Search PubMed⌕ Search

Biomedical subjects

J Staeffen

Publications and source records attributed to J Staeffen.

36 records · Page 2Linked to original sources
PubMedDate not supplied

A probable defect in the beta-oxidation of lipids in rats fed alcohol for 6 months.

Studies on fatty acid oxidation were made in rats fed for 6 months on a liquid diet containing 15% total calories as ethanol. After 6 months, a marked diminution was observed in the in vivo production of 14CO2 from labeled palmitate and octanoate in the ethanol-fed animals compared to their pair-fed isocaloric controls not receiving alcohol. Similar results were obtained in 14CO2 formation from 14C-fatty acids using liver mitochondria from these ethanol-fed rats after 6 months. The effect on octanoate beta-oxidation was larger than that for palmitate. Addition of purified acyl CoA dehydrogenase complexes and additional electron transfer flavoprotein complex to the mitochondria suggested that the ethanol-fed animals could have been deficient in the medium-chain acyl CoA-dehydrogenase complex.

Alcoholism↗
PubMedDate not supplied

[Hepatic coma].

Explore the source record for details and available documents.

Ammonia↗