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Biomedical subjects

J Stankiewicz

Publications and source records attributed to J Stankiewicz.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Electromyographic estimation of functional state of the mouth slit's muscles after the lip reconstruction by means of various methods].

The authors present the results of functional state examination of the orbicular muscle of the mouth in 28 patients operated by means of Abbe's and Karapandzicz's method because of vermilion border's carcinoma. It has been found that no features of neurogenic damage of the muscle were present in the group of patients operated by means of Karapandzicz's method and the return to its proper function was more frequent. It points out that Karapandzicz's method is less invasive in comparison with Abbe's method.

Electromyography↗
PubMed1985

Intubation-related tracheal stenosis in very-low-birth-weight infants. Diagnosis and treatment.

Five infants who developed intubation-related tracheal stenosis were treated surgically with an anterior cricoid split instead of a tracheostomy. This surgery allowed early extubation and discharge of these patients who, on follow-up, have had adequate phonation and no further respiratory compromise. We suggest that this surgery be considered for all infants who develop intubation-related tracheal stenosis.

Cricoid Cartilage↗
PubMed1984

Mucocutaneous lymph node syndrome.

A 3-year-old child presented with a short clinical history of fever and diffuse cervical lymphadenopathy, and the diagnosis of mucocutaneous lymph node syndrome was reached. We include a discussion of the case history and a brief review of this disorder.

Child, Preschool↗
PubMed1981

Studies on derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid. IV. Addition reactions of thioglycolic acid to 2-N-aralkylidene derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid.

In the course of studies on compounds with expected antiinflammatory and immunosuppressive activity a series of new derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid have been synthesized. Several new and unexpected details of the chemical properties of these compounds were revealed. The chemical structure of the new compounds was confirmed by degradation and identification of the decomposition products and by spectral analysis.

Amino Acids↗
PubMed1981

Studies on derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid. V. Syntheses of 2-N-aralkylidene and 2-N-aralkyl derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid.

A number of new N-aralkylidene and N-aralkyl derivatives of amides and hydrazides of 2-amino-4-p-chlorophenylthiazole-5-acetic acid (III-XXIX) have been synthesized. These compounds were obtained in two various ways depending on the character of substituents in the carboxyl group. The chemical structure of the newly obtained compounds was determined on the basis of the data of elementary and spectral analyses.

Amino Acids↗
PubMed1981

Studies on derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid. VI. Syntheses and properties of 2-N-aralkyl-alpha-sulphoderivatives of tert-amides of 2-amino-4-p-chlorophenylthiazole-5-acetic acid.

In the course of the studies on compounds with expected antiinflammatory and immunosuppressive activity several new tert-amides derivatives of 2-N-aralkylamino-alpha-sulpho-2-amino-4-p-chlorophenylthiazole-5-acetic acid were synthesized. Some of the previously described Schiff bases reacted with aqueous alcoholic solution of sodium bisulphite and as a result several (III-VIII) alpha-sulphoderivatives were obtained. The course of the reactions was studied and the structure of the new compounds was confirmed.

Amides↗
PubMed1979

Studies on the derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid. I. Syntheses and pharmacological analysis of acylderivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid.

A number of new acyl and imidoderivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid (II) and its methyl ester (VII) were synthesized. Methyl ester VII heated in benzene solution with acid anhydrides was transformed into adequate acyl derivatives (VIII, IX, X, XIII, XVI). Some of them (X, XIII, XVII) by heating with acetic anhydride underwent cyclization and were transformed into the imido derivatives (XI, XIV, XVIII). Compounds XI, XIV and XVI heated with diluted aqueous solution of sodium hydroxide underwent selective hydrolysis giving the respective dicarboxylic acids XII, XV, XVII. Pharmacological analysis revealed that some of the synthesized preparations exert an anti-inflammatory effect and allow to draw limited relations between chemical structure and pharmacological activity in this group of compounds.

Analgesia↗
PubMed1979

Studies on the derivatives of thiazole acetic acid. II. Syntheses and pharmacological analysis of 2-N-aralkylidene and 2-N-aralkyl derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid.

A number of 2-N-aralkylidene, 2-N-aralkyl and 2-N-aralkyl-alpha-sulphoderivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid (I, R = H) and its methyl ester (I, R = CH3) were synthesized. As a result of condensation of methyl ester I with various aromatic aldehydes in boiling benzene solution, the Schiff-bases (anils) II--VIII were obtained. After reduction with NaBH4 compounds II--VIII were transformed into adequate amino esters IX--XV. Esters IX--XV heated with diluted aqueous solution of sodium hydroxide underwent selective hydrolysis giving the respective amino acids XVI--XXII. Some of Schiff bases (II, III, V, VII, VIII) reacted with aqueous alcoholic solution of sodium bisulphite after its several (XXIII--XXVII). alpha-sulphoderivatives had been obtained. Several tests were performed in order to detect the anti-inflammatory and immunosuppressive activity of the compounds. The pharmacological analysis allowed us to draw conclusions concerning the relationship between chemical structure and biological activity in this group of compounds. The most efficacious immunosuppressive and anti-inflammatory activity exhibited 2-aralkyl-alpha-sulphoderivatives.

Adjuvants, Immunologic↗
PubMed1979

[2 cases of ocular myopathy].

On the basis of two cases of progressive external ophthalmoplegia the authors discuss the clinical manifestations of this disease and call attention to diagnostic difficulties.

Adult↗
PubMed1978

[Case of orthostatic arterial hypotension with neurologic manifestations (Shy-Drager syndrome)].

The authors report a case of idiopathic orthostatic arterial hypotension with neurological manifestations, rarely diagnosed in this country. The clinical manifestations corresponded to those of Shy-Drager syndrome, with an akinetic-hypertonic syndrome, pyramidal signs, sphincter disturbances, sexual potency loss and neurogenic muscle atrophy. Attention is called to the recent results of biochemical investigations of the blood in this syndrome, and among them to the blood level of noradrenaline which may be useful in the diagnosis.

Fecal Incontinence↗