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Biomedical subjects

J Spicer

Publications and source records attributed to J Spicer.

At least 37 records · Page 2Linked to original sources

A new measure of conversational experience: the speaking extent and comfort scale (SPEACS).

Few measures exist which directly assess aspects of conversational experience. We present and provide a psychometric assessment of the Speaking Extent and Comfort Scale (SPEACS), a new 20-item measure which assesses four aspects of past conversational experience: the extent and comfort of both general conversations and in conversations specifically about the self. All four SPEACS subscales exhibited good test-retest reliability. As predicted, the subscales related positively to social competence, disclosure, assertiveness, and perceived availability of someone to talk to, and negatively to social avoidance and social anxiety, providing support for their construct validity. Internal consistency data demonstrated that people tend to vary in how often and how comfortable they feel having conversations with different people. SPEACS offers a range of potential applications in areas with a focus on social networks, social experience and interaction, and the possibility of extension to other dimensions of conversational experience.

Adolescent↗

Development of a radiopharmaceutical information database.

OBJECTIVE: This article describes the development of a radiopharmaceutical (RP) computer database. Development and implementation of the database and services provided are presented. METHODS: A commercial database program was used to develop the structure for a radiopharmaceutical information database (RID) and to classify interaction information into several categories. The database is accessible to a variety of users through a network server. RESULTS: Information entered into the RID may be accessed easily and rapidly. The RID provides a wide spectrum of information services to its customers. CONCLUSION: The RID described is the first attempt to develop a database capable of entry and retrieval of RP information in an efficient and timely manner. The database is easy to use and maintain, and has virtually unlimited storage space on a network drive.

Database Management Systems↗

Treatment of patients with transitional-cell carcinoma of the urothelial tract with ifosfamide, paclitaxel, and cisplatin: a phase II trial.

PURPOSE: A phase II trial of ifosfamide, paclitaxel, and cisplatin (ITP) was conducted in previously untreated patients with advanced transitional-cell carcinoma (TCC) to assess its efficacy and toxicity. PATIENTS AND METHODS: Thirty patients with metastatic or unresectable TCC were treated with ifosfamide 1.5 g/m2/d for 3 days with paclitaxel 200 mg/m2 over 3 hours and cisplatin 70 mg/m2 on day 1 of each 28-day treatment cycle. Therapy was continued for a maximum of six cycles. Prophylactic hematopoietic growth factor (recombinant human granulocyte colony-stimulating factor [rhG-CSF]) was given on days 6 to 17 of each cycle. RESULTS: Twenty-three of 29 assessable patients (79%; 95% confidence interval [CI], 60% to 92%) demonstrated a major response (six complete [CR] and 17 partial [PR]) with response durations that ranged from 5 to 24+ months. Five patients with T4 bladder primary tumors had a major response, two with pathologic CR. At a median follow-up duration of 17.9 months, nine (31%) patients remain disease-free (range, 10+ to 24+). Hematologic toxicity included anemia, thrombocytopenia, and neutropenia; febrile neutropenia was observed in 17% of patients and 4% of cycles. No grade 4 nonhematologic toxicity was observed. Grade 3 nonhematologic toxicity included alopecia, allergy (3%), renal insufficiency (13%), and neuropathy (10%). Dose reductions or drug omissions were necessary for adverse events in seven (23%) patients. CONCLUSION: ITP is an active, well-tolerated regimen in previously untreated patients with TCC of the urothelial tract. Further study of this regimen in patients with both TCC and non-transitional-cell urothelial tumors is ongoing.

Adult↗

Long-term follow-up of patients with good-risk germ cell tumors treated with etoposide and cisplatin.

PURPOSE: To assess the durability of response and overall survival for patients with good-risk metastatic germ cell tumors (GCT) treated with four cycles of etoposide and cisplatin (EP). PATIENTS AND METHODS: Two hundred fourteen patients treated with EP on two consecutive randomized trials for good-risk metastatic GCT were the subject of this retrospective study. The response to therapy, relapse and survival status, and results of salvage therapy are reported. RESULTS: One hundred ninety-five patients (91%) achieved a complete response (CR). This included 182 patients (85%) who achieved a CR to chemotherapy alone and 13 patients (6%) who achieved a CR to chemotherapy plus surgical resection of viable GCT. Seventeen patients (9%) have relapsed from CR. The median time to relapse was 10 months, and the longest duration from treatment to relapse was 36 months in a patient who received three of four planned courses of therapy. Eight patients who either achieved an incomplete response (IR) or relapsed were rendered continuously disease-free by salvage therapy and are alive. One hundred eighty-three patients (86%) are alive at a median follow-up of 7.6 years. CONCLUSION: Four cycles of EP constitute effective therapy and can be offered to patients with good-risk GCT. In patients with intermediate- and poor-risk GCT, clinical trials remain a priority to identify more effective treatment.

Adolescent↗

Cynical hostility, anger, and resting blood pressure.

Research on associations of anger and hostility with resting blood pressure (BP) has generally ignored their interrelationships. The present study examined the individual and joint relationships of cynical hostility, anger-in, anger-out, and anger frequency with resting BP using the Cook-Medley Hostility Scale and the Spielberger anger scales. Multiple regressions were conducted on data from a community sample of 105 men and women to examine the main and interactive effects of anger and hostility on BP, controlling for established physical covariates. Diastolic BP was inversely related to anger-in scores in men and women. Systolic and diastolic BP were positively associated with Ho (hostility) score only in women. No confounding or interactive effects of hostility and anger on BP were found. It is suggested that the sex-specific link between cynical hostility and BP may reflect a chronic mismatch between the social cognitions of cynically hostile women and some of the cultural norms that govern women's social lives.

Adult↗

Categorisation of the patient's medical condition--an analysis of nursing judgement.

This paper is a report of a study designed to explore the way in which community and hospital based nurses categorised 35 medical conditions. The results, obtained from a series of card-sorts using a Multiple Sorting Task and a modified Q-Sort, found that nurses used four global sub-categories of severity to categorise them. The findings provided a basis for an analysis of nursing assessment and established that they were realised as prognostic judgements. Discussion of the structure of the categories led to a possibility that the cognitive skill referred to as 'intuition' could be explained by the way in which clinical knowledge comes to be organised in memory.

Adult↗

Criteria for breast reconstruction surgery: another viewpoint.

A more articulated model than now exists for shaping criteria for breast reconstructive surgery can be drawn from an examination of the criteria followed by museums for treating work of art. This article characterizes the challenge for oncologists and general surgeons to convey usable information to women facing a mastectomy and propose a model for making these decisions on the basis of an art museum curator's assessment of the appropriate degree of restoration for a range of damaged works of art.

Art↗

Self management practices in adult asthmatics.

AIM: To examine how adherence to medications and use of competencies (eg, avoiding personal precipitants and managing an acute attack) vary by age, sex, education and number of symptoms in a sample of adult asthmatics. METHODS: 412 adult asthmatics, members of two asthma societies, participated in a mailed survey. The questionnaire contained measures of asthma medication adherence, asthma health competencies, asthma symptoms, and demographic characteristics. RESULTS: Older asthmatics were more likely to adhere and to use more competencies. Females used more competencies than males. Asthmatics with higher numbers of symptoms used more competencies. No differences were found by educational level. CONCLUSIONS: Better adherence in older asthmatics may be due to their having developed greater recognition of the efficacy of medications. The more extensive use of competencies by older people and by women reflects previous findings that these groups value health more and engage in less health threatening behaviours in general. The results also suggest that experiencing asthma symptoms motivates better self management practices. The study raises awareness of the role of competencies in controlling asthma, and should assist health professionals to identify specific differences in self management.

Adult↗

Successful substitution of rectal metronidazole administration for intravenous use.

Wound infection and isolation of anaerobic organisms before and after intravenous and rectal administration of metronidazole were studied in 24 505 surgical patients. In the 6303 patients who underwent "risk" surgery (bowel, biliary, gynaecological, or otolaryngological surgery) introduction of intravenous metronidazole was associated with a striking fall in wound infection and wound anaerobe isolation rates; and the changes were maintained when the majority of metronidazole used was in suppository form. In the 18 202 patients who underwent "clean" surgery (e.g., orthopaedic, ophthalmic, and plastic surgery) metronidazole use was associated with a small formulation-independent change in infection rate without change in anaerobe isolation rates. Without compromising clinical care the use of intravenous metronidazole can be limited to a minority of patients with special needs.

Anaerobiosis↗