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Biomedical subjects

J Sola

Publications and source records attributed to J Sola.

At least 73 records · Page 4Linked to original sources
PubMed1991

Liver changes in patients with hyperthyroidism.

We studied liver changes in the hepatic biopsies of five patients with hyperthyroidism. A characteristic histopathologic picture consisting of mild to moderate intrahepatocytic cholestasis, lobular inflammatory infiltrate with some eosinophils, and Kupffer cell hyperplasia was found in all cases. We discuss the specificity, clinicopathological correlations and the possible pathophysiology of these lesions.

Biopsy↗
PubMed1991

Lymphoma of the gastric stump: report of a case.

We report a case of primary lymphoma on a previously resected stomach in a 62-year-old man. The patient was treated 22 years earlier with a partial gastrectomy and Billroth II reconstruction for a benign gastric ulcer. The rarity of this entity and its possible relationship with pseudolymphoma or lymphoid nodular hyperplasia is discussed, and the literature is reviewed.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1989

Nonhuman cells correctly sort and process the human lysosomal enzyme cathepsin D.

Cathepsin D, like most lysosomal enzymes, undergoes multiple proteolytic cleavages during its lifetime. Although the significance of the earliest cleavages of cathepsin D is apparent (loss of the NH2-terminal signal peptide and activation peptide), functions of the two later cleavages are not understood and do not occur in all species. To examine these later events, a cDNA coding for human cathepsin D, which is normally processed to a two-chain form, was isolated and then expressed in mammalian cells from species which do not process the enzyme to the two-chain form. Analysis of the expressed human cathepsin D demonstrated proteolytic processing identical with that seen in normal human fibroblasts. Since processing to the two-chain form of the enzyme occurs in the lysosome, these studies revealed that the human cathepsin D was correctly sorted. The data also indicated that the sorting mechanism was conserved between diverse species and that late proteolytic processing in a variety of species was not determined by the presence or absence of the processing enzymes in the cell.

Amino Acid Sequence↗
PubMed1989

[Kinetics of eicosanoid formation in human epidermal cells in suspension].

Increased levels of eicosanoids in lesions of psoriasis suggest activation of arachidonic acid metabolism in different cell types play a physiopathologic role. The contribution of each cell type present in psoriasis has been the subject of some controversy, which has led us to study the metabolism of arachidonic acid in human epidermal cells suspensions. 12-HETE was found to be the main product, followed by PGE2 and PGF2 alpha; no 5-lypoxygenase products were found. Thus epidermal cell contribution to LTB4 levels present in plaques of psoriasis appears to be irrelevant. Conversely, increased levels of 12-HETE probably do result from arachidonic acid metabolism by epidermal cells.

Arachidonic Acids↗
PubMed1988

Expression of outer membrane protein II by gonococci in experimental gonorrhea.

Gonorrheal urethritis was induced in three males by intraurethral instillation of predominantly pilus+ protein II- gonococci. Virtually all gonococci reisolated from the infected men exhibited protein II+ phenotype. The reisolated gonococci expressed five distinct outer membrane protein II species. Protein IIc+ organisms predominated in urines of all three subjects, but variants expressing this particular protein II were rarely spawned in vitro by input organisms. Protein IIc+ gonococci appeared early in one man's infection; they were joined later by variants that displayed eight other protein II phenotypes, including protein II-. These results show that input protein II- gonococci are supplanted by protein IIc+ variants during incipient gonorrheal urethritis. As infection progresses, a broader variety of protein II+ variants appears.

Bacterial Outer Membrane Proteins↗
PubMed1986

Subarachnoid hemorrhage in the presence of a cerebral arteriovenous malformation and an intraventricular oligodendroglioma: case report.

The authors report a case of a ventricular oligodendroglioma associated with a cortical arteriovenous malformation. The patient presented with subarachnoid hemorrhage. Computed tomographic scan showed an intraventricular hyperdense lesion, mimicking a hematoma. Angiography revealed a superficial arteriovenous malformation in the right parietal lobe, unrelated to ventricular cavities. Both lesions were treated during the same operation. The diagnostic difficulties and the significance of this uncommon association are discussed.

Adult↗
PubMed1985

Intracranial tumor biopsy--CT-guided stereotactic surgery.

A modification of Gildenberg's technique for brain tumor biopsy is described. Marking the light beam of the gantry on the scalp with a pencil, when the lesion appears on the screen, no ScoutView is necessary. With radiopaque marks on the drawn lines, the levels of the slice are transferred to a lateral conventional X-ray, for calculation of the 'Z' coordinate. 'X' and 'Y' coordinates are determined on the CT scanner.

Adolescent↗
PubMed1984

The properties of the interaction between bovine pancreatic ribonuclease a and mononucleotides supports the existence of several binding sub-sites in the enzyme.

The binding of 5'AMP, 5'GMP, 5'CMP, 3'CMP and Cl6RMP to RNAase A was studied by means of the gel filtration technique. It was found that only one molecule of 3'CMP binds strongly to the enzyme although a very unspecific binding is also present. The interaction of 5'AMP and 5'GMP with the enzyme shows one strong binding site and several weak binding sites, whereas two molecules of 5'CMP bind to RNAase A with equal strength. Cl6RMP shows an anomalous behaviour as both split peaks and troughs are found in the chromatogram. The Ka values for 3'CMP and the strong binding site of 5'AMP and 5'GMP are very similar whereas that for the two binding sites of 5'CMP is smaller (about 2.2 X 10(-4)M-1 and 0.5 X 10(-4)M-1, respectively at pH 5.5, I = 0.01 and 25 degrees C). The results are in general agreement with the known multiplicity of ligand-binding subsites in RNAase A.

Animals↗
PubMed1983

Epidermoid cyst occurring within a lumbosacral myelomeningocele. Case report.

The authors report the case of an infant who presented with an epidermoid tumor contained in a lumbosacral myelomeningocele. The association of spina bifida aperta and congenital intraspinal tumors is rare. Only two cases of teratoma and two cases of epidermoid tumors arising within a meningocele have been documented previously.

Epidermal Cyst↗
PubMedDate not supplied

Percutaneous transhepatic stenting by Wallstents of portal vein and bile duct stenoses caused by immunoblastic sarcoma in a liver transplantation.

Posttransplant lymphoproliferative disorders are infrequent tumors related to chronic immunosuppressive therapy. We present a liver transplant recipient who developed such a tumor in the porta hepatis that provoked obstruction of the entire portal triad. Treatment consisted of systemic chemotherapy, percutaneous dilatation, and placement of Wallstent endoprostheses across both biliary and portal vein stenoses. The patient died 3 weeks later of pneumonia and sepsis. At necropsy, the tumor was completely necrosed and the prostheses in both the common bile duct and the portal vein were patent.

Cholestasis↗