Search PubMed⌕ Search

Biomedical subjects

J Stern

Publications and source records attributed to J Stern.

At least 145 records · Page 8Linked to original sources
PubMed1988

[Small intestine pouches as a therapeutic principle in stomach and large intestine replacement].

Small bowel pouches are being utilized in several versions as substitute reservoirs after total gastrectomy and after continence preserving proctocolectomy. Throughout the world, most frequently the pouch is formed by simple duplication of the gut. The principles of reservoir formation, the special functional requirement in the upper and lower GI-tract are delineated. Follow-up studies prove the successful use of gastric and ileoanal pouches.

Adenomatous Polyposis Coli↗
PubMed1987

[Pathophysiology and technical prerequisites for maintaining continence].

Restoration of gastrointestinal continuity following total colectomy in patients with ulcerative colitis or familial polyposis can be achieved by construction of an ileal pouch and ileoanal anastomosis. In the development of the surgical technique three problems have emerged: a) pull-through operation; b) construction of the reservoir; c) anatomy and physiology of the sphincter system. The function of the continence organ can be evaluated by means of manometric, electromyographic and volumetric tests. The success of this complex surgical procedure also depends on the characteristics of the individual patient.

Adenomatous Polyposis Coli↗
PubMed1987

Two years of intrauterine contraception with levonorgestrel and with copper: a randomized comparison of the TCu 380Ag and levonorgestrel 20 mcg/day devices.

IUDs releasing 20 mcg/day of levonorgestrel (LNg20) were in randomized trial together with the Copper T, model TCu 380Ag, in seven centers involving 2244 women. Two-year (25 months) gross cumulative pregnancy rates were 0.2 +/- 0.2 and 0.9 +/- 0.3 for the levonorgestrel and copper releasing devices, respectively (P greater than 0.05). There were no ectopic pregnancies in more than 1600 woman-years of use of each device. Removal rates for bleeding and/or pain or for medical reasons other than menstrual problems did not differ significantly between devices. Oligomenorrhea or amenorrhea prompted 10.7 per hundred (gross rate, 8.4 net rate) women using the LNg 20 IUD to request removal in the two-year period, significantly above the 0.2 per hundred rate among women with the Copper IUD (P less than 0.001). At the end of two years an estimated 59.4 per 100 women were continuing use of the LNg 20 IUD, and 67.5 per 100 (P less than 0.001) with the TCu 380Ag. This difference is almost wholly ascribable to a marked reduction in bleeding episodes and days among women using the LNg 20 device with concomitant removal of device. Hemoglobin rose an average of 0.5 g/dl (P less than 0.001) for this group whereas women using the TCu 380Ag experienced a decline of 0.2 g/dl compared with baseline values (P less than 0.001).

Adolescent↗
PubMed1987

Rat brain microvessel extracellular matrix modulates the phenotype of cultured rat type 1 astroglia.

Astroglia from immature rat cerebral white matter which were plated on the insoluble extracellular matrix (ECM) secreted by rat cerebral microvessel endothelial cells (RCMEC) and maintained in a defined medium were induced to become stellate and to express glutamine synthetase. These effects were not elicited by RCMEC-conditioned medium. ECM secreted by rat pleural mesothelium elicited a lesser proportion of stellate astroglia and did not induce glutamine synthetase.

Animals↗
PubMed1987

Development and experimental application of contact probe catheter for laser angioplasty.

A sapphire contact probe laser catheter was developed to increase the dimensions of tunnels created by laser angioplasty. The device consisted of a round sapphire probe (2.2 mm diameter) attached to an 8F catheter into which a 0.2 mm optical fiber was inserted with a tip maintained at 3 mm from the sapphire. The fiber was connected to a continuous wave neodymium yttrium aluminum garnet (Nd-YAG) laser. A saline perfusate was circulated through the catheter during laser emissions to prevent excessive heating of the fiber tip. The system was used in vitro on 16 sections of atherosclerotic calcified human cadaver aortic walls, using diluted blood as a medium, at powers ranging from 10 to 40 W and exposure times from 1 to 4 seconds. Six craters were created at each energy level. The system was also used on six human cadaver, agar-embedded, obstructed iliac and femoral arteries, using 40 W and 2 second laser emissions. Dimensions of probe-created craters were compared with those obtained using bare fibers. The shape of the probe craters was that of a truncated cone with the entry hole wider than the exit, as opposed to the cylindrical shape created with unmodified bare fibers. At 120 J (seconds X watts), areas of entry and exit probe-formed holes were greater than those created with the bare fibers (6.7 +/- 0.5 and 3.4 +/- 0.6 versus 0.2 +/- 0.01 mm2, respectively, p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Angioplasty, Balloon↗
PubMed1987

Recurrent psoas abscess.

Recurrence of a psoas abscess in exactly the same location is very unusual--in fact, we found no other reports in the literature. Laparotomy performed after the patient presented with the second abscess revealed an impacted calculus and diverticulitis of the appendix as the cause. Computed tomography was effective in establishing the diagnosis, but the question of the best method of treatment remains. Percutaneous drainage was insufficient in this case.

Abdomen↗
PubMed1987

Gastroparesis secondary to a medulloblastoma of the posterior fossa.

A patient with a 4-month history of unexplained nausea and vomiting is reported. The only abnormality found initially was severe gastroparesis found by gastric emptying scan. Subsequently, a posterior fossa tumor was found. The pathogenesis of this unusual presentation and the role of the gastric emptying scan is discussed.

Adult↗
PubMed1987

The biochemical approach to mental handicap: 30 years of achievements and disappointments.

In the past half century, biochemistry has emerged as an independent discipline that provides essential and fundamental information for medical science. It has an increasingly important role in various branches of medicine and the biochemist is frequently called upon to apply his expertise to the solution of clinical problems, amongst them the role of biochemical disturbances in the aetiology of disorders associated with mental handicap, and the investigation of factors affecting their severity and clinical course. The expectation has been that the understanding of biochemical defects will lead promptly to the suggestion of remedies.

Brain Diseases, Metabolic↗
PubMed1987

Sensitive homologous radioimmunoassay for human parathyroid hormone to diagnose hypoparathyroid conditions.

A sensitive radioimmunoassay for human parathyroid hormone (hPTH) to diagnose hypoparathyroid conditions is described. The antiserum was raised in goats against extracted hPTH. Synthetic human PTH fragment (53-84) is used as a standard and 125I-Tyr52hPTH (53-84) as a tracer. After a two-step incubation (24 h + 24 h) at 4 degrees C, the bound and free fractions are separated by a mixture of second antibody and polyethylene glycol solution. The detection limit for hPTH (53-84) is 2 pmol/L hPTH (53-84) (2 mol/tube). The PTH level in 36 healthy subjects was 5-12 pmol/L. Of 14 patients with hypoparathyroidism 11 patients had PTH concentrations below normal, two patients had levels on the lower limit of the normal range (5 pmol/L). The concentration of one patient with pseudohypoparathyroidism was markedly elevated. This assay is suitable for detecting low PTH levels and for studying changes of PTH concentration within the normal range.

Calcium↗
PubMed1986

Esophageal tear following forceful removal of an impacted oral-gastric lavage tube.

We report an unusual complication of oral-gastric lavage in a drug overdose patient. During the lavage procedure, the oral-gastric tube became impacted in the esophagus. Forceful removal of the tube resulted in an esophageal tear. The patient did well with conservative management and was discharged with no long-term sequelae.

Administration, Oral↗
PubMed1986

Incorporation of tritiated galactose into galactocerebroside by cultured rat oligodendrocytes: effects of cyclic adenosine 3',5'-monophosphate analogues.

Cells dissociated from the forebrains of 21-day-old rats were enriched in oligodendroglia by Percoll gradient centrifugation, seeded on polylysine-coated surfaces, and cultured in a serum-containing medium. Incorporation by the cultures of tritium from D-[3H]galactose into the galactosyl residue of galactocerebroside (galC) increased in an almost linear fashion for 48 h with 1-8 muCi of D-[3H]galactose (30 mCi/mumol) per milliliter medium. Treatment for 2 days (day 1-3 after seeding) with 10(-4) M or 10(-3) M dibutyryl cyclic adenosine 3',5'-monophosphate (db cyclic AMP) or 10(-4) M 8-bromo cyclic AMP stimulated galC radiolabelling. Incorporation of D-[3H]galactose into galC during a terminal 48-h radiolabelling period was not stimulated when the cells were continuously treated with these cyclic AMP analogues for 8 rather than 2 days.

8-Bromo Cyclic Adenosine Monophosphate↗
PubMed1985

The effect of nucleotides on the rate of spontaneous quantum bumps in Limulus ventral photoreceptors.

The effect of intracellular nucleotides on the rate of spontaneous quantum bumps in Limulus ventral photoreceptors has been examined. Internal dialysis of photoreceptors with solutions lacking nucleotide leads to an elevation of the quantum bump rate that can be reversed by introduction of nucleotide. Similarly, elevation occurs after treating intact cells with the metabolic inhibitor 2-deoxyglucose. This effect can be reversed by intracellular injection of ATP. The rate of spontaneous quantum bumps in unpoisoned cells can be reduced to below normal levels by injection of ATP. These results support the hypothesis that high-energy nucleotides suppress the rate of spontaneous quantum bumps.

Alkaline Phosphatase↗