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Biomedical subjects

J Stessman

Publications and source records attributed to J Stessman.

65 records · Page 4Linked to original sources
PubMed1980

Effects of subminimal inhibitory concentrations of Erythromycin, Clindamycin, and Pristinamycin on the penicillinase production of Staphlyococcus aureus.

The influence of subminimal inhibitory concentrations of erythromycin, clindamycin, and pristinamycin on the penicillinase production of Staphylococcus aureus was tested in 12 strains. Of the 36 experiments performed, 16 (44%) showed a lack of influence, 10 (28%) displayed an increase, and 10 revealed a decrease in penicillinase activity. The maximal effect produced was generally induced by concentrations ranging from 1/4 to 1/32 the minimal inhibitory concentration, irrespective of the susceptibility of the strain to the drug. In spite of the fact that the drugs are closely related, they sometimes produced opposite effects on the same strain.

Anti-Bacterial Agents↗
PubMed1978

Phenotypic variations in gentamicin-resistant isolates of Staphylococcus aureus.

Eight clinical isolates of Staphylococcus aureus showing high level resistance to seven aminoglycosides are described. The resistance did not appear to be due to enzyme inactivation. Possible mechanisms of this resistance are discussed. Resistant strains showed phenotypic variations in the form of different colonial morphology and biochemical activity.

Drug Resistance, Microbial↗
PubMed1978

Antiformaldehyde and anti-N-like antibodies in hemodialysis patients.

Seventy-one hemodialysis patients were tested for antibodies to red blood cell antigens; 19 of the 71 had been treated with formaldehyde-sterilized dialysis membranes. The sera of 3 (16%) of these 19 contained anti-N-like antibodies and those of 17 (89%) contained a second agglutinin specific for formaldehyde-treated red blood cells. Anti-N-like and "antiformaldehyde" antibodies appear to be serologically distinct. We suggest that residual formaldehyde in formaldehyde-sterilized dialysis membranes reacts with red blood cells to form an immunogen responsible for antiformaldehyde in patients treated with these membranes.

Antibodies↗
PubMed1977

Post partum renal failure due to progressive systemic sclerosis treated with chronic hemodialysis.

An unusual case of progressive systemic sclerosis with rapidly progressing renal failure after a successful delivery is described. The presenting syndrome was malignant hypertension. The blood pressure was refractory to the various therapeutic measures which were instituted, including hemodialysis. The patient, therefore, underwent bilateral nephrectomy, following which the blood pressure returned to normal, and she survived on hemodialysis for 17 months. To the best of our knowledge, the patient presented herein is the only reported case of this kind of fetal and maternal salvage.

Adult↗
PubMed1977

Error in recovery rate of aminoglycosides from uraemic sera.

The recovery rate of gentamicin and tobramycin from uraemic sera was between 50 and 70% using a bioassay method which gave a 90% recovery rate from normal sera. This difference was not seen with streptomycin or kanamycin. The recovery rate from uraemic sera could be raised to clinically acceptable levels of above 80% either by using a different assay medium or by preparing standard solutions in pooled uraemic sera.

Aminoglycosides↗
PubMedDate not supplied

Effectiveness of combined nifedipine and propranolol treatment in hypertension.

The long-term antihypertensive effect of combined nifedipine and propranolol therapy was assessed in an open trial in 26 hypertensive patients (19 men, seven women, mean age 53 years). On propranolol alone (160 to 240 mg/day), the patients' average sitting blood pressure was 192 +/- 5/114 +/- 2 mm Hg. Propranolol was continued in a fixed dose and nifedipine was added in a dose that was gradually increased from 30 to 90 mg/day to achieve blood pressure (BP) values below 160/95 mm Hg. Twenty-two patients remained on the combined regimen for 14 to 30 weeks. Their BP decreased to 136 +/- 3/84 +/- 2 mm Hg on an average daily dose of 59.5 mg nifedipine. Seventeen of the 22 subjects were subsequently treated sequentially with propranolol alone, combined therapy, and nifedipine alone, to assess the relative efficacy of each mode of therapy. The combined regimen was found to be more effective than either drug alone. Side effects occurred in 13 of 26 patients. Four dropped out 4 to 11 weeks after starting nifedipine because of either intolerable flushing (2), allergic rash (1), or headache (1). Nine subjects experienced mild reactions that were well tolerated. It is concluded that the combined use of propranolol and nifedipine is effective in the long-term treatment of moderately severe hypertension and offers an alternative therapeutic approach that deserves further evaluation.

Adult↗