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J Strom

Publications and source records attributed to J Strom.

43 records · Page 3Linked to original sources
PubMedDate not supplied

Inhibition of ornithine decarboxylase activity decreases polyamines and suppresses DNA synthesis in human colonic lamina propria lymphocytes.

Ornithine decarboxylase (ODC) and the polyamines are essential for cell proliferation in a variety of cells including lymphocytes. In this study, we investigated the potential role of ODC and polyamines in human colonic lamina propria lymphocytes (LPL) compared to peripheral blood lymphocytes (PBL). Our results show that con A stimulation of LPL and PBL was associated with marked increases in ODC and polyamines. The specific inhibitor of ODC, alpha-difluoromethylornithine (DFMO), resulted in a complete inhibition of ODC activity and depletion of putrescine, spermidine and spermine levels. DFMO also suppressed DNA synthesis of LPL and PBL by up to 48% and 62% respectively. This antiproliferative effect was reversed by adding back the polyamines putrescine (1 mM), spermidine (10 microM) or spermine (10 microM) to the culture medium. We conclude that ODC and the polyamines are important for human LPL proliferation, and hence may play a role in human mucosal immune function.

Aged↗
PubMedDate not supplied

Pericardial tamponade complicating central venous catheterization in an infant with very low birth weight: the role of echocardiography in diagnosis and treatment.

A case involving an infant with very low birth weight in whom an umbilical venous catheter led to pericardial tamponade, a rare but commonly fatal complication, is reported. This is one of only six reported cases in which the infant survived such a complication. Usage of echocardiographically guided pericardiocentesis under similar circumstances has only been documented once before. In the case of this 2-week old infant (birth weight 495 g), prompt diagnosis and treatment using echocardiography resulted in his survival.

Cardiac Tamponade↗
PubMedDate not supplied

Unstable angina.

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Angina Pectoris↗