Search PubMed⌕ Search

Biomedical subjects

J Stephenson

Publications and source records attributed to J Stephenson.

At least 289 records · Page 16Linked to original sources
PubMed1975

Serum gonadotrophins in young children.

LH and FSH were assayed in serum samples from children ranging from newborn to 13 years. In boys, LH was found in most samples up to 4 months of age, in many up to 10 months, but in only 38 percent between 1 and 8 years. In girls, it was found in only 29 percent of the samples under 1 year and the frequency and concentration changed little thereafter until 8-10 years. FSH was detected in all samples from boys up to 4 months and in most of those from girls up to 2 years. After these ages the frequency declined in each sex and there was little further change until 8-10 years. Between 1 and 8 years the proportion of samples containing either FSH or LH was similar for the two sexes, but whereas in boys high LH tended to be associated with high FSH, and vice versa, there was no such correlation in girls. The results are discussed in relation to gonadal development and steroid synthesis.

Adolescent↗
PubMed1973

Acute haemolytic anaemia associated with polyagglutinability of red cells.

A 7-week-old albino infant developed acute haemolytic anaemia following an operation for strangulated inguinal hernia. This was considered to be due to polyagglutinability of the red cells, the haemolysis subsiding as the cells returned to normal. The red cell changes were shown to be due to activation of T-antigen, reacting with anti-T in the adult blood transfused to the infant.

Absorption↗
PubMed1973

Evaluation of a tanned red cell technique for thyroid microsomal antibodies.

A haemagglutination test for thyroid microsomal (cytoplasmic) antibodies, using formolized tanned sheep red cells, is described and evaluated. The technique is essentially similar to the thyroglobulin tanned red cell test. It has been shown to be more sensitive and easier to use than the complement-fixation test. A combined screening test to detect both thyroglobulin and microsomal antibodies is described.

Animals↗
PubMed1970

L-dihydroxyphenylalanine: effect on S-adenosylmethionine in brain.

Forty-five minutes after intraperitoneal injection of a single dose (100 milligrams per kilogram) of L-dihydroxyphenylalanine, the concentration of S-adenosylmethionine in rat brain was lowered by 76 percent. As little as 10 milligrams of L-dihydroxyphenylalanine per kilogram decreased content of S-adenosylmethionine in the adrenal medulla by 51 percent, whereas 100 milligrams per kilogram did not significantly depress concentration of S-adenosylmethionine in the liver in this time interval. Concentration of S-adenosylmethionine in the brain varied diurnally; L-dihydroxyphenylalanine lowered this concentration whether administered at the daily peak or at the nadir.

Adrenal Medulla↗
PubMedDate not supplied

RAS gene mutations in Chinese leukaemia patients and members of a family with high incidence of leukaemia.

We investigated mutations of N-RAS and K-RAS by using polymerase chain reaction (PCR)-oligonucleotide hybridization techniques in 40 cases of Chinese leukaemia patients and 17 presently healthy members of a family with high incidence of acute myeloid leukaemia. The results showed only two patients carried the mutation in codon 12 of N-RAS. Strikingly, however, in both cases the malignancies involved lymphoid lineage. There was no hereditary RAS mutation in the members of the remarkable family.

Acute Disease↗