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Biomedical subjects

J Sondergaard

Publications and source records attributed to J Sondergaard.

At least 37 records · Page 2Linked to original sources

Recovery of prostaglandins in human cutaneous inflammation.

An in-vivo skin perfusion technique has been used to study the pharmacological activity in inflamed skin of patients with allergic contact eczema. Perfusates from 35 out of 45 patients contained a smooth-muscle-contracting agent with prostaglandin-like properties. Solvent partition followed by thinlayer chromatography revealed this activity to be due to a mixture of prostaglandins E and F. This direct evidence supports the view that prostaglandins mediate inflammation in man.

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