Biomedical subjects

J Sroczyński

Publications and source records attributed to J Sroczyński.

At least 19 recordsLinked to original sources

PubMed1994

[C14-aminopyrine breath test and enzymatic liver tests in workers employed by the coke tar distillation department].

A group of 400 subjects divided into three sub-groups was examined. Group I consisted of 130 persons employed at the coke tar distillation department. Group II (controls) consisted of 70 persons also employed at the coke plant but free from occupational exposure. Group III was composed of 200 workers employed at the Building Factory. C14-aminopyrine breath test (ABT) was performed in 30 subjects randomly assigned from each group. A standard enzymatic liver test was assessed in all subjects examined. The range of tests performed did not permit to indicate the toxic effect of occupational environment on the liver tissue. Abnormal enzymatic liver test found in all groups could results, among others, from alcohol abuse among those tested. However, it was revealed that aromatic hydrocarbons to which workers of the coke tar distillation department were exposed to, stimulated the activity of the liver microsomal oxygenase assessed by ABT.

Adult↗

PubMed1994

[Frequency of chromosome aberration in workers of a coke derivative distillation plant].

The effect of occupational exposure on frequency of chromosomal aberrations in workers of coke by-product department was estimated. Fourty seven persons employed in that plant, exposed to tar substances, BaP and dust and 77 non-exposed controls were examined. Concentrations of tar substances, BaP and dust exceeded MAC 13.9, 10 and 1.5 times, respectively. The structural chromosomal aberrations were evaluated in peripheral blood lymphocytes after 72h cultivation, according to a modified Moorhead method. The findings did not revealed any significant differences in the frequency of chromosomal aberrations between the compared groups. These results seem to be produced by a relatively low level of exposure.

Adult↗

PubMed1993

[The ankle-arm index and whole blood viscosity in patients with type II diabetes mellitus with ischemia of the lower extremities].

The relationship was studied between the ankle-arm index (K/R) and whole blood and plasma viscosity in patients suffering from diabetes mellitus type II with ischemia of lower extremities. The measurements were carried out in 96 patients (80 males and 16 females), of whom 72 were in stage II of Fontaine progression. Immediately after determination of the K/R index blood was taken from vena mediana cubiti adding Na2EDTA for rheological test. Whole blood viscosity was measured with a Low-Shear 100 Contraves viscometer immediately after sampling, and plasma viscosity was measured with a capillary viscometer of Ubbvelohd within 2 hours after sampling. By the method of regression analysis and linear correlation it was found that increased whole blood and plasma viscosity significantly correlated with reduced K/R value in the patients. The obtained results are analysed in biophysical and clinical aspects.

Aged↗

PubMed1993

[Cytoenzymatic and ultramicroscopic investigations of blood in coke oven workers].

White blood cell count, cytoenzymology (acid and alkaline phosphatase, beta-glucuronidase and myeloperoxidase of granulocytes) and ultrastructure of granulocytes and NBT reduction test were performed in peripheral blood obtained from cokery plant workers. All the subjects were divided into groups according to degree of exposure to BaP. Occupational exposure to many factors during coke production, especially to high concentration of BaP cause perceptible changes of NBT reduction test in the group more exposed workers. A statistically significant of the totally activity of the acid phosphatase and beta-glucuronidase of granulocytes were found in this risk group. The changes in granulocyte function correlated with ultrastructural changes. The coking plant environment represent a strong stimulator of the neutrophil metabolism.

Adult↗

PubMed1993

[Certain complications of diabetes mellitus in old age].

The incidence rate of the diabetes mellitus in the aged patients has been analyzed. The clinical picture, complications, and the treatment varieties were evaluated in 2260 patients observed in the diabetes dispensary. Among them this disease has been diagnosed in 500 patients after 60 year of life. The results of the observations were compared with that found in 160 patients with diabetes diagnosed before the 35 year of life. This analysis revealed that the insulin treatment decreases in the aged patients the retinopathy rate, that in them the hypersensitivity and the resistance against this hormone are rather exceptional.

Aged↗

PubMed1993

[Pulmonary function changes as a late diabetic complications].

During diabetic process angiopathy of lung vessels may be expected. In the study authors evaluated values of spirometric and gasometric parameters in patients with diabetes mellitus in two groups--with and without diabetic complications. It was documented that diabetic process caused the decrease of pulmonary diffusion volume and some gasometric disturbances. This above mentioned spirometric and gasometric changes indicated some coexistence with a late diabetic complications.

Adult↗

PubMed1993

[Characterization of coke derivate distillation departments in coke plants. Hygienic and ergonomic conditions].

The studies were carried out in three coke plants mostly with the use of individual dosimetric methods but also with the stationary method. They revealed the values 2-5 times exceeding the MAC of the tar substances in the air of all workposts, and benzo(a)pyrene at several posts only. The other toxic substances like benzene homologous and benzologous and dust exceeded the MAC value only incidentally so that the workers of this department were less exposed than the people employed directly at the coke production. The ergonomic examinations did not reveal any excess of energetic expenditure or physiological cost. The results of medical studies will be presented in further papers.

Air Pollutants, Occupational↗

PubMed1993

[Effect of working in a coke plant on levels of carbon monoxide hemoglobin in employed workers].

Concentrations of carbon monoxide hemoglobin in blood of 48 furnace-room, and of 31 carbon derivatives department workers for many years exposed to carbon monoxide (divided into smokers and non-smokers) were assessed by spectrophotometry. CO levels were within the values provided in the corresponding standards for the occupational exposure, there was, however, the risk of periodically exceeding the MAC values. It has been found that HbCO levels in the workers of the furnace room and of the carbon derivatives department were much significantly higher than in the controls, both in the smoker and in the non-smoker group.

Carbon Monoxide↗

PubMed1992

[Different course of myocardial infarction in old age].

For the assessment of the peculiarities of acute myocardial infarction in patients aged over 60 years 100 patients with this disease treated at the Department of Internal and Occupational Diseases, Silesian Medical Academy were compared with 100 patients aged below 60 years. The location of myocardial infarction was similar in both groups. In the younger group premature ventricular beats were more frequent while in the older group supraventricular or ventricular tachycardia and left bundle branch block were more frequent. The death rate was much higher in the older group.

Age Factors↗

PubMed1992

[Endoscopic picture of hemorrhage from the upper digestive tract in elderly patients].

The causes of upper gastrointestinal tract bleeding were analysed in 412 patients dividing them into age groups below and over 60 years. Both groups were compared using endoscopic classification of bleedings by Forrest. In the group aged over 60 years a significantly higher per cent of type II lesion was found, especially non-bleeding vascular stump protruding from the bottom of the ulcer. This lesion was associated in nearly half the cases with recurrence of bleeding. The finding of this endoscopic picture should suggest the necessity of a more radical operation, although the operative risk is higher in patients aged over 60 years.

Age Factors↗

PubMed1992

[Evaluation of the immune system in workers engaged in the production of coal derivatives].

The study involved 361 people, 161 of whom were workers of coke plants and the remaining 200 constituted the control group. The coke plant workers were divided into the exposed and non-exposed groups. All of them were subject to the following tests: rosette test, determination of B lymphocytes, determination of the concentration of IgG, IgA, IgM immunoglobulins, and NBT granulocyte reduction test only were found in group I. Subgroups Ia, IIa, IIIa were established, in which subpopulations of T, TH-helper, TS-suppressor, TH and NK (Natural Killer) lymphocytes were discovered in group Ia. The above observations can probably be associated with exposure to tar substances which contain pyrenes.

Adult↗

PubMed1991

[Effect of working conditions in the coke-processing department on the secretory function of the adrenal cortex].

In 85 randomly chosen employees of the coal tar distillation department working at least 5 years, exposed to toxic substances not exceeding MAC except tar substances and benzo(a)pyrene, whose concentrations were high, blood level of cortisol and 17 OHCS and 17 KS excretion in urine were examined. In the most exposed group cortisol level decreased and the 17 OHCS excretion augmented.

17-Hydroxycorticosteroids↗

PubMed1991

[Effect of occupational exposure in coke production on various parameters of the hematopoietic system].

The basic parameters of the erythrocytes, white blood cell and coagulation were determined in 201 workers exposed occupationally to organic substances containing benzene and its homologues. Occupational exposure to many factors during coke production, especially to high concentrations of BaP, did not cause perceptible changes in the erythrocytes. Moreover, total number of the lymphocytes was increased in the peripheral blood of exposed workers. That maybe considered as a nonspecific exposure test for the influence of the aromatic hydrocarbons. In haemostasis system the thrombocytopenia and the abnormalities of the plasma coagulation factors were revealed.

Adult↗

PubMed1991

[Effect of simultaneous exposure to fluorine and manganese on health status of workers].

The effect of fluorine and manganese on the health of workers continually exposed to these elements was studied. The concentration of the chemicals did not significantly exceed maximum allowable concentrations only during three hours of work daily. Thirty-six workers directly exposed to fluorine and manganese were examined and compared with the controls. The authors demonstrated that exceeding permissible norms did not cause evident intoxication symptoms even though working in exposure had lasted for many years. However, some changes in the activity of liver indicatory enzymes may be one of the first symptoms of this organ's damage. Frequently occurring ++periodontosis and leukoplakia of the mucous membrane needed careful stomatological prophylaxis .

Adult↗

PubMed1991

[Evaluation of hepatic microsomal enzyme activity using C-l4-labeled aminopyrine breath test in patients with diabetes mellitus type 2 treated with tolbutamide].

Among 116 diabetic patients of the District Diabetic Polyclinic in Zabrze (51 type II treated with tolbutamide++, 36 type I treated with insulin, 29 type II treated with diet only) and 30 health persons functional microsomal hepatic fraction with ABT was assessed. Classical hepatic function test were done too. Among 49% patients under examination with type II diabetes treated with tolbutamide++ statistically significant decrease of value of ABT was observed as compared with other groups. Values of classical hepatic function tests in investigated patients were within normal values. Decrease in demethylation of aminopyrine shown as the abnormality in values of ABT can be considered as early symptom of hepatocyte damage caused by tolbutamide++. ABT is valuable method of appraising the liver's detoxication function in type II diabetes. Patients treated with tolbutamide++ should not receive any other drug known as inhibitor of microsomal enzymes of the liver.

Adult↗

PubMed1991

[Blood and plasma viscosity versus claudication distance in patients with obliterative atherosclerosis of the lower limbs].

The aim of the investigations was to show the influence of increased blood and plasma viscosity on the claudication distance in patients with obliterative atherosclerosis of lower limbs. The investigations were carried out in 53 patients: 41 men and 12 women (group I, age 45-67 years). The control group consisted of 100 healthy persons (group II) with similar range of age. The rheological studies of blood were carried out by low-shear 100 Contraves viscometer, the plasma viscosity--by means of capillary viscometer. Moreover, the total lipids, alpha, pre-beta, beta-lipoproteins, triglycerides, total cholesterol, free fatty acids, fibrinogen and hematocrit of the blood were determined. The blood for above mentioned estimations was collected before testing of the claudication distance. A significant increase of blood and plasma has been shown as well as an increase of total lipids, fibrinogen, triglycerides, total cholesterol, free fatty acids. The alpha lipoproteins were significant decreased in patients with intermittent claudication compared to the controls. The claudication distance ranged 10-500 m (the mean: 143 +/- 119 m). The correlation between claudication distance and blood and plasma viscosity was significantly negative (r = -0.42, p less than 0.001 and r = -0.32, p less than 0.05 respectively). The obtained results indicated that an increase of blood and plasma viscosity in patients with obliterative atherosclerosis of lower limbs was correlated to the decrease of claudication distance.

Aged↗

PubMed1990

[Blood and plasma viscosity and the distance of intermittent claudication in patients with type II diabetes and thrombophlebitis].

In 49 patients with insulin-resistant diabetes, with ischaemia of the lower extremities blood viscosity was measured at low coagulation rates and plasma viscosity was determined also. Moreover plasma measurements were done of total lipids, alpha-, pre-beta-, and beta lipoproteins, triglycerides, total cholesterol, free fatty acids, and, besides that, the hematocrit was measured. Immediately after blood sampling for rheological and biochemical investigations the distance of intermittent claudication was measured. A rather considerable increase of blood and plasma viscosity was noted in the patients in comparison with controls, other findings included disturbances of lipid metabolism, increased fibrinogen level, and a negative correlation between the distance of intermittent claudication and blood and plasma viscosity.

Aged↗

PubMed1990

[Effect of the work environment of the coke-processing industry on the respiratory system of coke factory workers].

The influence of the working environment in a coke factory on the respiratory system of workers was examined in 253 workers employed for at least 5 years at coke production in baking ovens, or at coke sorting and processing. They were exposed to high air concentrations of benzo(a)pyrene (BaP) and tar substances as well as other numerous toxic substances e.g. benzene++ derivatives, the level of which however, did not exceed the MAC values. Medical examination comprising the MRC questionnaire and spirometry , using Godart Expirograph, was carried out Among the exposed workers the non-specific chronic respiratory diseases with obstructive symptoms and chronic bronchitis were revealed more often than in the control group such factors as tobacco smoking and the duration of work also had their influence on the frequency of respiratory diseases. The possibility of the impact of high air concentrations of BaP and carbon monoxide cannot be excluded either.

Adult↗