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Biomedical subjects

J Skrzypek

Publications and source records attributed to J Skrzypek.

At least 19 recordsLinked to original sources

Segmenting textures using cells with adaptive receptive fields.

Textural segmentation plays an important role in the figure-ground discrimination process. Evidence from neuroscience and psychophysics suggests that the segregation of texture patterns composed of oriented line segments is strongly influenced by the orientation contrast between the patterns (Nothdurft, Vision Res. 31, 1073-1078, 1991). In contrast to models available in the literature, this paper presents a neural network architecture for textural segmentation that can adaptively delimit the boundaries of uniformly textured regions. Cells with adaptive receptive fields encode uniformly textured regions by diffusively interpolating the estimates of feature orientations across the image. Orientation contrast boundaries are detected at gradients across the interpolated regions to produce the final segmentation. Consistent with neurophysiological data from simple and complex cells sensitive to static and moving textural patterns (Hammond and MacKay, Exp. Brain Res. 30, 275-296, 1977), the present model suggests that preattentive textural segregation can be performed by early visual processes localized to areas V1, V2, and perhaps V3 or V5. The computational results further support the idea that textural segmentation should not be thought of as a 'static' process, but as a system that employs cells with context-dependent response characteristics (Gilbert and Wiesel, Vision Res. 30, 1689-1701, 1990), here modeled as adaptive receptive fields.

Adaptation, Ocular

[levels of erythropoietin in serum of patients with primary hyperparathyroidism].

UNLABELLED: The present study aimed assess the relationship between erythropoietin (EPO) and parathormone (PTH) secretion in patients with primary hyperparathyroidism (PHP). Seventeen patients with PHP and 24 patients with uncomplicated cholelithiasis were examined before and during 14 days after surgical treatment. In PHP patients plasma EPO levels were significantly higher than in patients with cholelithiasis (31.5 + 4.3 vs 14.1 + 0.9 mU/ml, p < 0.01). After cholecystectomy transient increase of plasma EPO level was noticed postoperatively during the first 6 days. Such an increase of plasma EPO was absent in PHP patients after removal of the cause of primary hyperparathyroidism. Only in PHP patients a significant negative correlation was found preoperatively between plasma EPO level and Hct value or creatinine clearance respectively. CONCLUSIONS: 1. Patients with PHP are characterized by significantly elevated plasma EPO levels which are related to the degree of anaemia and decrease of GFR. 2. In patients with PHP presence of significant relationship between EPO and PTH secretion could not be proven.

Adult

[Changes of thyroid hormone levels in the perioperative period in patients with various types of goiter].

The thyroid hormone level was studied in the perioperative period in patients with various types of goitre. The clinical material comprised 85 patients treated surgically for nodular neutral goitre, nodular hyperactive goitre, Graves-Basedow disease, and cholecystolithiasis. The determination of total and free thyroid hormone blood serum levels was carried out in three periods of time, that is 4-5 days before operation, immediately after operation, and on the fifth day after operation. The obtained results led us to reaching the following conclusions: 1. Achieving of clinical euthyroid state in patients with Graves-Basedow disease during preoperative preparation with thyrostatic drugs was connected with the decrease of total and free thyroid hormone levels below the lower range of normal values which persisted immediately after, and on the 4th-5th day after operation. 2. During operation no significant increase was found of serum thyroid hormone levels. 3. On the 4th-5th day after operation, especially in patients with nodular neutral goitre and cholecystolithiasis a tendency was observed for a drop of triiodothyronine level, especially of its free fraction level.

Adult

[Hypercalciuria and primary hyperparathyroidism in patients with kidney calculi. I. Hypercalciuria].

In 1819 patients with active or non active respectively nephrolithiasis the following parameters were assessed: plasma level of calcium, phosphate, and uric acid and urinary excretion of calcium, phosphate, oxalate, uric acid and creatinine. These parameters were estimated after 5 days of diet containing 400 mg of calcium, 800 mg of phosphate, 100 mg of purines and 40 g of proteins. In 3/4 of all examined patients at least one lithogenic factor was present. More than 40% of patients showed presence of hypercalciuria. Among these patients in 68% renal in 17% absorptive and in 15% undefined hypercalciuria was diagnosed. Patients with active nephrolithiasis showed a similar frequency of hypercalciuria but more profound abnormalities of Ca P metabolism than patients with non active renal stone disease.

Adolescent

[Hypercalciuria and primary hyperparathyroidism in patients with kidney calculi. II. Primary hyperparathyroidism].

Among 1819 patients with renal stone disease 44 cases with primary hyperparathyroidism (p.h.p.) were diagnosed. In all cases the diagnosis of php was confirmed by histomorphological examination. In 34 patients with php solitary adenoma was found, in 5 patients an adenoma with concomitant hyperplasia of the parathyroid glands, in 2 patients hyperplasia and in 3 patients carcinoma of the parathyroid glands. Hypercalcemia was found in 86% of patients, while elevated plasma levels of PTH in 90% of patients with php. Not in all patients PTH secretion was entirely autonomous. No significant correlation was found between plasma levels of PTH and kind of pathology of the parathyroid glands as well as clinical feature of php respectively.

Adult

[Migration inhibition test with thyroid membrane antigen in Graves-Basedow disease and nodular goiter].

The evaluation of the migration inhibition test with thyroid membrane antigen was carried out in 20 patients with Graves' disease, 13 patients with neutral nodular goiter and 13 healthy subjects. A significant inhibition of migration by thyroid antigen as compared to the control group was demonstrated only in the patients with Graves' disease (the value of the migration index was 0.57 +/- 0.07). The respective value was 0.79 +/- 0.16 in patients with nodular goiter and 0.85 +/- 0.11 in healthy subjects. The results obtained indicate the practical value of the migration inhibition test in diagnosing the thyroid diseases having an autoimmune background.

Adult

Electrical coupling between horizontal cell bodies in the tiger salamander retina.

We studied lateral interactions between horizontal cells in the tiger salamander retina in order to determine the underlying mode of synaptic transmission. Pairs of cells, visually identified by inspection of the in vitro retinal slices, were impaled with two separate electrodes and the transmission between them was examined by injecting current into one cell while recording the resulting voltage response from the other soma. It was found that coupling between horizontal cells remained intact and even increased somewhat during the light response and in the presence of cobalt or acetylcholine. It was also observed that a fluorescent dye injected into one cell would often migrate and stain neighbouring horizontal cells. These results suggest that synaptic transmission between horizontal cell bodies is mediated mainly by electrotonic conduction. The increase in apparent coupling observed under certain experimental conditions can be explained by the increase in input resistance of each horizontal cell.

Acetylcholine

Lateral interactions in absence of feedback to cones.

1. The reversal potential of the surround response in cones was measured by inactivating the outer segment, polarizing the cone to different potential levels with extrinsic current, and flashing a full-field stimulus. This elicited a 3- to 4-mV depolarizing response at the normal -40-mV dark level. Its reversal potential was typically near -60 mV. 2. Cones were also polarized by a steady center light while flashing an annulus. The annular response was suppressed when the cone was polarized to near -60 mV. No reversal was measured, presumably because the maximum center light response could not exceed -60 mV. 3. Items 1 and 2 provide a method for measuring surround responses in cells post-synaptic to the cones in the absence of the surround response in the cones themselves; cone surround responses are suppressed although some horizontal cell surround responses are enhanced (item 6) at high center intensities that polarize the cones to near -60 mV. 4. Bipolar cells of both types (depolarizing and hyperpolarizing) generate a surround response that opposes the center response. In both bipolar cell types, the surround response is completely suppressed near center intensities that suppress the surround response in the cones. 5. Narrow-field horizontal cells behave like cones and bipolar cells; the depolarizing surround response is suppressed at high center intensities bright enough to suppress the cone surround response. At higher center intensities the surround response becomes hyperpolarizing, presumably due to direct coupling to peripheral horizontal cells. 6. Broad-field horizontal cells always hyperpolarize in response to surround illumination. The hyperpolarizing surround response is augmented at high center intensities, presumably because the depolarizing component, initiated in the cones, is suppressed, while the direct coupling to peripheral horizontal cells remains intact.

Animals