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Biomedical subjects

J Sperling

Publications and source records attributed to J Sperling.

62 records · Page 4Linked to original sources
PubMed1976

[The influence on heart conduction time and refractory period of in vitro and in vivo prostaglandins].

The effects of PGE1, PGE2 and PGF2alpha on conduction time and functional refractory period in the isolated rabbit atrium and in the cat heart in vivo were investigated. In the isolated rabbit atrium the PGs (10(-8)--10(-5) g/ml) were without any effect in this respect. In contrast there was a dose-dependent decrease of conduction time and prolongation of functional refractory period in the cat heart in vivo following PG-infusions (2,0--8,0 mug/kg/min i.v. over a period of 5 min). These findings indicate the absence of a direct quinidine-like membrane action of PGs in the heart. The indirect, depressive effects of PGs on conduction time and functional refractory period in the heart in vivo, should be considered responsible for the antiarrhythmic action of PGs.

Ajmaline↗
PubMedDate not supplied

Geographic information systems (GIS): new perspectives in understanding human health and environmental relationships.

Geographic information systems (GIS) and digital computer technology will advance the mission of the Centers for Disease Control and Prevention (CDC) and Agency for Toxic Substances and Disease Registry (ATSDR) to protect public health. Geographic positioning, topology, and planar and surface measurements are basic GIS properties which enable highly precise locational referencing of spatial phenomena. The growing uses of remotely sensed imagery and satellite facilitated global positioning systems are contributing to unprecedented surveillance of the environment and greater understanding of known and suspected environmental disease associations with human and animal health. Earth science and public health monitoring GIS databases offer new analytic opportunities for disease assessment and prevention.

CD-ROM↗
PubMedDate not supplied

Juvenile dermatomyositis: serial studies of circulating autoantibodies to a 56kD nuclear protein.

In this study we report that circulating antibodies recognising a 56kD protein, which is a component of large nuclear ribonuclear particles, are commonly found in children with juvenile onset dermatomyositis (JDM). These autoantibodies, as detected by Western blotting, were present in over 90% (24/26) of sera from JDM patients, which exceeds the number of patients with adult onset myositis who express this antibody (up to 85%). In addition, they were not found in healthy controls. Serial bleeds taken during the course of the disease in eleven children with JDM enabled us to follow the titre of anti-56kD autoantibodies. Sera were also tested by indirect immunofluorescence for anti-nuclear antibodies (ANA) using Hep2 cells as substrate. These studies revealed two distinct patient groups: Group 1 with anti-56kD antibody positive and ANA positive; and Group 2 with anti-56kD antibody positive and ANA negative. In Group 1 there was some correlation between disease activity and anti-56kD levels which was absent among patients in Group 2.

Antibodies, Antinuclear↗