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Biomedical subjects

J Silva

Publications and source records attributed to J Silva.

322 records · Page 18Linked to original sources
PubMedDate not supplied

[Ossifying arachnoiditis in spondyloarthropathy patient].

A 52-year-old man, with the diagnosis of Ankylosing Spondylitis, since the age of 22, was admitted due to progressive neurological symptoms that had started two years before: paresthesias, impaired sensation and muscle weakness of the lower limbs; burning abdominal and lumbar pain; together with bladder, bowel and sexual dysfunction. Imaging investigations revealed severe lesions from D1 to L5: epidural calcification; spinal cord compression and syringomyelia. Based on this case, the authors review the neurological complications of Ankylosing Spondylitis.

Arachnoiditis↗
PubMedDate not supplied

[Bladder schistosomiasis. Report of a case].

OBJECTIVES: We report an additional case of schistosomiasis of the urinary bladder, an unusual parasitic infection in our setting, with special reference to the histomorphological findings that permitted its diagnosis. METHODS: Biopsy was performed via cystoscopy and bladder tissue was obtained from an area in the trigone with an abnormal appearance. RESULTS: Microscopic examination of the biopsy specimen revealed eggs of the parasite Schistosoma haematobium. CONCLUSIONS: The present case shows the importance of close collaboration between clinicians and pathologists and the usefulness of cystoscopy for diagnosis in urological patients.

Humans↗
PubMedDate not supplied

[Transferrable broad-spectrum beta-lactam resistance in Klebsiella pneumoniae R-3455].

Bacterial resistance to antimicrobial agents is a common problem observed in hospitals. We characterized a clinical isolate of Klebsiella pneumoniae (R-3455) which was resistant to high concentrations of broad spectrum beta-lactams, aminoglycosides, fluoroquinolones, chloramphenicol and tetracycline. Conjugation experiments showed that the multiresistance could be transferred to Escherichia coli J53-2 receptor strain. The transconjugant X-3455 was resistant to all antibacterials assayed in R-3455, except to fluoroquinolones. We found that both strains R-3455 and X-3455 produced a beta-lactamase which was sensitive to clavulanic acid. Southern hybridization and PCR analysis showed the presence of at least, a TEM type beta-lactamase gene in both strains.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Fluorescent products in the crystalline lens of type ii diabetic patients].

A body of evidence suggests that glycation of proteins and the resulting fluorescent products take part in the late complications of diabetes. The purpose of this study was to analyse the fluorescence of lens soluble proteins from diabetic patients. Soluble proteins were obtained from lens with cataract from 20 type II diabetic patients and from 21 non diabetic controls with similar age. The fluorescence of the soluble fraction (EX-360 nm, EM -454 nm) was quantified as a parameter for glycation end products. The glycation of plasma proteins was quantified by fructosamine levels. The fluorescence mean in the group of diabetics was about twice the non diabetic value (p < 0.01). The fluorescence in the diabetics with retinopathy was higher than that of diabetic without retinopathy (p < 0.01). Fructosamine levels were: diabetics 3.1 +/- 1.1 mM, non diabetics 1.9 +/- 0.8 mM (p < 0.001). The results suggest the involvement of fluorescent products, resulting from glycation of proteins, in lens opacification in diabetic patients.

Aged↗