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Biomedical subjects

J Stein

Publications and source records attributed to J Stein.

At least 469 records · Page 26Linked to original sources
PubMed1976

Experience with the Small-Carrion penile prosthesis in the treatment of organic impotence.

Since certain animals are endowed with an os penis the concept of using penile implants was a natural development. Herein we report on our experience with the Small-Carrion penile prosthesis in 23 patients. The surgical technique is described as well as several examples of postoperative results. The major complication encountered was infection. All patients were able to accomplish coitus without significant difficulty. Proper patient selection and the attitude of the sexual partner constitute the major factors in the ultimate success or failure of the procedure.

Adult↗
PubMed1976

Dephosphorylation of nonhistone proteins specifically alters the pattern of gene transcription in reconstituted chromatin.

A nonhistone phosphatase devoid of detectable protease activity has been purified from nuclear sap by chromatography on DEAE-Sephadex. After linkage to an insoluble agarose matrix, this enzyme was used to dephosphorylate nonhistone proteins obtained from S-phase HeLa cells. Chromatin reconstituted with these dephosphorylated proteins exhibited roughly a 50% reduction in the overall number of initiation sites available for transcription when compared to controls. Specific measurements of transcription of histone genes with use of a complementary DNA probe showed that genes coding for histones are preferentially inhibited after nonhistone dephosphorylation. These results provide the first direct support for the theory that phosphorylation of nonhistone proteins is involved in regulating the availability of individual genes for transcription.

Cell Nucleus↗
PubMed1976

Visual cells in the pontine nuclei of the cat.

Two hundred and thirty-two visually activated neurones were recorded in a small area of the rostral pontine nuclei of cats. The location of visually activated neurones was coextensive with the input from visual areas of cat's cortex as determined by degeneration studies. 2. Pontine visual cells could only be driven by visual stimuli. Cells responsive to somatosensory or auditory stimuli were also found in different regions in rostral pontine nuclei. They too responded to only one modality. 3. 96% of the cells were directionally selective. 4. Pontine visual cells were responsive to a wide range of stimulus speeds. Some cells responded to targets moving as fast as 1000 degrees/sec without losing directional selectivity. No pontine visual cells gave a clearly sustained response to a stationary stimulus. 5. Exact stimulus configurations were not critical. Large fields containing many spots were the most effective stimuli for 50% of the cells. Inhibition of responses depending upon stimulus dimensions, direction of movement, or location in the visual field was found for many cells. 6. Receptive field dimensions were large, ranging in size from 3 degrees X 4 degrees to more than an entire hemifield. 7. 94% of the cells had receptive fields which were centred in the contralateral hemifield. 8. 98% of the cells could be driven from both eyes. 9. The properties of the pontine visual cells suggest a corticopontocerebellar pathway sensitive to a wide range of speeds and directions of movement, but not sensitive to precise form.

Action Potentials↗
PubMed1975

Regulation of cell cycle stage-specific transcription of histone genes from chromatin by non-histone chromosomal proteins.

RNA transcripts from chromatin of S phase but not G1 cells contain histone-specific sequences. Chromatin reconstituted with S phase non-histone chromosomal proteins transcribes histone messenger RNA sequences whereas chromatin reconstituted with G1 non-histone proteins does not. These results suggest that transcription of histone genes is regulated during the cell cycle and that non-histone proteins have a key role in this regulation.

Cell Division↗
PubMed1975

[Artificial respiration as treatment of postoperative complications after cardiovascular surgery: indication, technique, results (author's transl)].

From 1972 to 1974 524 patients underwent surgery with extra corporal circulation. 83 (15,8%) patients had to be postoperatively ventilated for a prolonged period or reintubed after a symptomfree interval due to anticipated or manifested complications. 31 (37%) out of these expired. There was no death due to the prolonged ventilation itself, shown by the group, in which the causes for the above treatment were others but respiratory failure or insufficiency. All patients of this group survived. Indications, technique and results are described and discussed.

Germany, West↗
PubMed1975

[Treatment of postoperative renal insufficiency after cardiovascular surgical procedures by peritoneal dialysis (author's transl)].

In 1972 and 1973 there have been 698 (351 with ECC) cardiovascular surgical procedures. 29 cases of renal insufficiency were seen in this group, 15 requiring peritoneal dialysis. There were only two survivors in the latter group. However none died due to renal insufficiency. The indication, technique, complications, results are discussed in detail.

Acute Kidney Injury↗
PubMed1973

Gonococcal arthritis: a report of six cases.

Six cases of gonococcal arthritis are described. Three presented during the initial "bacteremic stage" with polyarthralgia, fever, skin lesions and sterile synovial fluid. Two presented during the "septic joint stage" with positive synovial culture, and one presented during the "stage of residual deformity". Transient electrocardiographic changes were noted in two of the six cases. All responded to antibiotic therapy. One required additional surgical intervention.The condition is common, coinciding with the rising incidence of symptomatic and asymptomatic gonorrhea. Gonococcal infection must be considered in the differential diagnosis of migratory polyarthralgia, tenosynovitis, oligoarthritis, fever or unusual skin lesions. Criteria for diagnosis, lines of treatment and relevant literature are reviewed.

Adolescent↗
PubMed1972

Visual input to the pontine nuclei.

Visual input to the pons was studied by anatomical and physiological methods. Cortical area 18 sends a dense projection to the rostral pons. Pontine cells respond best to targets moving in a preferred direction over a large receptive field, which usually includes the center of gaze. The results suggest a role for pontocerebellar pathways in visual control of movement.

Action Potentials↗