Search PubMed⌕ Search

Biomedical subjects

J Sugar

Publications and source records attributed to J Sugar.

167 records · Page 10Linked to original sources
PubMedDate not supplied

Anterior segment anomalies associated with the fetal alcohol syndrome.

Anterior segment anomalies were noted in eight children diagnosed as having the fetal alcohol syndrome. Peters' and Axenfeld's anomalies were among the specific defects noted. Four children have maintained clear corneal grafts. A teratogenic action of alcohol during a critical period of development of anterior chamber structures is suggested as an etiologic factor. It is proposed that the varied types and severity of abnormalities noted might result from differences in blood alcohol levels, timing of the insult, and genetic background of the fetus. The observation of various types of malformations thought to share a similar pathogenesis lends additional support to the assumption that there is an interrelationship among these types of congenital segment pathology.

Anterior Chamber↗
PubMedDate not supplied

Screening and pathological diagnosis of asbestosis and mesothelioma: a review.

X-ray screenings of workers employed in asbestos manufacturing in Hungary revealed 255 cases of asbestosis and 3 cases of malignant mesothelioma. The pathological diagnosis of asbestosis is not very difficult. The diagnosis of mesothelioma, however, is fraught with problems. To identify mesothelioma we use histochemical reactions with PAS diastase digestion and immunohistochemical reactions for cytokeratin, vimentin, and CEA. The PAS and CEA reactions are negative but the vimentin and cytokeratin are positive in mesothelioma. Cytogenetic and molecular genetic studies may contribute to the better understanding of the pathogenesis and, thus, open new perspectives in our understanding of mesotheliomas.

Asbestosis↗
PubMedDate not supplied

Assessment of ocular protection for racquetball.

We evaluated the ability of 11 commercially available eye guards (lensless and closed) and eight piano spectacles (varying in lens thickness and material) to prevent ocular trauma from racquetballs. A guard was judged to be effective if the lens or frame did not shatter or dislodge after a minimum of ten direct blows with a racquetball and if eye contact was prevented. All spectacles failed; either the lens or the frame shattered. Open eye guards permitted the ball to contact the eye or were themselves propelled into the eye. Three commercially available closed guards failed because their frames broke. Only four guards passed our criteria for effectiveness.

Athletic Injuries↗
PubMedDate not supplied

Preparation of pH-adjusted local anesthetics.

Characteristics of alkalinized local anesthetics are poorly described with regard to stability and precipitation. Current fixed-volume methods of alkalinization often result in unstable, precipitated solutions of unpredictable pH. We determined a stable, nonprecipitating, anesthetic mixture and used it in a randomized double-blind crossover study of 21 patients to evaluate alkalinized anesthetic solutions in reducing pain on injection. Our solution significantly reduced pain associated with retrobulbar injection (analysis of variance, P = .0362) but not that associated with Nadbath injection. Fixed-volume alkalinization is not recommended because complications can result with the use of precipitated anesthetics.

Anesthesia, Local↗