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Biomedical subjects

J Spain

Publications and source records attributed to J Spain.

9 recordsLinked to original sources
PubMed2001

Lipid-lowering efficacy, safety, and costs of a large-scale therapeutic statin formulary conversion program.

STUDY OBJECTIVE: To assess the lipid-lowering efficacy, safety, and costs of a large-scale statin formulary conversion program. DESIGN: Prospective, observational study. SETTING: Tertiary academic medical center. PATIENTS: A total of 980 patients consented to participate; 942 patients completed the study. INTERVENTION: Patients were converted from their current statin therapy to either cerivastatin 0.4 or 0.8 mg/day, or simvastatin 80 mg/day, using a conversion algorithm. MEASUREMENTS AND MAIN RESULTS: Efficacy and safety were evaluated at baseline and after 6 weeks of therapy; costs were also measured. Overall attainment of the National Cholesterol Education Program (NCEP) goal for low-density lipoprotein cholesterol (LDL) increased from 64.8% to 74.5% of patients (p<0.001); mean LDL decreased from 115+/-30 mg/dl to 106+/-25 mg/dl (p<0.001). Adverse events occurred in 3% of patients, and included myositis (0.6%) and increased hepatic transaminases (0.1%). Overall costs were reduced by $115/patient treatment-year. CONCLUSION: Statin therapeutic interchange can improve lipid control at reduced costs. The possibility of uncommon but potentially serious adverse effects suggests that these programs require appropriate monitoring.

Aged↗
PubMed1999

Preparation of 2-aminomuconate from 2-aminophenol by coupled enzymatic dioxygenation and dehydrogenation reactions.

2-Aminomuconate is an intermediate in the oxidative metabolism of tryptophan in mammals. The compound is not commercially available, and studies of its metabolism have been prevented by the lack of a chemical synthesis and the instability of the molecule. We report here the formation of 2-aminomuconate from 2-aminophenol by the coupled action of 2-aminophenol 1,6-dioxygenase and 2-aminomuconic semialdehyde dehydrogenase from Pseudomonas pseudoalcaligenes JS45, and isolation of the product by anion exchange chromatography. The overall procedure was completed within 3 h with a yield of 62%. The availability of the dicarboxyl alpha-amino acid provides the basis for investigation of the physiological function of 2-aminomuconate in the neuropathologically significant oxidative metabolism of tryptophan.

Journal Article↗
PubMed1999

Pharmaceutical logistics in the European theater.

This article describes the responsibilities and objectives of the pharmacy officer for the U.S. Army Medical Materiel Center, Europe. Pharmacists' experiences and knowledge offer advantages in the ordering, storage, and distribution of medical materiel. Exploitation of new technology and a customer-focused attitude encourage a working environment that capitalizes on pharmaceutical expertise. The use of temperature monitors, enhanced automation opportunities, expired drug return credits, and other customer-focused initiatives exemplify pharmacists' value to military medical logistics organizations. An overview of the pharmaceutical pipeline to U.S. military and State Department customers in the European theater is provided.

Clinical Competence↗
PubMed1994

Pharmacy operations in the second infantry division.

A forward-deployed infantry division offers many challenges to its medical elements. These elements work in a peacetime environment providing quality medical care while preparing and training for a wartime mission to conserve the fighting strength. Pharmacy operations play significant roles in the accomplishment of both missions. The roles of the Division Pharmacist and the provision of pharmacy services in the Second Infantry Division are discussed.

Allied Health Personnel↗
PubMed1993

Challenges facing pharmacy practice during Operation Desert Storm.

Many challenges face the pharmacist in a combat zone hospital. The 13th Evacuation Hospital, Wisconsin Army National Guard was deployed in support of Operation Desert Storm. Its mission before and during the ground campaign identified key areas where pharmacy involvement assisted in the provision of care. Special skills and subject areas were determined. This article reviews the authors' experiences and offers suggestions to aid pharmacy personnel in preparation for future deployment.

Anti-Bacterial Agents↗
PubMed1985

Prehabilitation.

The rehabilitation of an athletic injury may represent the greatest challenge of an athlete's career. The challenge to the sports medicine professional is to provide the most up to date and best care possible. Prehabilitation is one part of that care. Management of the acute injury, conditioning the athlete, and preventing unnecessary atrophy are all steps in helping the athlete to meet his or her challenge.

Athletic Injuries↗
PubMed1984

Filariasis in Colombia: prevalence of Mansonella ozzardi in the Departamento de Meta, Intendencia del Casanare, and Comisaría del Vichada.

The prevalence and distribution of filarial infections among the inhabitants of adjacent regions of the Departamento del Meta, Intendencia del Casanare, and Comisaría del Vichada in northeastern Colombia was determined by collection and examination of blood samples using the Knott's method. Mansonella ozzardi, the only species detected, was found in 2.5% of the samples collected in Meta (6/243), in 4.9% from Casanare (12/247) and in 2.5% from Vichada (3/137). All of the microfilaria carriers were Indians who had migrated from other parts of eastern Colombia, principally from the interior of Meta and Vichada. These results indicate that filariases are not endemic in the regions examined, and suggest that influx of microfilaria carriers with sufficiently high microfilaremia could establish new foci of transmission in areas where appropriate vectors are abundant.

Colombia↗