Search PubMed⌕ Search

Biomedical subjects

J Spahr

Publications and source records attributed to J Spahr.

18 recordsLinked to original sources
PubMed1981

Renin producing Wilms' tumor.

A 4-yr-old boy with Wilms' tumor, hypertension, and hyperreninemia is presented. Three times as much renin was extracted from tumor tissue as from adjacent renal parenchyma, suggesting that the tumor itself was the primary source of the renin and cause of the hypertension. Other reported cases of hypertension and increased renin production with Wilms' tumor are reviewed. Hypertension is a very frequent finding in patients presenting with Wilms' tumor. The possibility that many of these neoplasms may be found to hypersecrete renin if properly investigated is discussed.

Child, Preschool↗
PubMed1980

Experience with Gleason's histopathologic grading in prostatic cancer.

The inaccuracy of clinical staging as a predictor of the biologic potential of prostatic cancer has prompted evaluation of additional methods of assessment. We reviewed 228 patients with prostatic adenocarcinoma who presented during a 4-year period. Of the 228 patients 144 with no detectable bony disease underwent staging pelvic lymphadenectomy with or without preliminary bilateral pedal lymphangiography. Histopathologic specimens of the primary diagnostic prostatic biopsy were classified with Gleason's grading system of tumor differentiation. Of the patients with Gleason's sum of 8, 9 or 10, 93 per cent had regional nodal metastases, regardless of preliminary clinical stage. Furthermore, no patient with Gleason's sum of 2, 3 or 4 had nodal metastatic disease. The incidences of falsely positive and falsely negative lymphangiograms were 29 and 35 per cent, respectively, reflecting the unreliability of pedal lymphangiography to predict nodal involvement accurately in patients with prostatic cancer. The Gleason system of histopathologic grading was reliable and reproducible, and afforded an accurate prediction of the surgical stage of disease.

Adenocarcinoma↗
PubMed1978

[Practical experiences with the Octopus automatic perimeter (author's transl)].

A statistical analysis comparing the results of more than 1000 visual field examinations carried out with the automatic perimeter Octopus and with a conventional Goldman-perimeter, clearly demonstrates the superiority of the automatic instrument in many respects: Apart from a higher precision of the perimetric measurements (smaller fluctuations), a better reproducibility of the results (larger correlation coefficients) is noticed. Due to great ease of operation of the automatic perimeter, the ophthalmologist is discharged from the time-consuming task of perimetric examinations.

Computers↗
PubMed1978

[Proteinuria].

Explore the source record for details and available documents.

Child↗
PubMed1977

IgE myeloma with osteoblastic lesions.

A 69-yr-old man with persistent anemia had multiple myeloma with an IgE-type kappa M component and Bence Jones proteinuria. Bone x-rays revealed occasional lytic lesions associated with a diffuse sclerotic reaction throughout the skeleton. Special bone histologic studies utilizing tetracycline labeling, undercalcified sections, and microradiography confirmed active osteoblastic activity. This case was compared with the four previously reported cases of IgE myeloma, one of which also had osteosclerosis.

Aged↗
PubMed1976

Static perimetry: strategies.

In static perimetry the method of limits is widely used for threshold determinations. Its performance is compared with that of a certain modification of the staircase method (repetitive up and down) by means of simulations, where the behaviour of the observer is described by an assumed psychometric function. Systematic and random errors are considerably smaller with the up and down method. Further consideration is given to signal detection theory and to the concept of optimal strategy.

Humans↗
PubMed1976

Static perimetry: accuracy and fluctuations.

Threshold fluctuations are divided into short-term and long-term effects applying statistical methods. Sixteen normal and pathological visual fields were analysed in order to obtain values for the short-term, long-term and total fluctuations. Special attention is paid to fortuitous variations between the results obtained at successive examinations. Finally the concept of spatial correlations is introduced.

Humans↗
PubMed1976

[Advances in the automation of perimetry (author's transl)].

The most important improvements and innovations since 1973 in the automatic perimeter Octopus are described. On the one hand, they include instrumental modifications, namely spatial separation of the perimeter from its control panel, the introduction of step motors in order to increase the accuracy of setting of the stimulus coordinates, the tilting of the perimeter cupola and patient in order to increase stability and comfort of the latter, a fully automated fixation control system, the use of a magnetic-tape recording system, providing analytical programs for the computer and recording computer-answers at the same time. On the other hand, progress has been made in the optimisation of threshold determination methods in the visual field and in the design of methods for the graphical display of the sensitivity distribution across the visual field.

Data Display↗
PubMedDate not supplied

Some aspects of the automation of perimetry.

Manual perimetry has certain inherent limitations stemming from both the patient and the examiner. Automated perimetry, if properly developed, can offer the advantages of exact reproducibility of the examination strategy, accuracy achieved through averaging of repeated determinations, and systematic application of previous data to the current examination. The history, concepts and clinical practically of automated perimetry are discussed. Several systems capable of performing functions resembling human intellectual activity are commerically available; one, the OctopusTM, is described in detail.

Data Display↗
PubMedDate not supplied

Cytopathologic findings in pulmonary blastoma.

The exfoliative cytologic description of a pulmonary blastoma is reported. The debated histogenesis of these tumors is briefly reviewed. A review of all case reports recording cytopathology findings indicates that these rare tumors yield diagnostic cells in only a minority of cases. In the present case, as in previous reports, only the epithelial component (carcinoma) was recognized prior to the histopathologic diagnosis. The stromal cells were less numerous and not as conspicuous as the epithelial cells. The diagnosis of pulmonary blastoma should be considered whenever nonsquamous carcinomatous cells plus a separate population of smaller malignant cells are seen in a pulmonary cytology specimen.

Carcinoma↗
PubMedDate not supplied

Preleukemic granulocytic sarcoma of cervix and vagina: initial manifestation by cytology.

Granulocytic sarcoma is an unusual form of tumefaction caused by acute granulocytic leukemia. On rare occasions, the lesion precedes the leukemic phase and presents as a mass with a normal peripheral white cell count. This report describes the initial manifestation of granulocytic sarcoma by vaginal cytology in a 39-year-old female with Down's syndrome. Six days after admission, the patient died of acute peritonitis following spontaneous perforation of the bowel. Autopsy revealed involvement of cervix, vagina, bowel wall and one pelvic lymph node by granulocytic sarcoma. Bone marrow examination confirmed the preleukemic stage of the disease. Cytologically, the malignant cells occurred singly. No nucleoli were seen. The differential diagnosis between malignant lymphoma and granulocytic sarcoma rests upon a positive naphtol AS-D chloroacetate esterase stain in granulocytic sarcoma. This stain may be performed on paraffin-embedded sections or on smears.

Adult↗
PubMedDate not supplied

Pulmonary cytopathology of an invasive thymoma.

The cytopathology of an invasive thymoma that penetrated the bronchus is presented. As is typical of these neoplasms histologically, both epithelial cells (thymocytes) and lymphocytes were seen cytologically. However, the benign appearance of the thymocytes precluded a neoplastic diagnosis initially. Only with the knowledge that an anterior mediastinal mass is present roentgenographically can this diagnosis be safely made cytologically.

Bronchial Neoplasms↗