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Biomedical subjects

J Smith

Publications and source records attributed to J Smith.

At least 1,189 records · Page 66Linked to original sources
PubMed1983

An inside view. Clinical.

Explore the source record for details and available documents.

Cholangiopancreatography, Endoscopic Retrograde↗
PubMed1983

Probation linked supervised disulfiram in the treatment of habitual drunken offenders: results of a pilot study.

Sixteen habitual drunken offenders agreed to take disulfiram in liquid form under supervision as a condition of a probation order. They knew that failure to take medication, as with failure to observe any other condition of probation, could result in their being returned to court. Three defaulted but only two of the remainder committed further offences. Nine were entirely successful. At the end of the study the average period of abstinence for the whole group was 30 weeks compared with six weeks during the previous two years. Nine risked drinking alcohol but none suffered any serious consequences or side effects. This technique may be a judicially acceptable and more hopeful alternative to prison for these offenders.

Adult↗
PubMed1983

Cloning and expression of a porcine prorelaxin gene in E. coli.

A porcine prorelaxin gene has been constructed partly by synthetic means and partly from its natural messenger RNA. A gene coding for the 32 N-terminal amino acids including a chain initiator methionine codon (B gene) was synthesised and inserted in a plasmid at a site downstream from a tryptophan promoter in such a way that its expression is under the control of the trp promoter. DNA corresponding to the rest of the prorelaxin was prepared using reverse transcriptase extension of a primer complementary to relaxin mRNA and joined at a suitable restriction site to the B gene. Transformation of E. coli with this plasmid followed by suitable induction resulted in the synthesis of a new protein identified as prorelaxin by its size and its antigenic similarity to relaxin.

Amino Acid Sequence↗
PubMed1983

Gentamicin and tobramycin penetration into burn eschar. Pharmacokinetics and microbiological effects.

This study was designed to determine whether intravenously administered gentamicin sulfate and tobramycin sulfate penetrate into the eschar of patients with severe burns. In addition, each antibiotic's pharmacokinetics in serum and the effect on eschar microbiology were determined. Twenty patients with suspected burn wound sepsis received either gentamicin or tobramycin. The microbiology of the baseline eschar was determined and repeated on days 2, 4, and 7. All patients had measurable aminoglycoside tissue concentrations, and elimination from serum was not unusually rapid. Thirteen patients had baseline eschar cultures positive for Pseudomonas aeruginosa or Serratia marcescens; eight patients were initially bacteremic. Pseudomonas aeruginosa strains were sensitive to both antibiotics and usually declined in concentration with time or were eliminated; the more drug-resistant isolates of S marcescens persisted or caused super-infection and bacteremia. Aminoglycoside antibiotics penetrate into burn eschar and appear to have a substantial effect on eschar microbiology.

Adolescent↗
PubMed1983

A factor analytic study of screening scales of adjudicated delinquent males and females.

Obtained a factor analysis of demographic and behavioral variables from self-ratings and observations of trained raters on a sample of 200 incarcerated delinquents, which resulted in eight identifiable factors with eigenvalues over 1.0. These were described as: The undersized youthful offender with emotional problems, the aggressive threatening offender, the drug subculture repeat offender, the neurotic polyabuse offender, the institutionally unadjusted offender, the bright offender, the immature neurotic offender, and the "established" psychopathic offender. Results provide understanding of the relationships and disparities between self-ratings, the ratings of others, and demographic variables.

Adolescent↗
PubMed1983

tRNA-rRNA sequence homologies: evidence for a common evolutionary origin?

Many tRNAs of E. coli and yeast contain stretches whose base sequences are similar to those found in their respective rRNAs. The matches are too frequent and extensive to be attributed to coincidence. They are distributed without discernible pattern along and among the RNAs and between the two species. They occur in loops as well as in stems, among both conserved and non-conserved regions. Their distributions suggest that they reflect common ancestral origins rather than common functions, and that they represent true homologies.

Base Sequence↗
PubMed1983

Public opinion and the privatization of welfare: some theoretical implications.

The social policy of the Thatcher government is characterized by an abrupt shift in the direction of the private sector. To what extent does this reflect what people want? The Institute of Economic Affairs conclude from the only suitable national opinion survey that such a move is strongly supported. Our reanalysis of their data shows that this strand in public opinion can coexist with, and need not contradict, an equal public enthusiasm for state welfare. Such results have important implications for our understanding of social policy. We conclude, therefore, with a discussion of contrasting marxist and liberal accounts which seeks to show that the evidence of ambivalence in popular attitudes about the welfare state supports particular developments in theory.

Analysis of Variance↗
PubMed1983

Uses and selection of equipment for engineering control monitoring.

Control monitoring (continuous multipoint monitoring of workplace air) has been used in a number of industries to help control worker exposure to a wide variety of contaminants. Control problems were identified and effective control has been maintained by keeping workers and management aware of pollutant levels in the workplace. To be used effectively, the control monitoring system must be viewed as an integral part of workplace control. In this report, the general uses of control monitoring equipment are given, the factors to be considered in choosing equipment for control monitoring purposes are discussed, and a number of advances such as the development of sampling and data acquisition and display components that would help to promote the future use of control monitoring equipment are given. The role of control monitoring in workplace control is examined by looking at the interactions of the control monitoring system with the other elements of workplace control (engineering control devices, work practices, and personal protective equipment).

Air Pollutants↗
PubMed1983

Measurement of muscle mass in humans: validity of the 24-hour urinary creatinine method.

Measuring muscle mass is an important component of the nutritional assessment examination and a suggested index of this body space is the 24-h urinary excretion of creatinine. The method originated from studies in a variety of animal species in whom early workers found a parallelism between total body creatine and urinary excretion of creatinine. Assuming that nearly all creatine was within muscle tissue, that muscle creatine content remained constant and that creatinine was excreted at a uniform rate, an obvious "corollary" was that urinary creatinine was proportional to muscle mass. The so-called "creatinine equivalence" (kg muscle mass/g urinary creatinine) ranged experimentally from 17 to 22. One of the limiting factors in firmly establishing this constant and its associated variability was (and is) the lack of another totally acceptable noninvasive technique of measuring muscle mass to which the creatinine method could (or would) be compared. An improved understanding of creatine metabolism and a variety of clinical studies in recent years has tended to support the general validity of this approach. However, specific conditions have also been established in which the method becomes either inaccurate or invalid. While creatinine excretion may serve as a useful approximation of muscle mass in carefully selected subjects, there remains a need for accurate and practical indices of muscle mass for use in the individuals in whom the method cannot be reliably applied.

Adult↗