[Subcellular metabolism of E1SO4 in the rat kidney (proceedings)].
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Animals↗
Biomedical subjects
J Strutz
Publications and source records attributed to J Strutz.
Correlation of 3D MRI and clinical findings in the patients with sensorineural hearing loss and/or vertigo.
The aim of the study was to correlate clinical and magnetic resonance imaging (MRI) (3D CISS and MP-RANGE) findings in patients with sensorineural hearing loss (SNHL) and/or vertigo. We found a high correlation of MRI and symptoms (17 out of 18 patients, 13 out of 13, respectively) concerning detectability of tumors and acute labyrinthitis. In the case of labyrinthine fibrosis, the correlation between clinical and MRI findings was lower. In conclusion, high-resolution MRI is very suitable in patients with SNHL or vertigo caused by tumors or acute labyrinthitis.
Adolescent↗
The postnatal growth of cochlear nucleus subdivisions and neuronal somata of the anteroventral cochlear nucleus in the Mongolian gerbil (Meriones unguiculatus).
We have analysed the postnatal volume increase of the cochlear nucleus subdivisions from birth to senescence in the Mongolian gerbil. All subdivisions showed the most prominent growth in the 2nd week of life before the onset of hearing on day 12. After the onset of hearing, the dorsal and the postero-ventral portion of the cochlear nucleus showed only a moderate degree of further growth. The antero-ventral cochlear nucleus, however, almost doubled in volume after the onset of hearing, reaching a maximum in 4-month-old animals. In ageing gerbils, we observed a small but systematic reduction of the cochlear nucleus volume. To further assess which elements contribute to the growth of the antero-ventral cochlear nucleus after the onset of hearing, we analysed the somal size of the neurones. Before the onset of hearing, somal and volume growth were highly correlated. However, somata had reached an adult size by the onset of hearing. We conclude that the growth of the antero-ventral cochlear nucleus after the onset of hearing is due to changes in the neuropil.
Age Factors↗
Concentration of cephalosporins in tissues of the head and neck after parenteral infusion.
Cephalosporins are successfully used in the therapy of acute sinusitis, purulent parotitis, and lymphadenitis. Anti-infectious prophylaxis in major head and neck surgery may be performed with cephalosporins as first choice. For sufficient prophylaxis or therapy, an effective level of the antibiotic drug in the serum and tissue of the target organs is necessary. In a comparative investigation, we measured serum and tissue levels of three regions of the head and neck (parotid glands, paranasal sinuses, soft tissue of the neck) of the second-generation cephalosporins, cefuroxime and cefotiam, after a single parenteral infusion. Both antibiotics reach levels which are effective against bacteria typically causing spontaneous or postoperative infection of head and neck tissue. Effective levels of cefuroxime both at the investigated tissue sites and in serum are greater than those of cefotiam, and cefuroxime is eliminated from serum less rapidly. The pharmacologic data show that both drugs are suitable for therapy and perioperative prophylaxis of purulent head and neck infections, but various data indicate that there is an advantage in favor of cefuroxime.
Adult↗
Age-dependent effects of the onset of a conductive hearing loss on the volume of the cochlear nucleus subdivisions and the expression of c-fos in the mongolian gerbil (Meriones unguiculatus).
A monaural conductive hearing loss was induced by interrupting the chain of the middle ear ossicles on the right side in gerbils of four different age groups (P12-14, P20-21, P42 and P84). The volumes of the cochlear nucleus subdivisions and the number of cells that expressed immunoreactivity for c-fos after noise stimulation were determined on the left and right side in the deprived animals, and in undeprived control animals when they reached the age of 6 months. The anteroventral cochlear nucleus on the deprived side was reduced in volume when the deprivation started before the age of 3 months. The other cochlear nucleus subdivisions showed no systematic age-dependent reductions. The expression of c-fos in the dorsal cochlear nucleus appeared more resistant to a hearing loss, with deprivation being more effective in younger animals. c-fos expression was also dramatically reduced in the ventral cochlear nucleus, regardless of age at the onset of hearing loss.
Acoustic Stimulation↗
Will neoadjuvant chemotherapy affect the capacity of head and neck squamous cell carcinoma to bind neoglycoproteins?
Evidence is growing that the carbohydrate portion of glycoconjugates is not merely an inert structural addition to the protein or lipid background, but is involved in normal and altered physiological processes. Conjugation of the potentially bioactive carbohydrate ligand to an inert labeled carrier generates the tools to histochemically monitor the presence of sugar receptors like lectins in tissue sections. In head and neck squamous cell carcinoma endogenous lectins have been systematically characterized by a selected panel of conjugates of such synthetic probes. In this investigation we provide evidence that the antineoplastic agents carboplatin and 5-fluorouracil influence the expression of carbohydrate-binding receptors. In cases with a statistically significant alteration, an increasing loss of binding capacity from treatment cycle to cycle was observed in cytoplasmic areas. This means that the extent of binding of beta-N-acetyl-galactosamine, cellobiose, galactose, and sialic acid was affected. The pattern of diminished binding capacity in nuclear structures encompassed beta-N-acetyl-galactosamine, beta-N-acetyl-glucosamine, sialic acid as carbohydrate part of the neoglycoprotein. Thus, exposure to certain chemotherapeutic agents clearly influences the capacity of tumor cells to mediate protein-carbohydrate interactions. Concomitant with the elucidation of the functions of such an interplay the significance of this down-regulation will be apparent.
Binding Sites↗
Are ABH antigenic determinants on human outer ear canal epithelium responsible for Pseudomonas aeruginosa infections?
The outer ear canal expression of ABH human blood group antigens has been analyzed with a standardized routine histological procedure by monoclonal antibodies in the case of blood groups A and B, and a corresponding lectin in the case of blood group 0, respectively. In all 20 cases the blood groups were histochemically confirmed. Furthermore, Pseudomonas aeruginosa-specific inhibition experiments were performed with different sugar solutions as well as A-like substance incubating outer ear canal tissue sections with P. aeruginosa strain (No. 60) presenting lectin specificity for N-acetyl-galactosamine (GalNAc). P. aeruginosa lectins with GalNAc specificity apparently adhere to GalNAc as terminal blood group A determinant and indicate that patients presenting with blood group A may have a genetic predisposition to this form of otitis externa.
ABO Blood-Group System↗
Efferent innervation of the cochlea.
The origin of the efferent innervation of the cochlea was investigated in the guinea pigs. Horseradish peroxidase (HRP) was injected into the cochlea and transported to the brainstem by retrograde axonal transport of the efferent fibers, showing the origin of the crossed an uncrossed olivocochlear bundles of Rasmussen. HRP-labeled neurons were found in various nuclei of the superior olivary complex bilaterally. Ipsilateral to the injected cochlea ther were three times more cells than on the contralateral side. About 40% of the total number of labeled neurons, a remarkable quantity, occurred in the ipsilateral lateral superior olivary nucleus. Moreover, extraolivary origin of the efferent innervation of the cochlea could be demonstrated bilaterally in the ventral nucleus of the lateral lemniscus.
Animals↗
Acoustic and vestibular efferent neurons in the chicken (Gallus domesticus). A horseradish peroxidase study.
The origin of labyrinthine efferent fibres was investigated in the chicken. After injection of horseradish peroxidase (HRP) into the cochlear duct or into the ampulla of the horizontal semicircular canal, efferent neurons in the medulla oblongata were labelled by the granular reaction product of retrogradely transported HRP. Efferent vestibular neurons were found in the nucleus reticularis pontis caudalis bilaterally with more cells ipsilateral to the injection side, while efferent cochlear neurons could be demonstrated medial to the ventral division of the facial nucleus bilaterally with more neurons contralateral to the injection.
Animals↗
The origin of efferent vestibular fibres in the guinea pig. A horseradish peroxidase study.
The origin of efferent vestibular neurons was determined in the guinea pig by means of retrograde axonal transport of horseradish peroxidase. After injection of a horseradish peroxidase solution into the ampulla of the horizontal and anterior semicircular canal, efferent vestibular neurons labelled by the granular reaction product were found in the medulla oblongata bilaterally at two locations. The first is lateral to the genu of the facial nerve. It has a bilateral and symmetric origin. The second is the nucleus reticularis pontis caudalis. Here there were more labelled neurons contralateral to the injection site.
Animals↗