Biomedical subjects
J Sikora
Publications and source records attributed to J Sikora.
[Detectability of cervical cancer in a provincial diagnostic center with particular reference to women below 30-year of age].
Explore the source record for details and available documents.
[Sudden death in the course of non-specific interstitial Fiedler type myocarditis].
Explore the source record for details and available documents.
[Intertrochanteric varisation and displacement osteotomy in coxarthrosis. Indication, technic and results].
Explore the source record for details and available documents.
[A case of operative treatment of prostatic sarcoma].
Explore the source record for details and available documents.
The role of monocytes/macrophages in TCR-zeta chain downregulation and apoptosis of T lymphocytes in malignant pleural effusions.
The aim of this study was to assess alterations of zeta chain expression and their relation to apoptosis of T lymphocytes. T lymphocytes were obtained from malignant pleural effusions (MPE) of 15 patients. The work focused on TCR-zeta chain expression, apoptosis of T lymphocytes, and on the content of monocyte/macrophages in effusions. Analysis was performed using three color flow cytometry combining CD3, TCR-zeta and TUNEL reaction. The content of tumor and monocyte/macrophage cells has been determined using CD3, CD14, and cytokeratins, as markers of distinct cell subpopulations. Our findings strongly indicate that decreased zeta chain expression in T cells depends on the content of monocyte/macrophage cells, and that the range of the decrease is inversely proportional to the number of monocytes/macrophages in the effusion. Those having low zeta chain expression were the main subpopulation of T cells undergoing apoptosis. These data suggest that decreased zeta chain expression in T cells in MPE may be related to the abundance of monocyte/macrophages in effusions.
[Neuropsychiatric disorders caused by tetra-ethyl lead poisoning].
Explore the source record for details and available documents.
[Neuropathological changes in the course of experimental poisoning with ethyl gasoline].
Explore the source record for details and available documents.
The effect of drugs interacting with serotonergic 5HT3 and 5HT4 receptors on morphine place conditioning.
The effect of 5HT3 and 5HT4 active compounds on the motivational properties of morphine has been examined in the place conditioning (PC) paradigm using unbiased procedure. Place conditioning with morphine produced significant place preference. Pretreatment with the DAU 6285 (mixed 5HT3 antagonist--5HT4 antagonist) abolished morphine-induced PC. Ondansetron (selective 5HT3 antagonist) attenuated morphine place preference at the dose of 0.1 mg/kg. BIMU 8 (mixed 5HT3 antagonist--5HT4 agonist) failed to modify morphine PC in the 0.001-0.1 mg/kg dose range. While ondansetron given alone failed to produce place conditioning, pairing of BIMU 8 (0.001 mg/kg) induced significant place preference. On the other hand, animals were frequently avoiding compartment paired with the injection of DAU 6285. These findings suggest that 5-hydroxytryptamine by means of 5HT4 receptors mediates appetitive properties of morphine induced-stimuli and suggest that 5HT4 receptor may be involved in the brain reward and reinforcement processes.
[Bronchoalveolar lavage in patients with pulmonary sarcoidosis and advanced radiologic changes].
The study material was made up of 20 patients with stage I pulmonary sarcoidosis in different state of activity. BAL was carried out through a bronchofiberscope using four aliquots 50 ml each, immediately aspirated after introduction into siliconized vials. BAL induced side effects were not seen. The returned fluid was centrifuged and the cell differential count was carried out. 11 patients (55%) demonstrated a high lymphocytic count. The degree of lymphocytosis did not correlate with abnormalities in respiratory function. The degree of lymphocytosis did slightly correlate with disease activity. Thus serial BAL studies might be useful in therapy monitoring. The high lymphocytosis should be carefully interpreted and can not be the only indication for instituting steroid therapy.
Effects of 5-HT3 receptor antagonists on ethanol-induced hyperlocomotion in mice.
We tested how 5-HT3 receptor antagonists, tropisetron (TR) and ondansetron (ON) affect the hyperlocomotion induced by single dose of ethanol EtOH) in mice. EtOH in a dose-dependent manner (0.5-2.0 g/kg ip) increased locomotion of mice. The effect of 2.0 g/kg of EtOH was reduced by ON (0.1 mg/kg and 1.0 mg/kg sc) and, to the lesser extent and only in limited dose range (0.01 mg/kg) by TR. Tropisetron (but not ON) increased concentrations of EtOH in the blood. The data suggest that 5-HT3 receptor is involved in EtOH-induced hyperlocomotion.