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Biomedical subjects

J Steen

Publications and source records attributed to J Steen.

At least 19 recordsLinked to original sources
PubMed2000

Steroid hormone receptors and long term survival in invasive ovarian cancer.

BACKGROUND: Steroid hormone receptors are important determinants of prognosis and predictive behavior in tumor tissues of several origins. Since their role in ovarian cancer is still controversial, we investigated the prevalence and prognostic impact of the estrogen (ER) and progesterone (PR) receptors and combinations (ER+PR+, ER+PR-, ER-PR+, and ER-PR-) in a comparably large number of patients with a long clinical follow-up. METHODS: The present analysis included 186 patients with invasive ovarian carcinomas treated at the Department of Obstetrics and Gynecology of the Justus-Liebig-University Giessen between 1982 and 1996, the follow-up lasting up to 15.8 years (median 2.4 yrs). The expression of ER and PR was assessed by immunohistochemistry using alkaline phosphatase antialkaline phosphatase in microwave pretreated, formalin fixed, and paraffin embedded specimens of the primary tumors and was evaluated semiquantitatively using a standardized immunoreactive scoring system. Receptor expression and combinations were compared to clinical, histologic and prognostic factors, the tumor proliferation, and the clinical outcome. RESULTS: Kaplan-Meier survival analyses supported the favorable prognostic value of PR and its level of expression in ovarian carcinomas. Especially the ER-PR+ combination, which accounted for 10.2% of all tumors, showed a significantly superior prognosis when compared with all other combinations (survivors 15 of 19 vs. 67 of 167, log rank P = 0.009) and was associated with early stage, low ascites quantity, and higher tumor differentiation. Five-year survival rates were 13/16 (81.3%) for ER-PR+ tumors versus 58/128 (45.3%) for all other steroid hormone receptor combinations. Residual analysis proved the results. CONCLUSIONS: The determination of steroid hormone receptor status offers additional prognostic information in ovarian carcinomas. Especially the ER-PR+ phenotype predicts a favorable tumor biology and long term survival, probably reflecting functional effects on tumor proliferation, differentiation, and cellular apoptosis.

Female↗
PubMed1993

[Hereditary diseases and abnormalities as cause of death during the first 2 years of life among 7 groups of Oslo children. A comparison between Norwegian and Pakistani children].

Perinatal and infant death are important indicators of community health. We examined the rate of stillbirth and death before the age of two years among 36,700 children with Norwegian and 2,750 children with Pakistani background. There was no difference in the rate of stillbirth and death during the second year of life, but a 2.5-3 times higher death rate during the first year of life among the Pakistani children, compared with the Norwegian children. When deaths due to single gene disorders and congenital malformations were excluded, the death rate during the first year of life was similar in the two groups. The Pakistani children had an 18 times higher death rate from autosomal recessive disorders and a ten times higher death rate from malformations of the central nervous system. The difference in death rate between the two groups was probably due to the high rate of consanguinity among the Pakistani parents.

Cause of Death↗
PubMed1990

Turning data into dialogue.

Health visitors often see resource management as threatening, so changing their attitude is no easy task. But one training scheme did just that, as Joyce Steen and Marie Thistleton explain.

Communication↗
PubMed1989

[Hearing loss among children in Oslo].

The study concerns children born the years 1975-84. Only children in need of hearing aids are taken into account. The incidense was 1.08 per 1,000 live born children. The prevalens in January 1988 was 1.57 per 1,000 children, including 18 children moving into the city. The etiology among 75 children was 47% prenatal, 16% perinatal, 11% postnatal defects and further 26% of unknown neurogenic origin. Among the 63 impaired children living in Oslo 1988 15 or 24% had multiple handicaps. Identification of hearing loss before one year of age increased from 23% for children born 1975/79 to near 60% for children born 1980/84. At risk children should be tested before leaving hospital after delivery.

Adolescent↗
PubMed1988

Antacid in the prevention of upper gastrointestinal bleeding in burns.

In a retrospective survey the efficacy of a prophylactic antacid regime with aluminiumhydroxyde/magnesiumcarbonate (LINK, A.L. pharma) was investigated in 157 patients with major burns. Only 14% developed any sign of upper gastrointestinal stress ulceration, and only 5% revealed clinically significant bleeding indicating blood transfusion. No case developed haemodynamic instability, nor need for acute surgery, and no one died from haemorrhage. We found the regime economically attractive, and with few and reversible side effects. We conclude that our prophylactic regime is highly effective.

Adult↗
PubMed1983

Gastrin and gastrointestinal dyspepsia in pregnancy.

Fasting serum gastrin (SG) concentration and the SG response to a standard protein meal were investigated in 8 women with upper gastrointestinal dyspepsia in the 36th week of pregnancy and again 8 weeks after parturition, when the dyspepsia had disappeared. The fasting SG concentration was significantly higher (p less than 0.05) during pregnancy than post partum, whereas no statistically significant difference was found between the SG response to a protein meal stimulation during pregnancy vs. post partum. The demonstrated variations in gastrin secretion during and after pregnancy offer no explanation for the upper gastrointestinal dyspepsia of our patients.

Adult↗
PubMed1983

Variations in the release of the NH2-terminal fragment of gastrin-17 in the course of duodenal ulcer disease.

Fasting and meal-stimulated NH2-terminal gastrin concentrations in serum were significantly higher in patients with active duodenal ulcer than in control subjects and in patients with inactive duodenal ulcer (p less than 0.05). In contrast, the COOH-terminal gastrin concentrations (the bioactive gastrins) did not differ among the groups. Parallel variation in the NH2- and COOH-terminal gastrin concentrations occurred both during meal stimulation and as response to adrenaline or secretin infusion. In a longitudinal study of duodenal ulcer patients, higher NH2- than COOH-terminal gastrin concentrations were associated with the active phase of the disease, whereas this seldom occurred during the inactive phase (p less than 0.001). These data suggest that abnormally large amounts of the NH2-terminal fragment of gastrin-17 are released to the circulation during the active phase of duodenal ulcer.

Adolescent↗