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Biomedical subjects

J Strejcek

Publications and source records attributed to J Strejcek.

At least 37 records · Page 2Linked to original sources
PubMed1987

Effect of human recombinant interleukin-2 on cytotoxic response of peripheral blood mononuclear cells in melanoma patients before surgery.

Natural killer activity against K562 targets and recombinant interleukin-2 induced cytotoxicity to NK resistant targets (MEL-4 and T24) was investigated in 15 melanoma patients. Before elective surgery no differences in cytotoxic activities were demonstrated when compared with patients with colorectal adenocarcinoma and controls. No correlation with the depth of the melanoma lesion was observed. Numbers of precursors of IL-2 induced killers in melanoma patients were in normal range. In conclusion, no defects in non-specific NK and IL-2 induced behavior in peripheral blood of melanoma patients were found. Other factors, specific, non-specific, related or unrelated to the tumor side should be thus considered.

Cytotoxicity, Immunologic↗
PubMed1987

Depression in spontaneous cell-mediated cytotoxicity occurs during hemodialysis.

NK activity against K 562 target cells and the percentage of HNK-1+ lymphocytes in peripheral blood were evaluated in 24 patients on maintenance hemodialysis prior to and during post hemodialysis session. No difference was found in the NK activity of these patients before hemodialysis and normal subjects. On the other hand patients had a decreased number of HNK-1+ cells. During hemodialysis, the NK activity as well as the HNK-1+ cell count decreased. No correlation was found between these parameters and either the cause of end-stage renal disease or the duration of dialysis treatment. In addition no correlation was observed between NK activity and the number of HNK-1+ cells.

Adult↗
PubMed1986

[Interleukin 2].

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Humans↗
PubMed1984

Further evidence of immunomodulatory effects of cimetidine.

The immunomodulatory effect of cimetidine was demonstrated both on human lymphocytes in vitro and in an experimental mice tumour model. Cimetidine increased the incorporation of tritiated thymidine into peripheral blood lymphocytes of healthy donors after nonspecific stimulation with PHA and Con A in vitro. Cimetidine prolonged the survival of mice bearing the syngeneic ascitic lymphoma EL-4. It had no cytotoxic effect on cells of ascitic lymphoma EL-4 in tissue culture.

Adjuvants, Immunologic↗