[Recurrent conjunctival tumor. Recurrence of a squamous epithelial carcinoma of the conjunctiva].
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Carcinoma, Squamous Cell↗
Biomedical subjects
J Strobel
Publications and source records attributed to J Strobel.
Comparison of space-maintaining capabilities of Healon and Healon GV during phacoemulsification.
PURPOSE: To determine whether Healon GV or Healon (both sodium hyaluronate products) maintains space better during phacoemulsification with intraocular lens (IOL) implantation. SETTING: Department of Ophthalmology, Friedrich-Schiller-University of Jena, Germany. METHODS: This double-blind, randomized clinical trial comprised 60 patients (30 Healon GV, 30 Healon) eligible for cataract surgery. Patients were evaluated 6 and 24 hours and 5 days postoperatively. A digital slide gauge mounted on an operating microscope was used to measure the distance between the iris and epithelial side of the cornea before surgery and before and after capsulorhexis. The distance between the anterior and posterior lens capsules (i.e., space in the capsular bag) was also measured before and after IOL insertion. The surgeon's objective opinion of the products was evaluated. RESULTS: The mean anterior chamber depth after capsulorhexis was significantly greater in the Healon GV than in the Healon group (P = .003). The mean distance between the anterior and the posterior lens capsules was significantly larger in the Healon GV than in the Healon group before and after IOL insertion. The subjective evaluation of space-maintaining capacity during surgery also favored Healon GV. Healon was considered easier to inject and remove from the eye. CONCLUSION: Healon GV had better space-maintaining capacity than Healon during cataract surgery with phacoemulsification and IOL insertion.
Aged↗
Influence of laser coagulation therapy on untreated fellow-eyes in severe nonproliferative diabetic retinopathy-spectrometric results.
PURPOSE: The aim was to examine the influence of laser treatment on untreated fellow-eyes. METHODS: The effectiveness of the laser photocoagulation was investigated in 24 patients with type II diabetes mellitus and severe nonproliferative diabetic retinopathy. Using a spectrometric technique, the measurements in the macula were performed one day before laser coagulation and on the day directly following laser treatment. Further investigations took place 14 days and 6 weeks later. RESULTS: One day after coagulation, the reflection of the untreated fellow-eyes was found to be significantly increased between 530 and 600 nm, compared to the same eyes before coagulation. However, 14 days and 6 weeks after laser treatment alterations in the untreated eyes were no longer detectable. CONCLUSION: The choroidal blood volume seems to be decreased not only in coagulated eyes, but also in untreated fellow-eyes, and, presumedly, the choroidal blood flow is improved. Considering the short duration of these effects, a therapeutic consequence is not supposed.
Adult↗
[Experiences with an isolation method for retinal S-antigen and interphotoreceptor retinoid-binding protein].
UNLABELLED: S-antigen (AgS) and interphotoreceptor retinoid-binding protein (IRBP) are two highly potent uveitopathogenic autoantigens of the retina frequently used to trigger autoimmune uveitis in animal trials. PURPOSE: The aim of this study was the simultaneous isolation of both proteins from bovine retina, additionally avoiding time-consuming dialysis and employing prepacked, commercially available cartridges. METHOD: Retina extract, obtained in the usual manner, was precipitated with ammonium sulfate. Both the desalting and the buffer exchange of dissolved precipitate were carried out using a Bio-Gel P6 column. Subsequent separation with Econo-Pac Q gave prepurified AgS and IRBP fractions. Further purification was realized predominantly with Econo-Pac Q, -HTP and -HIC (5-ml cartridges). RESULTS: AgS and IRBP were isolated in high purity (sodium dodecylsulfate polyacrylamide gel electrophoresis, silver stain) from bovine retina using prepacked cartridges with yields of approximately 0.25 (for AgS) and 0.15 (for IRBP) mg/g retina, respectively. DISCUSSION: The application of ready-to-use cartridges allows simultaneous isolation of AgS and IRBP in milligram amounts under simplified conditions. This approach might be of particular interest for small samples of retina.
Animals↗
Instantaneous frequency maps, dipole models and potential distributions of pattern reversal-evoked potential fields for correct recognition of stimulated hemiretinae.
Lateral hemifield pattern-reversal visual evoked potential (PVEP) field data were evaluated using potential distributions, dipole modelling and distributions of Hilbert transformation-based instantaneous frequency in order to determine the stimulated hemisphere. Twenty channel records were collected from 35 normal volunteers in two laboratories using similar stimulus conditions (11-20.5 degrees target, 60-75 min checks, 2/s reversal, 500 ms analysis epoch). P100 latency was determined in each average by the global field power maximum between 90 and 120 ms. Using the data from O1 and O2 at P100 latency, the stimulated hemisphere was identified by maximal potential or minimal instantaneous frequency on the stimulus-contralateral side, or, using the 20-electrodes data at P100 by the ipsilateral lateralization of the dipole model. Correct classification of the stimulated 70 hemiretinae was achieved by potential distribution in 44 cases, by dipole modelling in 54 cases and by instantaneous frequencies in 68 cases. Errors in the classification by potential distribution and dipole location were twice as frequent for decisions based on expected locations over the left than over the right hemisphere. This finding might be caused by the relatively larger size of the left occipital lobe. We conclude that a single value of instantaneous frequency which implies a massive data reduction can serve as a robust parameter for the characterization of the input conditions of hemifield PVEP (i.e. the stimulated hemiretina). It is more successful than potential distribution or dipole modelling, probably because instantaneous frequency incorporates considerably more information than the other two measures. It is suggested to explore instantaneous frequency as a parameter to recognize small retinal area stimuli in perimetry studies.
Adult↗
[Argon laser therapy of multiple eccrine cysts of sweat gland efferent ducts (eccrine hidrocystomas)].
BACKGROUND: Eccrine hidrocystomas are usually benign, solitary cystic tumors which are mainly treated by surgical measures. Treatment of the rare multiple lesions gets into difficulties because of complications. PATIENT AND METHODS: A 74-year-old woman showed multiple bilateral lesions on the eyelids. Histology revealed eccrine hidrocystomas. The lesions were treated by Argon laser. Laser parameters were as follows: 600-1000 microns spot size, 500-600 mW power, 0.1-0.2 s time. RESULTS: After 6 months follow up no recurrence of any of the tumors was observed. CONCLUSION: Argon laser proved to be successful to treat multiple eccrine hidrocystomas.
Aged↗
[Adaptive procedures for measuring arterial blood flow velocity in retinal vessels using indicator technique].
There are highly significant differences in the measuring results of arterial blood velocity between the indicator and laser-Doppler techniques (up to 800%). A new measuring procedure for the analysis of indicator dilution curves was developed based on indicator model and experimental results. The use of this new measuring procedure results in reduced mean systematic error between the indicator and laser-Doppler techniques to values around 10%. With the introduction of adaptive measuring arrays for the creation of indicator dilution curves and the application of adaptive algorithms for centering and spectral normalizing of the dilution curves, improved reproducibility can be expected.
Blood Flow Velocity↗
The shoulder-hand syndrome after stroke: a prospective clinical trial.
Shoulder-hand syndrome developed in 36 (27%) of 132 hemiplegic patients in a prospective study. Subluxation, paresis of the shoulder girdle, moderate spasticity, and deficits in confrontation visual field testing were the major risk factors. In a placebo-controlled, nonblinded trial, 31 of the 36 patients became almost symptom free within 10 days' treatment with low doses of oral corticosteroids. Shoulder joint capsules taken at autopsy of 7 patients showed signs of previous trauma of the affected shoulder. In the second part of this study on another 86 patients, early awareness of potential injuries to shoulder joint structures reduced the frequency of shoulder-hand syndrome from 27 to 8%. These clinical findings suggest that shoulder-hand syndrome in hemiplegia is initiated by peripheral lesions. A self-perpetuating vicious cycle may be established, followed by the clinical picture of a "reflex sympathetic dystrophy." In the majority of stroke patients, this clinical phenomenon seems to be preventable by avoiding shoulder trauma.
Adrenal Cortex Hormones↗
[Pre- and postoperative corneal topography after combined single suture and running suture in ECCE. An analysis using the video keratoscope].
In a prospective study with 45 patients undergoing extracapsular cataract extraction (ECCE) with implantation of posterior chamber lens, curvature measurements of the cornea by means of computerized videokeratoscope were taken postoperatively. Analysis of the corneal shape on color-coded topographic maps of astigmatism showed an hourglass-shaped formation in all patients with a main axis in the sense of general astigmatism. Within a 3-mm zone (optical zone) the steepest meridian in all eyes was 96.1 +/- 13.3 degrees with an astigmatism of +4.4 +/- 2.1 D (1st postoperative day). Postoperatively we found that 35.6% of the patients examined had irregular astigmatism that could not be corroborated by the readings from the Javal ophthalmometer. An irregular astigmatism, corneal topographic analysis reveals regions peripheral to the center with a peak corneal refractive power of +43.8 +/- 1.4 D. In contrast to the conventional methods (for example, Javal ophthalmometer, autokeratometer), computerized videokeratoscope analysis provides additional and useful information on the corneal topography after intraocular operations.
Aged↗
Effect of heparin surface modification of polymethylmethacrylate intraocular lenses on signs of postoperative inflammation after extracapsular cataract extraction. One-year results of a double-masked multicenter study.
PURPOSE: A heparin surface modified posterior chamber intraocular lens (IOL) was compared with a conventional polymethylmethacrylate (PMMA) IOL regarding postoperative complications caused by inflammation. METHODS: Five hundred twenty-four patients from 10 different centers were included in a parallel group, double-masked, multicenter study. RESULTS: The cumulative number of patients with inflammatory cellular deposits on their IOLs during the first postoperative year differed significantly in favor of the heparin surface modified group, with 29.8% of the patients having cellular deposits compared with 48.8% of patients in the control group. Cellular deposits were observed most frequently at 3 months after surgery, and the difference between the groups was most pronounced and statistically significant at this time. The same results were seen at 1 year, but the difference was not significant. The number of cellular deposits per patient, however, was significantly lower in the heparin surface modified group at 1 year. Cumulatively, there were significantly more patients with posterior synechiae in the PMMA group than in the heparin surface modified group during the 1-year follow-up. Complications were few and comparable between the groups. CONCLUSION: The results of this study indicate that heparin surface modification reduces the inflammatory response to PMMA IOLs.
Adult↗
[In vivo autofluorescence. Measurements of human crystalline lenses with cataract and normal findings after excitation with monochromatic light].
In 25 eyes with nuclear cataract, 18 eyes with posterior subcapsular cataract, 25 eyes with cortical cataract, and 23 eyes without any pathological lens changes, the maximal fluorescence intensity was determined after excitation with monochromatic light at 365 nm, 405 nm, 436 nm, and 485 nm. The coefficient of variation was smaller than 5%. All eyes with cataract underwent cataract surgery a few days after the fluorescence measurements. The fluorescence spectrometer, especially constructed for in vivo measurements, consists of a modified slit lamp (Zeiss 75 SL) and an optical multichannel analyser (OMA) for gauging the data. The clinical trial was undertaken to determine whether, considering the influence of age, there is a difference between the fluorescence intensities in eyes with the above named cataracts and noncataractous eyes. The data were analyzed to determine the effect of age upon fluorescence intensity for all excitation wavelengths in both cataractous and noncataractous eyes. Age had an influence on the fluorescence intensities for all four excitation wavelengths. Assuming that the influence of age was not dependent on the state of the lens, it was quantified for all measurements and an "age-corrected" fluorescence intensity was calculated. The statistical analyses of these "age-corrected" fluorescence intensities revealed a significant difference (P < 0.001) for all of the types of cataracts examined and for normal eyes. The cataract types examined and the normal eyes showed differences in their fluorescence feature. To assess the fluorescence intensities obtained after excitation with the wavelengths mentioned above, one must take into consideration the influence of age on the measurements.
Adult↗
[Measuring scattered light with the Opacity Lensmeter 701 in normal eyes and eyes with cataracts. Correlation between scattered light and cataract-induced vision loss].
In 50 eyes with nuclear cataract, posterior subcapsular cataract and cortical cataract and 34 normal eyes, the amount of scattered light was determined using the Opacity Lensmeter 701 to determine its accuracy in distinguishing between clear and cataractous lenses. Taking as a basis the manufacturer's statement that normal lenses show Opacity Lensmeter readings of less than 25 and that cataractous lenses show Opacity Lensmeter readings of more than 30, 94% of the nuclear cataract cases, 62% of the posterior subcapsular cases and 66% of the cortical cataract cases were identified as being pathologically opaque. Of the normal eyes, 88% had an Opacity Lensmeter reading of less than 25. Among the types of cataract examined, a significant linear relationship (P < 0.05) between visual acuity loss due to cataract and scattered light measurements could be found only in eyes with nuclear cataract, with the individual results heavily scattered around the linear regression. In the case of nuclear cataracts, measuring scattered light with the Opacity Lensmeter is suitable for making general statements on visual loss due to cataract for a whole group of patients. However, in individual cases the results can only be used together with other clinical examinations.
Adult↗
[Computerized videokeratoscopy. Indications for postoperative suture removal].
Twenty-three patients who had a high degree of postoperative astigmatism (3 D) after extracapsular cataract extraction were examined in a prospective study with a computerized videokeratoscope. Sutures were removed within the first 3 months postoperatively, and an examination with the videokeratoscope was performed at the same time. In addition, corneal power was measured with a keratometer for comparison. A comparative map demonstrating the change in corneal shape can be obtained by simple subtraction of the pre- and postoperative keratographs (color-coded topographical maps). Immediately after suture removal the corneal curvature was flattened in the steepest meridian (3 mm and 5 mm zone), resulting in an average net change in cylindrical refraction of -1.3 (+/- 1.7)D. The steepest meridian moved slightly in a counterclockwise direction (-5.79 +/- 29.4 degrees). The topographical analysis of all cases showed that suture removal along the steepest meridian reduced astigmatism by flattening the steepest meridian and steepening the flattest meridian. As the peripheral cornea becomes steeper, the central cornea flattens in a meridian. Morphologically, three different patterns were found. In 52% the reduction in astigmatism was "symmetric", in 21% it was "round", and in 26% it was "irregular". As a result of the study, a topographical model of the cornea will be given, showing the average net change in diopters power at various locations on the surface of the cornea. These results cannot be described by the use of ordinary keratometers.
Astigmatism↗
[Concentration of non-steroidal, anti-inflammatory topical agents in the aqueous humor].
In a prospective randomised study we tested two non-steroidal anti-inflammatory medications clinically in a group of 40 eyes. 20 eyes received topically administered indomethacin and another 20 flurbiprofen eyedrops. Before we started the planned extracapsular cataract extraction we performed a puncture of the anterior chamber and aspirated a small volume of anterior chamber fluid. We examined the concentrations of the applied drugs in the aspirated volume. The concentration of indomethacin is 7-9 times higher than that of flurbiprofen.
Administration, Topical↗
[Concentration of locally applied Indometacin eyedrops for the inhibition of prostaglandin synthesis in the eye].
Indomethacin is well known as local eye drug for the prevention of cystoid macular oedema. The concentration is 50 mg/5 ml. Another inhibitor of the prostaglandin synthesis is flurbiprofen; its concentration is 1.5 mg/5 ml. Indomethacin is a suspension and available in different concentrations dependent on the shaking procedure. We measured the concentration of indomethacin in one single eyedrop from a full bottle, half full and a nearly empty bottle. After correct shaking the concentration of indomethacin was between 48 and 53 mg/5 ml.
Indomethacin↗
[Quantitative studies of protein and cell concentrations in the anterior chamber in cataract surgery with therapy using steroidal and non-steroidal antiphlogistic drugs].
In a prospective, randomized double-blind study, the anti-inflammatory effects of indomethacin and flurbiprofen were examined. The operation performed was extracapsular cataract extraction. For the pre- and postoperative measurement, the Laser Flare Cell Meter was used. In 76 eyes the flare and cell concentrations were measured quantitatively. It was found that, dependent on the postoperative time interval, indomethacin is more effective in reducing post-operative inflammation than flurbiprofen.
Anterior Chamber↗
[Glare and contrast with diffraction intraocular lenses].
The quality of vision in patients with a diffractive multifocal intraocular lens was tested and compared to monofocal IOLs and to eyes with a beginning cataract. An automatic computer-assisted visual acuity and contrast-sensitivity test was used. Diffractive IOLs showed reduced contrast sensitivity in both dark contrast testing and bright contrast testing. The differences from monofocal IOLs were not statistically significant. Glare sensitivity was of the same degree in both IOL groups. In additional, visual acuity under reduced contrast conditions was measured at the Ocutrast with and without glare. There was no significant difference between IOL groups. The results obtained showed that contrast sensitivity with diffractive IOLs is not as good as with monofocal IOLs. In this study no significant differences were found.
Aged↗
[Stereotactic evacuation and early rehabilitation in space-occupying cerebral hemorrhage].
The choice of treatment in intracerebral hematoma remains controversial as long as there are no prospective, randomized trials from multiple centers. Recent experiences showed a lower mortality rate after stereotactic evacuation of intracerebral hematoma. However according to the present study (60 patients) the quality of survival and duration of hospital stay seems to be dependent on early and intensified rehabilitation and physiotherapy.
Cerebral Hemorrhage↗