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Biomedical subjects

J Smith

Publications and source records attributed to J Smith.

At least 1,243 records · Page 69Linked to original sources
PubMed1982

The effect of salicylate on human leucocyte migration.

The effect of sodium salicylate, at concentrations obtained in vivo, on the random migration and chemotactic response of neutrophils and monocytes was examined. Incubation of cells in vitro increased neutrophil migration but decreased monocyte migration. However, both neutrophil and monocyte migration were significantly increased when obtained from normal individuals after ingestion of sodium salicylate. Salicylate also partly reversed the inhibition of neutrophil migration produced by aggregated immunoglobulin bound to the filter substrate. These effects of salicylate on leucocyte function may contribute to the anti-inflammatory activity of the drug.

Adult↗
PubMed1982

Fibrin deposits in Hodgkin's disease.

Fibrin deposits were observed in the involved lymph nodes and/or spleens of 15 patients with Hodgkin's disease by specific immunofluorescence and by electron microscopy. Two basic patterns of fibrin deposition were observed: 1) intercellular deposits, chiefly associated with nonneoplastic-appearing lymphoid cells and 2) deposits associated with the collagen fibers of young connective tissue. In addition, coarse fibrin deposits were observed in areas of necrosis, presumably a non-specific finding. Fibronectin was also observed in intercellular areas, but staining was less intense than for fibrin. Fibrin deposits were also observed in 3 of 6 cases of non-Hodgkin's lymphoma, indicating that the finding is not an exclusive feature of Hodgkin's disease. The pathogenesis and possible significance of fibrin deposition in Hodgkin's disease are related to earlier observations of activation of the coagulation system on neoplasia and cell-mediated immunity and to the possible role of fibrin, fibronectin, and their breakdown products in angiogenesis and fibroplasia.

Collagen↗
PubMed1982

An innovative technology for "random-access" sampling.

A major instrumental limitation to rapid, "random-access" clinical analysis has been cross-contamination at sampling and reagent probes. Use of an immiscible, nonreactive fluid as a positive barrier between the liquid sample and reagent and the interior and exterior surfaces of their respective probes provides an inert, deformable surface that both prevents carryover and ensures accurate delivery. Being totally nonreactive under clinical chemistry conditions, the fluid does not affect the ensuing analysis. Application of this technology to the Technicon RA-1000 (trademark of Technicon Instruments Corp.) system allows transfer of a liquid sample and any of 14 liquid reagents to the reaction vessel with a carryover of less than 1/10(6) with a precision (CV) of 0.5%. Its use provides for a rapid analysis rate of 240 tests per hour, and for transfer of microliter quantities of serum, with carryover of less than 1/8000, again at an average CV of 0.5%.

Autoanalysis↗
PubMed1981

Osteonecrosis in patients with malignant lymphoma: a review of twenty-five cases.

A retrospective study of 25 patients with malignant lymphoma who had osteonecrosis of either the femoral or humeral head(s) was undertaken. The common factor present among all patients was the administration of intermittent steroid-containing combination chemotherapy. Seventeen Hodgkin's disease patients received chemotherapy predominantly consisting of an alkylating agent, vincristine, procarbazine, and moderate amounts of prednisone. The non-Hodgkin's lymphoma patients were on various moderate dosage steroid-containing protocols, except three who received prolonged high-dose steroid-containing chemotherapy regimens. Sixteen of the 17 Hodgkin's disease patients and five of the eight non-Hodgkin's lymphoma patients received radiotherapy to the bones that subsequently developed osteonecrosis. Two of the three non-Hodgkin's lymphoma patients who were not irradiated were treated with high-dose steroid-containing chemotherapy regimens. Symptoms developed in patients 12 months and 32 months after completion of chemotherapy and radiotherapy, respectively. Osteonecrosis was a long-term complication of treatment between 1970 and 1979 and occurred in 1.6% of the Hodgkin's disease and 0.12% of the non-Hodgkin's lymphoma patients treated. The authors conclude that the patients at highest risk for this complication are those who receive both radiotherapy to the affected bone(s) and intermittent steroid-containing multiple drug chemotherapy.

Adult↗
PubMed1981

Preoperative angiocardiography in infants with tetrad of Fallot. Review of 36 cases.

Angiocardiograms in 36 infants with tetrad of Fallot were reviewed to determine which projections best displayed the anatomy. The occurrence of associated cardiovascular anomalies was also recorded. An additional ventricular septal defect was found in 14 percent (5 of 36), peripheral pulmonary stenoses in 30 percent (10 of 36) and surgically important coronary arterial abnormalities in 8 percent (3 of 36). This retrospective study indicated that optimal biplane angiocardiography should include: (1) right ventriculography in a sitting or hepatoclavicular view for demonstration of the right ventricular, infundibular, and pulmonary artery anatomy, (2) left ventriculography in the long axial oblique (cranially angled oblique) view for display of ventricular septal defects and coronary arteries, and (3) and aortogram at the valve level (oblique view) if coronary arteries are not well seen in the left ventricular study.

Angiocardiography↗