative clinical course was uncomplicated. Fluctuations in pericardial pressure during spontaneous and artificial respiration were small, suggesting that concomitant left ventricular diastolic pressure changes were mainly the result of alterations in diastolic filling. Relative ventricular and pericardial distensibilities were estimated from the ratio of the slopes of diastolic pressure with time, which showed that up to 25 per cent of left ventricular diastolic pressure was supported by the pericardium and 75 per cent by the myocardium. Measurement of pericardial pressure had clinical value in 2 patients in confirming and excluding the presence of pericardial tamponade.

Adolescent

Growth hormone in exercise: comparison of physiological and pharmacological stimuli.

This study was designed to compare the serum growth hormone (GH) response with quantified exercise to that obtained with other stimuli. In eight normal males, aged 21-24 yr, we studied the serum GH response to 20 min cycle ergometer exercise at 300, 600, and 900 kpm/min on three separate occasions and compared the results with those found during sleep, insulin hypoglycemia, arginine infusion, and L-DOPA. Exercise at 900 kpm/min and insulin hypoglycemia resulted in the greatest elevations in serum GH which were significantly greater than those found with sleep, arginine or L-DOPA. The 20-min exercise at 900 kpm/min represented 75-90% of the subjects' maximal oxygen uptake and is a suitable provocative test for GH secretion. As a screening test for pituitary GH reserve, exercise compares favorably with insulin hypoglycemia and is superior to sleep, arginine, and L-DOPA.

Adult