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Biomedical subjects

J Shibata

Publications and source records attributed to J Shibata.

At least 91 records · Page 5Linked to original sources
PubMed1984

Vocal rehabilitation by tracheogastric shunt method after pharyngolaryngoesophagectomy for malignancy.

After pharyngolaryngoesophagectomy had been performed to remove a malignant tumor, a shunt was created between the elevated gastric tube and the trachea for vocal rehabilitation in two patients. By covering the tracheostoma, the patients were able to produce a substituted voice without any reflux. However, strange vibrations of the gastric tube slightly disturbed the intelligibility of the shunt voice.

Carcinoma, Squamous Cell↗
PubMed1984

The importance of early treatment of myocardial infarction and approaches for shortening delays in securing medical care.

The present study was conducted on 597 patients with acute myocardial infarction (AMI) who were treated at the coronary care unit (CCU) of Asahikawa Municipal Hospital from January, 1971 to December, 1982. Among 202 patients who were hospitalized within 2 hours after the onset of AMI, 27 (13.4%) developed primary ventricular fibrillation (PVf), 14 patients before hospitalization. Of these 27 patients, 25 (92.6%) were successfully resuscitated and 12 (44.4%) were discharged alive. On the other hand, of 43 patients who were seen within 15 min after the onset of AMI, 11 (25.6%) were diagnosed as having PVf. We divided a series of 365 AMI patients who were seen from 1971 to 1980 into two groups: one group consisted of 178 patients seen within 6 hours after the onset of symptoms, and the other group of 187 patients seen after 6 hours after the onset. The incidence of heart failure with Killip's class 2,3 and 4 was less in the former group than the latter (p less than 0.01). Delays in providing prompt medical treatment appear to be due to the physicians' delayed response, transportation facilities as well as the patients themselves. Public education should help considerably in reducing the time period between the occurrence of symptoms and better medical care.

Coronary Care Units↗
PubMed1984

Clinical efficacy of niludipine in the treatment of angina pectoris.

Some Ca2+-antagonists are used for the treatment of angina pectoris. In the present study niludipine (Bay a 7168) was assessed in various types of angina pectoris cases. Niludipine, a Ca2+-antagonist of the dihydropyridine derivatives, was administered to 50 patients, 27 with effort angina pectoris, 4 with rest angina, 7 with effort plus rest angina, 4 with variant angina, 8 with angina following myocardial infarction in the doses of 60 mg/day or 120 mg/day for 4 weeks and the changes of subjective symptoms and objective findings were evaluated. Improvement was found by 69.6% for effort angina, by 75% (3/4) for rest angina, and side effects by 6% but mild degree--no facial flash, headache, hypotension were observed. The results suggest that niludipine is a safe antianginal Ca2+-antagonist with broad effectiveness for various types of angina pectoris.

Adult↗
PubMed1983

[The peripheral monocytic effect in patients with cervical carcinoma following radio- and immunopotentiation therapy].

Activation of the monocyte-macrophage system is the principal mechanism underlying host defense, immune response with lymphocytic interaction and defence against spontaneous arising tumors. In view of these fact, we investigated effects of radio- and immunopotentiation therapy (OK432) on the following processes in patients of stage III and IV cervical carcinoma. 1) Number of Monocytes determined by Naphthyl Butyrate Esterase and Wright staining. 2) The rate of glucose utilization assessed by Conray-Ficoll density gradient separation. Comparison was made among patients all received radiotherapies with and without subsequent immunopotentiation therapy. In healthy female individuals, the number of peripheral monocytes determined by esterase staining was 338.5 +/- 52.6/microliters. Thus, immunopotentiation recovered the monocyte count, as long as the dose of OK432 was less than 8KE (679.3 +/- 78.5/microliters) (p less than 0.05). The difference was also found in the glucose utilization by monocytes in radiotherapies, the utilization rate was small (98.2 +/- 1.3%), whereas it was much greater in immunopotentiation therapy (82.6 +/- 3.2%). These collectively indicate that the immunopotentiation therapy by OK432 results in non-specific activation of macrophage which will be evaluated as an indicator of cancer immunotherapy and will be also effective for the combined cytoreductive immunotherapies.

Biological Products↗
PubMed1982

[Evaluation of postoperative long-term chemotherapy using FT-207 for the stage III stomach cancer].

The effect of postoperative adjuvant chemotherapy on survival rate of gastric cancer patients of Stage III was evaluated. Ninety-nine patients evaluated as Stage III according to the general rules for surgical studies on cancer of the stomach received surgical treatments at our Department in the period of 1967 to 1978. Patients were classified into following three groups: (A) no chemotherapy group (54 cases) (B) short term chemotherapy group (15 cases, receiving chemotherapy postoperatively for 20 days) (C) long term chemotherapy group (30 cases, more than 3 months postoperatively and more than 60 g of total dose of FT-207) Three-year survival rates of the patients were 40.7% in (A) group, 26.7% in (B) and 66.7% in (C), respectively. These results suggested that a long term postoperative chemotherapy significantly prolonged the survival times of gastric cancer patients in Stage III (C vs B: P less than 0.02, C vs A: P less than 0.03). On the other hand, a short term chemotherapy after surgery decreased the survival rate when comparing with no chemotherapy group, possibly due to impairment of host's anticancer immunity.

Drug Administration Schedule↗
PubMed1982

[Cross-sectional echocardiographic visualization of the infarcted site in myocardial infarction: correlation with electrocardiographic and coronary angiographic findings].

Three dimensional assessment of the site of myocardial infarct was performed using cross-sectional echocardiography in 68 patients with old myocardial infarction. Patients with a history or electrocardiographic findings suggestive of double or multiple infarctions were excluded from the study. In patients with abnormal Q waves in V1 to V3, a regional wall motion abnormality (asynergy) was observed in the anterior portion of the interventricular septum (IVS) and the anterior free wall of the left ventricle (LV) which was extended from the base to apex. Most of them had a significant stenosis in the left anterior descending artery (LAD) distal to the first diagonal branch. Patients with Q waves in V1 to V5 or V6 showed extensive asynergy in the anterior IVS, anterior and lateral free walls of the LV extended from the base to apex. LAD stenosis proximal to the first diagonal branch seemed to be the corresponding coronary lesion. In patients with Q waves in V3 to V5 or V6, asynergy was limited to the apical half of the anterior wall of the LV. In patients with Q waves in II, III and a VF, asynergy was observed in the basal half of the posterior wall and the posterior portion of the IVS.

Coronary Angiography↗
PubMed1980

A case of the Kugelberg-Welander syndrome complicated with cardiac lesions.

There have been a few reports of cardiac involvement in the Kugelberg-Welander syndrome. We presented a case of this syndrome complicated with cardiomegaly and conduction disturbance. The patient, a 21-year-old woman, had atrial standstill and A-V junctional rhythm. The chest X-ray film showed marked cardiomegaly. The His bundle electrogram revealed that H-V interval was 40 msec. She was treated with implantation of cardiac pacemaker.

Adult↗