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Biomedical subjects

J Shimazaki

Publications and source records attributed to J Shimazaki.

At least 397 records · Page 22Linked to original sources
PubMed1984

[Prostatic acid phosphatase by enzymeimmunoassay].

We measured prostatic acid phosphatase levels by enzymeimmunoassay (PAP-EIA). Intraassay reproducibility of PAP-EIA was markedly good. In thirty normal males, PAP-EIA levels ranged from 0.24 ng/ml to 3.3 ng/ml, mean and S.D. being 0.94 ng/ml, 0.50 ng/ml, respectively. We made the upper limit of PAP-EIA for the normal range, 1.94 ng/ml (Mean + 2 S.D.). O 40 patients with untreated prostatic cancer, 34 patients (85%) gave positive results (1/3 33% of stage A, 3/4 75% B, 10/11 90% C, 20/22 90% D). One out of 12 patients with BPH, and one out of 11 with prostatitis gave positive results. The false positive rate was 9%. PAP levels of 324 samples from 111 patients with prostatic cancer were measured by EIA and radioimmunoassay (RIA). A significant correlation was noted between EIA and RIA (r = 0.997 p less than 0.001).

Acid Phosphatase↗
PubMed1984

Indomethacin suppresses prolactin release in men.

Indomethacin administered intrarectally at a dose of 100 mg elicited a statistically significant decrease of serum prolactin level in men. Serum LH level was depressed slightly but the decrease was not statistically significant. There was no effect on serum FSH concentration.

Adolescent↗
PubMed1984

[Phase II study of UFT for malignant tumors of urinary organs].

Phase II Study of UFT was performed in 59 patients with malignant tumors of urinary organs in 5 Cooperative Study Institutions. Forty-nine patients out of 59 were evaluable for response according to Koyama -Saito's criteria. Complete response (CR) was recorded in 7 patients, partial response (PR) in 3, minor response in 2, no change in 27 and progressive disease in 10, respectively. The overall response rate was 20.4%. The response classified in terms of tumor type was as follows: 4 CR and 2 PR of 23 patients with bladder tumor, response rate of 26.1%; 1 CR and 2 PR of 10 patients with renal tumor, response rate of 30.0%; 1 CR of 12 patients with prostatic tumor, response rate of 8.3%. Side effects occurred in 22 (41.5%) out of 53 patients. The high incidence was mainly concerned with GI toxicity such as anorexia (24.5%), nausea and vomiting (9.4%), general malaise (9.4%), diarrhea (3.8%) and stomatitis (3.8%), respectively. Renal function disorder was not induced, and marrow depression and hepatic function disorder occurred at low frequency (1 case each).

Adult↗
PubMed1984

[The effects of prostaglandin synthetase inhibitor on male infertility].

From August 1979 to August 1981, 272 patients with the chief complaints of sterility visited our University Hospital. Flurbiprofen was administered to 40 of the 164 cases of idiopathic male sterility. Flurbiprofen of 120 mg was administered daily for 3 consecutive months. Drug use was discontinued in 2 cases because of severe digestive symptoms. Semen findings were compared before and after the medication. In the cases with sperm concentration over 10 X 10(6)/ml, sperm concentration and motility were improved in 26.9% and 23.1%, respectively. In the cases with sperm concentration under 10 X 10(6)/ml, sperm concentration and motility were effective in 8.3% and 25.0%, respectively. LH and FSH levels in blood were not different between before and after the administration. On the other hand, testosterone level in blood tended to increase a little, but not with statistically significance. Digestive symptoms and skin eruption were found in 4 cases and one, respectively.

Adult↗
PubMed1984

[A clinical observation on urogenital tuberculosis].

A clinical observation was made on 25 cases of urogenital tuberculosis experienced at the urological department of Chiba Prefectural Sawara Hospital between January 1973 and December 1982. They accounted for 0.28% of the 8,945 outpatients. There were 17 cases of urinary tuberculosis and 13 cases of genital tuberculosis. In urinary tuberculosis, the age distribution showed a peak in the fifties. There was a predominance in males. The patients in their twenties and fifties comprised 60% of the cases of genital tuberculosis. The kidney affected was predominantly the left kidney. Bladder tuberculosis was found in 7 cases. The majority of the epididymal tuberculosis were found in the right side. Bladder and renal symptoms were the chief complaints for 41.2% and 17.6%, of the cases, respectively. Thirty two percent of the patients had a history of tuberculosis. In cystoscopy, typical findings of tuberculosis were found in only 25% of the cases. Mycobacterium in urine could be detected in 33.3%. Accelerated blood sedimentation rate was detected in 65% of the cases. Pyelography revealed ureteral abnormality in the majority of the cases. Three of the 16 patients with renal tuberculosis underwent nephrectomy, and orchiectomy was performed on 6 of the 13 patients with epididymal tuberculosis.

Adult↗
PubMed1984

[Bladder cancer in elderly patients].

Seventy of the 205 patients treated for bladder cancer in the past 8 years were over 70 years old (older group). The male to female ratio was 2.2 in older group, and that for the younger group was 4.1. The incidence of high grade cancer was larger in the older group than in the younger group. The 5-year survival rate was 42% for the older group and 66% for the younger group. The older patients with superficial cancer died mostly because of other causes and those with invasive cancer died of cancer. Eight cases of high grade, low stage cancer were treated by TUR or radiation, and they were well-controlled.

Adult↗
PubMed1983

Relapse of androgen-dependent tumour of mouse (Shionogi Carcinoma 115) after castration and oestrogen treatment.

To elucidate relapse of hormone-dependent tumour, mice bearing androgen-dependent carcinoma (SC 115) underwent castration or received oestrogen treatment. Since SC 115 consisted of two types of cells, androgen-sensitive round cells and -insensitive spindle-shaped cells, changes in the ratio of the cellular population were examined. After castration, spindle-shaped cells increased temporarily as the tumour regressed, then the round cells increased significantly along with an increase in size of the tumour. Oestrogen treatment did not influence the population. Androgen dependency and the growth rate of round cells were generally preserved in the next generation. Therefore, relapse may occur by an increase in the number of androgen-sensitive round cells.

Androgens↗
PubMed1983

The incidence of cystinuria in Japan.

Screening tests for cystinuria were done in approximately 110,000 children and students. The rates of discovery were chemical cystinuria 920 to 1, cystine crystalluria 16,000 to 1 and homozygous cystinuria 18,000 to 1 (8,000 to 1 if a correction was made by the rates of performances of secondary screening and urinary amino acid assay). No stone formation was observed in a 7-year followup of 6 patients considered to be homozygotes. A correlation was observed between urinary cystine and urinary uric acid levels in 39 cases of chemical cystinuria.

Adolescent↗
PubMed1983

Effect of sex hormones on RNA synthesis of androgen-dependent mouse mammary tumor (Shionogi carcinoma).

To observe the effect of sex hormones on RNA synthesis of androgen-dependent tumors, mice of DD/S strain bearing androgen-dependent mouse mammary tumor (SC 115) were treated with the hormones, and RNA polymerase activities in isolated nuclei of the tumor were measured. The activity of RNA polymerase I in SC 115 was diminished to approximately 60% of the control level by castration, and it was restored to the precastrated level 12 hr after treatment with 0.2 mg of testosterone. While the activity of RNA polymerase II in the tumor was scarcely influenced by castration, it reached 150% of the castrated level 24 hr after administration of testosterone. In CS 1, a subline of SC 115 with partial loss of androgen dependency on growth, castration and testosterone treatment caused similar but less prominent effects on the activities of RNA polymerase. Administration of estradiol-17 beta to castrated animals also increased the activity of RNA polymerase I, but to a lesser degree than testosterone, in both SC 115 and CS 1. However, only SC 115 demonstrated an increase in RNA polymerase II after estrogen treatment.

Androgens↗
PubMed1983

Changes in cytosolic androgen receptor after administration of testosterone of androgen-dependent mouse mammary tumor (Shionogi carcinoma) and its sublines of altered androgen dependency.

The effect of testosterone treatment on the cytosolic androgen receptor in an androgen-dependent tumor (Shionogi Carcinoma 115, SC 115) and its sublines of altered hormone-dependency (CS 1, less androgen-dependent, and CS 2, androgen-independent) was examined. In all tumors examined a single, high-affinity binding to 3H-R 1881 was detected in cytosols. The size of the maximum binding sites was in the order SC 115, CS 1 and CS 2. Inhibition experiments revealed that the binding to 3H-R 1881 in cytosols of these tumors was attributable to the androgen receptor. The amount of the androgen receptor in cytosols was decreased at 1 hr after testosterone injection, then replenished gradually towards the pretreatment level. Depletion of the androgen receptor was dependent on the dose of testosterone administered. Multiple injections of testosterone depressed the replenishment of the receptor. Treatment with actinomycin D or cycloheximide did not alter the dynamics of the androgen receptor. Therefore, it was concluded that the depletion and replenishment of the androgen receptor in cytosols of the tumors were caused by receptor recycling. Because a similar pattern of depletion and replenishment of the androgen receptor was also observed in the less androgen-dependent tumors, the growth of tumors was felt to be unrelated to the receptor dynamics.

Animals↗
PubMed1983

In vitro effect of androgen on RNA synthesis in nuclei from androgen-independent subline of Shionogi carcinoma (CS 2).

By serial transplantation of CS 1, a subline of Shionogi carcinoma SC 115, to female mice, another subline was obtained and designated CS2. The subline showed a complete loss of androgen dependency on the growth of the tumor. When male mice bearing the tumor were castrated and treated with testosterone, the activity of RNA polymerase I in isolated nuclei from the tumor hardly varied during the period of the experiments (36 h), while the activity of RNA polymerase II exhibited a transient increase (about 40%) at 6 h after the testosterone injection. The results, together with the previous ones showing 80% and 40% increases in RNA polymerase I activity at 24 h after testosterone administration in the case of SC 115 (androgen-dependent tumor) and CS 1 (less androgen-dependent tumor), respectively, indicate that the stimulation of RNA polymerase I activity by androgen in the tumor tissues is closely related to the androgen dependency on the growth of the tumors.

Androgens↗