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Biomedical subjects

J Smith

Publications and source records attributed to J Smith.

At least 1,279 records · Page 71Linked to original sources
PubMed1981

Pruritus of cholestasis treated with plasma perfusion.

Patients with uncontrollable pruritus secondary to cholestatic liver disease were subjected to plasma perfusion in an attempt to remove the toxins responsible for this symptom. The improvement in the degree of pruritus was dramatic and surprisingly long-lasting in five of six patients. One patient had a response more difficult to evaluate. Serum bile acids levels fell in all patients in whom pruritus improved but not in the patient who responded less favorably.

Adult↗
PubMed1981

Chronic ambulatory liver support by membrane plasmapheresis with on-line detoxification.

Blood cellular elements and plasma protein losses are minimal for membrane plasmapheresis with on-line sorbent detoxification. Frequent (6/sk), chronic (3 mos), and long-term (8 hr) perfusions are possible for patients studied. It is recommended in deficiency states involving low protein, hypocoagulability or potential hormonal imbalances that aggressive medical management be applied. With regard to system performance, plasma filtration properties improved by the application of the closed plasma circuit and membranes with superior sieving and filtration properties. The effect of plasma solutes on filtration properties has been noted. In PBC patients the influence of total cholesterol concentration is particularly striking. Significant reduction of FFA and improvement of PMR were achieved in combination with bilirubin removal in liver failure patients, while bile acids (cholyglycine) levels were significantly reduced in 3 of PBC patients who expressed a subjective improvement of about 90% following 3 consecutive treatments. Four of 5 liver failure patients showed improved mental status with one patient surviving.

Adult↗
PubMed1980

Joint finance--3: hope for the dark years.

For this concluding article on joint finance, Jef Smith, director of social services, Kingston-upon-Thames, gathered impressions from Newcastle, regional centre for the North-East, a city with a teaching hospital and many problems.

Social Welfare↗
PubMed1980

Joint finance--1: ripping the Lambeth canvas.

Jef Smith, director of social services for Kingston-upon-Thames, has been visiting various parts of the country to talk about joint finance with a range of local authority and health service practitioners. In the first of three articles he reports on issues posed in the London Borough of Lewisham.

London↗
PubMed1980

A low resolution structure for the histone core of the nucleosome.

Image reconstruction to 22 A resolution of the histone octamer (H3)2(H4)2(H2A)2(H2B)2 shows it to have a 2-fold axis of symmetry, and the overall shape of the left-handed helical spool on which to wind about two turns of a flat superhelix of DNA in the nucleosome. From this structure and the results of various cross-linking studies, we have deduced the arrangement of the individual histones. We propose that the (H3)2(H4)2 tetramer forms a dislocated disk which defines the central turn of DNA, while the two H2A-H2B dimers lie one on each face, each associated with about one half a turn.

Animals↗
PubMed1980

Primary osteogenic sarcoma of the vertebral column: a clinicopathologic correlation of ten patients.

In a review of more than 1000 patients with osteogenic sarcoma of bone, the vertebral column was the site of the primary tumor in 10 patients. The vertebral osteogenic sarcoma in 4 of the 10 patients was secondary; to Paget's disease of bone in 3, and to irradiation received for a prior cancer in 1. Frequently, cord compression caused severe neurologic symptoms. Prognosis was always poor. Seven patients died of their disease within a year of histologic diagnosis. The differential diagnoses between osteogenic sarcoma and three benign tumors are reviewed, osteoblastoma being the tumor most frequently confused with osteogenic sarcoma. The radiologic and histologic criteria for distinguishing between the two are discussed.

Adolescent↗
PubMed1980

Policy for early discharge after acute myocardial infarction.

Simple criteria were used to select a low-risk group of patients after acute myocardial infarction. The criteria depended on the presence or absence of diabetes, pulmonary oedema, serious rhythm disorders, and recurrent cardiac pain. Patients in the low-risk category with a suitable home environment were discharged from hospital after five to seven days (mean 6.2 days); they constituted 47% of the 267 hospital survivors over 18 months. Mortality in the selected patients was 2.4% at six weeks and 7% at one year. Most complications preventing early discharge were identified on the first day. Provisional selection for a short hospital stay was made after two days, and 76% of those judged suitable at 48 hours remained free of complications. Early selection of a low-risk category is justifiable and of practical value, though subsequent events will delay discharge for some patients. All patients who died in hospital or within two weeks after infarction had developed overt complications by the end of the fourth day. The results suggest that a policy of hospital discharge after four days would be justifiable for a low-risk group selected by the present criteria.

Aged↗
PubMed1980

Indirect ignitioin of the endotracheal tube during carbon dioxide laser surgery.

We report here a case of an endotracheal tube fire occurring during carbon dioxide (CO2) laser surgery in the path of gases that support combustion. The tube was thought to be ignited by flaming tissue in close proximity to the tip and not directly by the laser. Tubes 1 cm away from an object repeatedly hit by the laser an easily be ignited indirectly. Aluminum-tape wrapping does not prevent this complication. We recommend caution when using the CO2 laser in the path of combustible gases in the presence of flammable objects.

Adolescent↗
PubMed1980

Hodgkin's disease complicated by radiation sarcoma in bone.

Seven patients after treatment of Hodgkin's Disease who developed bone sarcomas in the radiation field were seen at this centre over the past eight years. Radiation-induced sarcoma in bone in patients with Hodgkin's Disease is poorly documented. The large number of cases appeared to be an important new development and led to our review of all the patients with radiation-induced sarcomas (RIS) seen at this centre over the past 40 years. Thirty-seven patients with RIS in previously normal bone were found, and of these, only one patient with underlying Hodgkin's Disease, who was seen here 27 years earlier. Hodgkin's Disease and breast cancer were the most common primary underlying conditions and, as a result, the bones of the shoulder girdle were the commonest site of radiation-induced sarcoma. The clinical histories and radiographic findings of the eight patients with underlying Hodgkin's Disease are discussed in detail.

Adolescent↗