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Biomedical subjects

J Skinner

Publications and source records attributed to J Skinner.

At least 109 records · Page 6Linked to original sources
PubMed1975

The histological classification of duodenitis in fibreoptic biopsy specimens.

Recent advances in biopsy techniques using fibreoptic instruments have refocussed attention on the condition on non-specific duodenitis. Investigation of the topography of duodenitis and its relationship to possible aetiological factors and to duodenal ulcer calls for a proper histological classification. Such a classification is proposed based on the subjective appearances and a quantitative examination of 747 fibreoptic biopsy specimens in a wide range of clinical conditions.

Biopsy↗
PubMed1975

The effects of hypophysectomy and of bovine growth hormone on the responses to testosterone of prostate, preputial, Harderian and lachrymal glands and of brown adipose tissue in the rat.

The relative responses to testosterone of the prostate, preputial, Harderian, and lachrymal glands, the seminal vesicles and the brown adipose tissue, have been compared in litter-mate, castrated and hypophysectomized-castrated rats, with or without treatment with bovine GH. The responses of both prostate and preputial glands, though not the seminal vesicles, were reduced by hypophysectomy, and restored by GH. Growth hormone had some independent action on the preputial glands, but most of its effect was synergistic with testosterone. The respinse of brown adipose tissue to testosterone was similarly reduced by hypophysectomy, but was not restored by the GH. The weights of the Harderian and lachrymal glands were not affected by castration, but they were considerably reduced by hypophysectomy. Growth hormone had a slight restorative effect on the Harderian glands, but none on the lachrymal glands.

Adipose Tissue, Brown↗
PubMed1975

The synergistic action of alpha-melanocyte-stimulating hormone and testosterone of the sebaceous, prostate, preputial, Harderian and lachrymal glands, seminal vesicles and brown adipose tissue in the hypophysectomized-castrated rat.

Alpha-Melanocyte-stimulating hormone was shown to act synergistically with testosterone to stimulate the sebaceous, prostate and the seminal vesicles in hypophys-ectomized-castrated rats. The sebaceous glands differed from the other three organs in that alpha-MSH not only acted synergistically, but also had a significant effect which was independent of the presence of exogenous testosterone. The response of the brown adipose tissue to testerone, considerably reduced by hypophysectomy, was not restored by alpha-MSH. The Harderian and lachrymal glands were also pituitary-dependent and their weights in hypophysectomized-castrated rats were not restored by alpha-MSH.

Adipose Tissue, Brown↗
PubMedDate not supplied

An analysis of two-period crossover designs with carry-over effects.

The crossover design is a type of longitudinal study with subjects receiving different treatments in different time periods. When carry-over effects are absent, the usual crossover design is structured so that all the information about treatment effects is contained in the within-subject contrasts; standard analyses are based on these within-subject contrasts and ignore any between-subject information. With carry-over effects present these standard analyses can be very inefficient, especially for suboptimal designs. We describe alternative approaches based on methods for the analysis of longitudinal data.

Longitudinal Studies↗
PubMedDate not supplied

Infectious complications in pediatric patients undergoing transplantation with T lymphocyte-depleted bone marrow.

We performed a retrospective study of the infectious complications in 14 pediatric patients undergoing transplantation with T lymphocyte-depleted bone marrow. The purpose of this study was to document the infectious complications encountered in these patients and to ascertain whether or not they appeared to be more susceptible to any particular infections. It was found that all 14 patients developed infectious complications following transplantation: there were a total of 24 bacterial infections among 11 patients, 21 fungal infections among 11 patients, 2 parasitic infections and 4 viral infections. The viral infections included two cases of infection with cytomegalovirus, one of which manifested as encephalitis and pneumonia, and one case of possible infection with Epstein-Barr virus, which included clinical findings compatible with a lymphoproliferative disorder. These patients were at an increased risk to certain viral infections and particular attention must be paid to the prevention, diagnosis and treatment of these infections.

Adolescent↗
PubMedDate not supplied

Medicare reform: who pays and who benefits?

As Medicare's share of federal spending and gross domestic product (GDP) rises, the program may have increasingly important consequences not only for the health of Americans but also for their net income and financial well-being. We use incidence analysis to study payments and benefits in Medicare to various generations and income groups. We find that Medicare actually provides larger net dollar transfers to wealthier beneficiaries, although the "insurance value" of these dollars is greater for low-income households. We then evaluate a range of proposed Medicare reforms with regard to their impact on the distribution of both health care and disposable income.

Aged↗
PubMedDate not supplied

Use of glass beads and CF 11 cellulose for removal of leukocytes from malaria-infected human blood in field settings.

Passage of malaria-infected blood through a two-layered column composed of acid-washed glass beads and CF 11 cellulose removes white cells from parasitized blood. However, because use of glass beads and CF 11 cellulose requires filtration of infected blood separately through these two resins and the addition of ADP, the procedure is time-consuming and may be inappropriate for use in the field, especially when large numbers of blood samples are to be treated. Our modification of this process yields parasitized cells free of contaminating leukocytes, and because of its operational simplicity, large numbers of blood samples can be processed. Our procedure also compares well with those using expensive commercial Sepacell resins in its ability to separate leukocytes from whole blood. As a test of usefulness in molecular biologic investigations, the parasites obtained from the blood of malaria-infected patients using the modified procedure yield genomic DNA whose single copy gene, the circumsporozoite gene, efficiently amplifies by polymerase chain reaction.

Adenosine Diphosphate↗