Biomedical subjects

J Sokolow

Publications and source records attributed to J Sokolow.

13 recordsLinked to original sources

PubMed1996

Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia.

The TLE genes are the human homologues of Drosophila groucho, a member of the Notch signaling pathway. This pathway controls a number of different cell-fate choices in invertebrates and vertebrates. We are interested in investigating the functions of the TLE gene family during epithelial determination and carcinogenesis. We show that expression of individual TLE genes correlates with immature epithelial cells that are progressing toward their terminally differentiated state, suggesting a role during epithelial differentiation. In both normal tissues and conditions resulting from incorrect or incomplete maturation events, such as metaplastic and neoplastic transformations, TLE expression is elevated and coincides with Notch expression, implicating these molecules in the maintenance of the undifferentiated state in epithelial cells. We also show that TLE1 and TLE2 are organized in a tandem array at chromosomal location 19p13.3, while TLE3 maps to 15q22.

Animals↗

PubMed1983

Computed tomography of pressure sores.

Twenty-three paralyzed patients admitted for treatment of recurrent pressure sores were evaluated by computed tomography, bone scanning, gallium scanning, and sonography. Computed tomography was helpful in detecting associated peripelvic and pelvic abscesses and pelvic osteomyelitis, which were undiagnosed by all other modalities combined in more than half of the patients. Computed tomography was also useful in preoperative planning by revealing the extent of the undermining of the pressure sore, the thickness of the fibrous scar at its base, and the size and status of the adjacent muscles.

Abscess↗

PubMed1983

Computerized tomography of pelvic osteomyelitis in patients with spinal cord injuries.

Computerized tomography (CT) was performed in 19 patients with spinal cord injury (SCI) who had large pressure sores and in whom other complications were suspected. CT detected the depth, extent, and degree of undermining of the edges of the pressure sores in 19 of 27 lesions. Conventional radiography detected four cases of pelvic osteomyelitis. CT detected eight additional cases of pelvic osteomyelitis, as well as eight clinically unsuspected peripelvic and intrapelvic abscesses. Technetium-99m bone scanning was not very helpful because of localization in chronic proliferative changes of bone and widespread foci of myositis ossificans, as well as in osteomyelitis. Gallium-67 scanning detected only one of six abscesses. It was not very helpful because of confusion of abscess and osteomyelitis with intense soft tissue swelling and cellulitis, which are often associated with pressure sores in patients with chronic SCI. CT was found to be, by far, the modality of choice for detection of pelvic osteomyelitis and abscess in patients with SCI.

Abscess↗

PubMed1982

Bilateral acetabular stress fractures in a paraplegic patient.

Advances in rehabilitation programs have enabled many paraplegic persons to take part in activities in which the risk of trauma and skeletal injuries is comparable to that in the general population. Stress or spontaneous fractures are known to occur mainly as a result of severe osteoporosis and uncontrollable motion following removal of leg braces. However, stress fractures due to repeated minor trauma or prolonged physical activity have not been previously observed in paraplegic persons. In this report, bilateral acetabular stress fractures are described in a young paraplegic man during the course of ambulation therapy. The pattern of ambulation in these patients, who attempt to walk with crutches while their legs are placed in braces, is one contributing factor to stress fracture. Because of the paucity of physical findings and absence of pain, these fractures may go unrecognized, which can lead to more serious complications.

Acetabulum↗

PubMed1982

Computed tomography of pressure sores, pelvic abscess, and osteomyelitis in patients with spinal cord injury.

Nine patients with spinal cord injury (SCI) and large pressure ulcers and other possible complications, were evaluated by computed tomography (CT), conventional radiography, tomography, bone scanning, gallium scanning, and sonography. CT revealed the depth, extent, and relationship of the ulcer-bed to the underlying structures in all 9 patients. CT also positively identified unsuspected intra- and extra-pelvic abscess and pelvic osteomyelitis in 4 patients each. Other modalities identified only 2 of these complications. We believe CT is the modality of choice for evaluation of these complications in SCI patients, because of its superior ability in evaluation of pressure sores and detection of pathologic changes in soft tissue and bone in the pelvic region.

Abscess↗

PubMed1973