Natural killer (NK) cell activity and lymphocyte proliferation to mitogens might to have diagnostic implications that will help to distinguish between benign and malignant lymphadenopathy in children. In addition, we suggest that NK activity and especially the lowering of NK activity after chemotherapy might be of prognostic value in NHL children.

Child↗

PubMedDate not supplied

[Changes of various organs in joint diseases].

In a review of organic changes of rheumatic diseases the more important changes of skeletal musculature, gastro-intestinal apparatus, kidneys, blood vessels and eyes are discussed. The paper is based upon investigations, publications and post-graduate activities of the Rheumatism Research Institute of Prague.

Acid Phosphatase↗

PubMedDate not supplied

Interleukin-2 activated cells from peripheral blood of patients with systemic lupus erythematosus.

The effect of recombinant interleukin-2 (IL-2) on proliferative and cytotoxic response of peripheral blood mononuclear cells (PBMC) was investigated in a group of 21 patients with systemic lupus erythematosus (SLE). There was a significant decrease in thymidine uptake of peripheral blood mononuclear cells when compared with controls. However, IL-2 induced cytotoxicity was not diminished and minimal frequencies of lymphokine-activated killer (LAK) cells precursors remained in the range of control group. These data provide an evidence about the dissection between proliferative and cytotoxic response of PBMCs to exogenous interleukin-2 in patients with SLE in vitro. The factors contributing to this effect and the clinical significance of these findings remains to be answered.

Adolescent↗

PubMedDate not supplied

Effect of recombinant interleukin-2 on peripheral blood mononuclear cells following antigen-specific bronchial provocation.

In a group of 18 patients with seasonal asthma and rhinitis acute bronchial provocation was performed with grass pollen antigens. Blood samples were taken before and 15 minutes after the maximal clinical response. Effect of recombinant interleukin-2 (IL-2) on peripheral blood mononuclear cells (PBMCs) by tritiated thymidine uptake method was investigated. T4 and T8 subpopulations were also evaluated before and after acute challenge. The patients had a significantly higher responsiveness of their PBMCs to IL-2 in vitro. After acute challenge there was a significant reduction of the IL-2 responsiveness as well as a decrease in percentage of T4 cells. These changes, however, poorly correlated with the degree of bronchial obstruction and with the dose of inhaled antigen.

Adult↗

PubMedDate not supplied

Effect of interleukin-2 on peripheral blood mononuclear cells in severely injured patients.

The effect of human recombinant interleukin-2 (IL-2) on the proliferative and cytotoxic response of peripheral blood mononuclear cells was analyzed in 12 severely injured patients. The in vitro proliferative response (measured from tritiated thymidine uptake) was normal during the first post-injury week, but rapidly decreased from the second week. The cytotoxic response to natural killer cell-resistant target T24 was likewise diminished from the second week. To clarify if the defect in cytotoxic response was due to numerical reduction of precursors or to reduced responsiveness, limiting dilution assay was introduced. No post-trauma reduction in precursor numbers was observed. These data collectively suggest that, in addition to impaired IL-2 production, there is an endogenous defect in IL-2 responsiveness. In the context of high incidence of septic complications, the observations may be clinically important.

Adolescent↗

PubMedDate not supplied

[Experiences with the treatment of disseminated lupus erythematosus with 6-mercaptopurine].

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Adolescent↗