Biomedical subjects
J Snigurowicz
Publications and source records attributed to J Snigurowicz.
[New evaluation of gammapathy in the light of explanation of common properties of antigenic immunoglobulins].
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[Protein disorders in the gamma system].
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[Incomplete immunoglobulins in immunocytoma].
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[Disorders of the gamma-globulin system. I. Cytological and immunological problems].
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[Immunochemical and biological properties of rapid monoclonal proteins of the IgG class].
Four proteins M class IgG were analysed in detail in view of their more rapid electrophoretic migration in starch gel among most proteins in this class. On the basis of these investigations two protein (from sera 212 and 244) corresponded to subclass IgG-4, one (serum 119) probably to IgG-4 with polyclonal impurities from other subclasses, and the fourth protein (from serum 210) to subclass 3 or 1. Since subclass IgG-4 contains the greatest amount of sialic acid residues of the remaining IgG subclasses finding of more rapid migration of the observed proteins seems to be due to this. A hypothesis has been put forward that if rapidly moving IgG do not belong to subclass 4 then they have, probably, atypically arranged carbohydrate groups, e.g. in Fab fragment. It was found also that the studied proteins M were carried during chromatography with DEAE cellulose only when a buffer with higher concentration of NaCl was used.
[Incomplete picture of protein disorders in IgD multiple myeloma].
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Acute myeloblastic leukemia in patients with multiple myeloma.
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[Osteosclerotic plasmocytoma (author's transl)].
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The analysis of factors influencing IgE level in the course of malignant lymphogranulomatosis with particular reference to the effects of splenectomy.
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[Comparison of diagnostic values of immunoelectrophoresis and other methods of determination of the class and type of M protein].
Comparative analysis of immunoelectrophoresis (IEF) and several other laboratory methods used in the diagnosis of protein M showed that IEF is a method of choice in the immunological characterization of this protein, with the exception of IgM macroglobulin where the interpretation of the heavy chain and particularly of the light chain give better results in dilution immunodiffusion or immunochromatography. When the results are uncertain the simplest additional method to IEF seems to be dilution immunodiffusion and the best method is isolation of the observed protein by column chromatography and repeated determination of purified protein by IEF. With all these methods the lambda type of protein M is more difficult to determine than the kappa type.