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Biomedical subjects

J Stirling

Publications and source records attributed to J Stirling.

34 records · Page 2Linked to original sources
PubMed1991

Expressed emotion and early onset schizophrenia: a one year follow-up.

Key relatives of 33 first or early admission psychotic patients (mainly schizophrenics) were interviewed to determine household levels of expressed emotion (EE). The patients were followed up for 12 months from index admission, during which time 13 (39%) experienced psychotic relapse. There was no association between relapse rate and household EE, but correlations between individual components of EE and pre-morbid measures suggest that level of criticism may be related to less acute onset of index episode, greater elapsed time since first signs of illness, and poor adjustment in the realm of work/study. The results are discussed in the context of continuing uncertainties about the precise nature of the relationship between EE and relapse.

Adult↗
PubMed1989

Autistic children's ability to interpret faces: a research note.

Ten autistic children were compared with 10 non-autistic children matched for chronological age and performance IQ on two tests of finding the odd face out of a set of photographs of faces, two tests of labelling photographs of faces, and a test of labelling photographs of common objects. The autistic children were significantly worse than the non-autistic children at finding the odd person out and the odd facial expression of emotion out, and at labelling facial expressions of emotion. They did no worse than the non-autistic children at labelling upside down faces or at labelling objects. The results, which replicate the findings of Hobson (J. Child Psychol, Psychiat. 27, 321-342, 671-680, 1986; Communication, 20, 12-17, 1986) are consistent with other evidence for a specific perceptual abnormality in at least some children with autism, the nature of which is discussed.

Adolescent↗
PubMed1988

Localization of the pro-sequence within the total deduced primary structure of human beta-hexosaminidase B.

The beta subunit of beta-hexosaminidase (beta-N-acetylhexosaminidase, EC 3.2.1.52) is synthesized in the rough endoplasmic reticulum as a prepropolypeptide. After the loss of the signal peptide and formation of an enzymatically active dimer, the pro-enzyme is either secreted from the cell or transported into the lysosome for processing to its mature form. In order to characterize the early posttranslational events we have purified nearly 1 mg of pro-hexosaminidase B from the NH4Cl containing medium of fibroblasts derived from a patient with the infantile form of Tay-Sachs disease. The partial N-terminal sequence was mapped to a position 42 residues C-terminal to the first in-frame ATG (Met residue) and 79 residues N-terminal to the known mature N-terminus. This position corresponds to that predicted for the cleavage of a 17 amino acid signal peptide generated through the use of the third rather than the first in-frame ATG as the initiation site for protein synthesis.

Amino Acid Sequence↗
PubMed1985

[Not Available].

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Botany↗
PubMed1984

Detection of campylobacter by immunofluorescence in stools and rectal biopsies of patients with diarrhoea.

Rabbit antiserum, elicited by the intravenous injection of a strain of Campylobacter jejuni heated to 100 degrees C, cross reacted strongly with all other thermophilic campylobacters tested as well as with "C pyloridis" and could be detected by indirect fluorescence with labelled anti-rabbit serum. Antisera to formalin killed cells did not do so. The correlation of positive stool culture with positive immunofluorescence of stools and rectal biopsies from patients with diarrhoea was 70-80%. Some inconsistent, weak reactions showing differently shaped organisms have been seen with some strains of Bacteroides fragilis. Wolinella spp reacted weakly, but one strain of Vibrio cholerae tested did not. Other intestinal organisms, commensals, and pathogens tested were negative.

Animals↗
PubMed1982

[Not Available].

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Botany↗
PubMed1976

Cephazolin treatment of pneumonia in the elderly.

Cephazolin, a semi-synthetic cephalosporin for parenteral use, was evaluated in 39 elderly hospital patients. Thirty-three of these patients were seriously ill at the start of treatment, suffering from pulmonary infections. In the other six patients, the drug was used post-operatively as a prophylactic, and it was effective in all cases in preventing any subsequent infection. Cephazolin was very effective in the treatment of 27 of the severely ill patients; the primary pathogen was eradicated and there was good clinical improvement. In two patients the primary pathogens were resistant to cephazolin, and the antibiotic therapy was changed after sensitivities were known. Of four patients with Haemophilus influenzae infection, clinical cure was obtained in two. Cephazolin therapy was discontinued in one woman because she developed a rash. However, there were no major toxic effects of therapy in terms of hepatic, renal or haematological function. No patient complained of pain when the intramuscular therapy was given. A dose of 1 g IM twice daily was shown to produce consistently high serum concentrations. Thus, in the elderly, the advantages of cephazolin are its lack of nephrotoxicity even when diuretic therapy is being administered concurrently, its lack of pain on intramuscular injection, and its sustained concentrations in the blood and urine so that it only requires to be given twice daily. In vitro studies showed that cephazolin is more active than cephaloridine against hospital pathogens.

Aged↗
PubMedDate not supplied

Schizophrenia and expressed emotion.

Research on expressed emotion (EE) is considered in the historical context of writings about disturbed family communication patterns and schizophrenia. More recent findings about the interaction between EE and schizophrenic relapse and the relevance of these findings for both clients and their relatives/carers are also summarized. The author offers recommendations for developing programs that focus on the client's social skills deficits.

Communication↗
PubMedDate not supplied

[Saliunca].

The author by analyzing antique, medieval and later sources attempts to identify the often used Latin botanical term, 'saliunca'. Based mainly on philological data he concludes, that this popular and widely spread herb is identical with the Valeriana celtica L., the close relative of the well known tranquillant Valeriana officinalis L.

History, Ancient↗