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Biomedical subjects

J Spitz

Publications and source records attributed to J Spitz.

35 records · Page 2Linked to original sources

The use of an animal drawing test in the assessment and disposition of transsexualism.

Reported results of a study that compared two projective techniques for a group of 19 transsexuals who were seeking sex reassignment surgery. The Draw-A-Person Test (DAP), widely used in clinical settings, was contrasted to the Animal and Opposite Drawing Technique (AODT), which is a relatively new and little-examined variation of the DAP. Discussion focuses on the use of both measures as predictors of those transsexuals to be recommended for surgery. Use of the AODT as an effective measure in the assessment of transsexualism is investigated.

Adult

[The value of renal phlebography in the differential diagnosis of arteriographically hypo- or avascular lesions in the kidney (author's transl)].

The present paper is an investigation into the diagnostic value of renal phlebography for differentiating between arteriographically hypo- and avascular malignant lesions in the kidney and benign renal masses. In three examinations carried out on eight patients with renal masses, phlebography was of crucial diagnostic importance. In ten renal cysts a presumptive diagnosis made by arteriography was confirmed by phlebography. In another eight renal cysts, a case of haemorrhagic pyelitis and in two cases of unilateral pseudotumerous pyelonephritis, phlebography was of no value.

Adenocarcinoma

[Determination of serum digoxin. A comparison between RIA and EIA (author's transl)].

The results of two radioimmunoassays (RIA, precipitating technique), of a homogenous (EMIT) and a heterogenous (ELISA) enzyme immunoassay (EIA) for ascertaining the amounts of digoxin showed a good correlation in precision and a reasonably satisfying correlation in the recovery. However, there was a clear discrepancy in the amounts of digoxin concentrate in the serum of patients. Only the RIA of Abbott and the EIA of Boehringer showed no significant differences. Particularly noticeable was the tendency towards lower values in the EMIT-technique as well as its liability to unspecific serum changes (lipaemia etc.), which often made the detection of digoxin impossible. The routine use of this technique appears problematic. The need for establishing one's own laboratory and test-specific therapeutical range is pointed out.

Digoxin

[Fibrous cortical defects (author's transl)].

During a period of two and a half years, twelve fibrous cortical defects were discovered as incidental findings. With the exception of two cases, the radiological findings remained unchanged during the period of observation. One large defect extending into the diaphysis was submitted to surgery and verified histologically. The characteristic radiological appearances and the differential diagnosis from similar looking benign and malignant bone abnormalities are discussed and compared with the findings of other authors.

Adolescent

[The effect of iodine-containing radiographic contrast medium on TSH-TRH-tests (author's transl)].

In the course of an investigation of TRH-tests, 340 TSH-tests were performed in 120 patients before and after the administration of various iodine-containing radiographic contrast media in order to determine a possible effect on the TRH-tests. In addition, the peripheral thyroxin level and RIA-T3 content of the serum was determined. Mean TSH rise following TRH (delta-TSH) showed no significant difference before and after the contrast medium. Individual variations were, however, observed. In view of these results, it is concluded that the TRH-test provides reliable information after iodine exposure.

Contrast Media

[Thyroid hormones].

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Chemical Phenomena

Radioimmunoscintigraphy using monoclonal antibodies to CEA, CA 19-9 and CA 125.

131I labelled F (ab')2 fragments of monoclonal antibodies against CA 19-9 and CEA ("radioimmunococktail" IMACIS 1) were used in a prospective study (n = 60 patients) and in a retrospective study (n = 32 patients) for the detection of colorectal carcinomas (n = 67) and other gastrointestinal CEA/CA 19-9-producing tumors (n = 32). Sensitivity was 82% and specificity 90%. Immunoscintigraphy proved useful and complementary to CT scan and sonography, especially in the diagnosis of pelvic recurrences and intra-abdominal metastases. In addition, monoclonal antibody OC 125 (IMACIS 2) was used for the detection of ovarian carcinomas (n = 10) and other CA 125 producing tumors. Immunoscintigraphy was positive in all patients (n = 18) suggesting that this radioimmunological approach could be of use in the staging, therapeutic control and earlier diagnosis of recurrent epithelial ovarian carcinoma.

Antibodies, Monoclonal