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Biomedical subjects

J Siegfried

Publications and source records attributed to J Siegfried.

At least 91 records · Page 5Linked to original sources
PubMed1978

[Electric stimulation in the treatment of chronic pain].

Electrical stimulation in the treatment of chronic pain, though an old method, has become very attractive again in the last ten years. The use of transcutaneous, percutaneous and implanted stimulating devices is discussed. Although the method is sometimes contested and the mechanism of action not yet clear, it can no longer be ignored. Even if the clinical successes are in the long run only limited, the application of the method must be considered. If only one in three or four patients is still painfree after a few years by the use of an implanted electrical stimulating device, it is a tremendous boon for this particular patient when all other kinds of conservative and surgical treatment have failed.

Afferent Pathways↗
PubMed1978

[Neurosurgical treatment of symptomatic and atypical facial neuralgias (author's transl)].

Symptomatic trigeminal neuralgia, especially in multiple sclerosis, can be successfully eliminated by percutaneously controlled thermocoagulation of the Gasserian ganglion. Atypical facial neuralgias are only improved by this intervention if secondary pains accompany the persistent pains. All neurosurgical procedures must be avoided with persistent unclassifiable pains in the area of distritubion of one or more branches of the trigeminus, especially in young people. The problem of neurosurgical treatment of analgesia dolorosa has not yet been finally solved.

Denervation↗
PubMed1978

Quantitative analysis of intracerebral recordings in epilepsia partialis continua.

A 14-year-old female with epilepsia partialis continua was explored stereo-electroencephalographically (SEEG). SEEG, EEG and EMG were recorded synchronously on a 32-channel machine and stored on magnetic tape for off-line analysis. The beginning of the myoclonus was used as trigger for the analysis of the intracerebral activity, which was analysed by averaging. Thereby the generating potentials of the jerks became evident. They had different maxima and latencies relative to the facial and hand muscles: that for m. orbicularis oculi was located in the precentral gyrus, the beginning of its positive deflection was 17 msec earlier than the muscle action potential; that for the thenar muscles had a latency of 24 msec, appeared at first in the premotor cortex and with a slight delay, but with greater amplitude in the corona radiata and capsula interna. Stimulation of the lateral area 4 elicited myoclonus which corresponded to the spontaneous one in distribution and latency. Stimulation of the thalamic VL nucleus had no effect. During deep sleep the frequency of the myoclonus was diminished. REM sleep was preceded and followed by a definite increase of jerking. The pattern, topography and latency of the generating potentials in waking and sleeping were very similar. In this way quantitative evidence of the neocortical origin of Epc is given and therefore a precise delineation of the epileptogenic focus.

Adolescent↗
PubMed1978

Electrical spinal cord stimulation for spastic movement disorders.

Spinal cord stimulation seems today a promising method to improve spasticity. The experiences of two different clinics (Zürich and Freiburg i.Br.) are reported with long-term assessment up to 28 months. The objective data with measurement of stretch and H reflexes support the clinical results. An experimental study on animals does not permit a definitive explanation, but some hypotheses can be suggested.

Adult↗
PubMed1978

[Stimulation of the periaqueductal gray matter for pain : electrical activity and evoked potentials (author's transl)].

There is some evidence that stimulation of the periaqueductal gray matter produced analgesia is accomplished by the activation of neuronal systems where endorphins are thought to be transmittors. However, the neurophysiological mechanism of this stimulation is not elucided. In this preliminary paper, the spontaneous and the evoked electrical activity has been studied in 3 patients operated on with implantation of an electrode in the periaqueductal gray matter for chronic pain. Particularly interesting are the pronounced decrease of the evoked potentials in the sensory nucleus of the thalamus after stimulation of the periaqueductal gray matter.

Aged↗
PubMed1977

Long-term assessment of stereotactic dentatotomy for spasticity and other disorders.

In the 60's stereotactic electrocoagulation of the dentate nucleus became a promising approach in the neurosurgical treatment of muscular hypertonicity, particularly when spasticity was evident. A relatively satisfactory improvement of spasticity has been reported earlier as a result and the authors were supporting these clinical results in previous publications. A long-term assessment of the results obtained in a large series of patients would permit a better evaluation of the effect of the operation. Analysing 109 stereotactic electrocoagulations of the dentate nucleus on 50 patients mainly in cases of cerebral palsy over a period of more than 10 years (most patients underwent a bilateral dentatotomy), the authors give a more realistic appreciation of the results, which depend on the criteria chosen. In 30% of the cases a clear improvement in the spasticity was obtained, and in 50% of all cases, nursing and rehabilitation were facilitated. The stereotactic dentatotomy never completely cured the spasticity and spectacular results were never observed, but the operation can be performed without complications and an unexpected neurological deficit did not occur. The role of the stereotactic dentatotomy and other neurosurgical methods in the treatment of spasticity has to be evaluated more critically.

Adolescent↗
PubMed1977

500 Percutaneous thermocoagulations of the Gasserian ganglion for trigeminal pain.

Five hundred patients with trigeminal pain underwent percutaneous thermocoagulation of the Gasserian ganglion. Of these 416 had classical trigeminal neuralgia, 49 had atypical facial pain and 35 had symptomatic trigeminal neuralgia. The patients ranged in age from 20 to 92 years. These patients have been followed for from eight to 57 months. The beneficial results of this operation and the complications are presented.

Adult↗
PubMed1976

Stereo-electroencephalographic exploration and epilepsia partialis continua.

Somatomotor status epilepticus in infatnts consisting of continous repetitive clonic jerks as a sequel of involvment of the sensorimotor area cortex has rarely been explored by multiple depth electrodes. The authors report 3 cases, which were examined stereo-electroencephalographically. Two girls, a 5 year old and a 3 year old showed sustained jerks of one foot with intermittent Jacksonian seizures. Both had a primary epileptogenic focus in the medial prerolandic and postrolandic cortex. The third case, an 8 year old girls, was a borderline case of Kozevnikov epilepsy. All 3 patients were operated on following the stereo-electroencephalographic exploration and the focus was removed. The study shows that it is possible to explore children with depth electrodes and that this exploration is the safest way to localize a focus and, consequently to cure the patient by surgery.

Brain Mapping↗
PubMed1976

Mortality among Parkinson patients treated with L-dopa combined with a decarboxylase inhibitor.

Since L-dopa in combination with a decarboxylase inhibitor is currently the most effective therapy available for treatment of Parkinson's disease, the authors compare the actual causes of death in a large series of treated Parkinson patients with a normal population and with previous studies. This investigation shows that the mortality of correctly treated Parkinson patients lies within the range of the expected mortality of a group of a normal population comparable in age and sex. The risk of death for a Parkinson patient is therefore no longer higher than for the normal population.

Adult↗