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Biomedical subjects

J Soto

Publications and source records attributed to J Soto.

At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

Low radon doses sensitize MCF-7 human breast cancer cells to taxol.

We studied whether human breast cancer cells show increased sensitivity to the chemotherapeutic agent taxol when they have been treated with low radiation doses (1.7-3.2 x 10(-3) Gy) from the gas radon. To this end, MCF-7 cells were cultivated in a medium either with or without dissolved radon for 3 days and then exposed to taxol (50 nM). Cells exposed to low doses of radon and then to a concentration of 50 nM of taxol exhibit a lower proliferation rate and a lower viability than cells treated with the same concentration of taxol but not irradiated. These findings indicate an important interaction of radon and taxol in the inhibition of MCF-7 cell growth.

Antineoplastic Agents, Phytogenic↗
PubMedDate not supplied

Needle sharing behaviour among injection drug users (IDUs) in treatment in Montreal and Toronto, 1988-1989.

Injection drug users (IDUs) entering treatment programs in Montreal and Toronto were recruited for a study of drug using behaviour and risk of HIV infection. Only those who had injected within 6 months of entering their treatment program were eligible for participation. 183 subjects were recruited in Montreal and 167 in Toronto between November, 1988 and October, 1989. Each participant completed a standardized interviewer-administered questionnaire which focussed on, among other things, drug history and needle sharing behaviour. Approximately three-quarters of respondents in both cities reported sharing needles and syringes within the 6-month period prior to their entry into treatment. Our analysis, which focussed on variables associated with needle sharing revealed that having a sexual partner who injected, trouble obtaining sterile needles and syringes and cocaine injection were significantly and independently associated with needle sharing in a logistic regression model which also controlled for city of recruitment.

AIDS Serodiagnosis↗
PubMedDate not supplied

[Rn 222 levels at the "Las Caldas de Besaya" spa in Cantabria].

222Rn levels in the water and air of the Las Caldas de Besaya spa have been analysed during a year period. The measured values are high in the indoor air of the spa with maximum concentrations of 10(4)Bq/m3. The dose equivalent for patients and workers resulting to exposure of these radon levels were calculated and compared with the derived from the mean natural radiation.

Balneology↗
PubMedDate not supplied

[Tetanus in adults: mortality. Study in 130 cases].

Out of the 557 cases of tetanus in adult patients seen in our institution over 61 years, we have selected for analysis the 130 patients who where admitted to our service since its creation in 1968. We have found a trend toward older patient age in recent years. The age distribution showed a bimodal curve which was maintained in the different periods and was due, in the last one to the population of parenteral drug abusers. In the last 20 years there has been an increase in severe forms (p less than 0.001). The mortality was statistically associated with clinical severity (p less than 0.001) and with the surgical portal of entry (p less than 0.05). The development of intensive care reduced the mortality rate from 58.3% in the period before ICU to 24.6% in the 130 patients cared for since the service was created (p less than 0.001). In the last 10 years, the mortality rate of 41 patients was 9.7%. The most common cause of death was cardiac arrest (68.7%). Superinfection was the second cause (25%). The use of beta-blockers in patients with severe tetanus, with significant autonomic abnormalities, reduced the mortality from 72.7% to 14.8% (p less than 0.001). The mortality of superinfection has been maintained, without statistically significant changes.

Adolescent↗
PubMedDate not supplied

Contact dermatitis by sensitization to amine-type antioxidants.

Numerous reports had been published implicating IPPD and other amine-type antioxidants as the causative agents in patients with allergic sensitization following the use of industrial and household products that have black rubber in their composition. The amine-type antioxidants, used to stabilize the polymer chains and to prevent rubber from cracking, are the agents more frequently implicated in this type of contact allergic dermatitis. Based on a case of a patient who had erythematous edematous and vesiculous processes in the periocular region that appeared a few hours after the use of a video camera with a black rubber eyepiece, we reviewed the clinical features, and the etiological agents of this infrequent form of contact dermatitis. This patient represents the first described case in the literature of allergic sensitivity after the use of a video camera eyepiece.

Adult↗
PubMedDate not supplied

Assessment of the time course of drugs with inhibitory effects on hepatic metabolic activity using successive salivary caffeine tests.

In clinical practice is very important to know the time course of the inhibitory effects of drugs to avoid side effects when several agents are taken concomitantly. We attempted to validate the effectiveness of successive salivary caffeine tests establishing the time for cimetidine to inhibit hepatic metabolism. The time of cimetidine's inhibitory effect as reported in other studies was chosen as the reference. In this open-label, prospective longitudinal, 16-day study, five healthy volunteers were treated with cimetidine 1 g/day for 5 days. After the intake of caffeine 300 mg, salivary caffeine tests were carried out on days -1 (control value), 1, 4, 8, 12, and 16. The mean systemic caffeine clearance was decreased after 24 hours of cimetidine. The drug's maximum inhibitory effect was reached after 5 days of administration, returning to previous values progressively 1-7 days after discontinuing cimetidine. No change occurred in the apparent volume of distribution. The time course of cimetidine's inhibitory effect was similar to that described with other methodologies. Although this was a pilot trial and the results have to be confirmed, it seems that successive salivary caffeine measurements could be a safe, reliable, noninvasive test for exploring the time course of the inhibitory effects of drugs on hepatic metabolism.

Adult↗