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Biomedical subjects

J Sheskin

Publications and source records attributed to J Sheskin.

At least 37 records · Page 2Linked to original sources
PubMed1975

[World survey on the use of thalidomide in leprosy reaction].

Review of the answers of a questionary sent to 62 different Leprosy Departments. The results indicate that in 99% of lepromatous patients with lepra-reactions, the response to thalidomide was satisfactory. In the tuberculoid and borderline types of lepra, the results were not good.

Drug Evaluation↗
PubMed1970

Therapy of leprosy.

The latest developments and ideas in the therapy of leprosy are discussed, the need for long-term studies being stressed. The therapeutic efficacy and effective dosages of some sulfones (especially diaphenylsulfone), thiambutosine and long-acting sulfonamides such as sulfamethoxine and sulfalene, are considered. The possibilities for two newer drugs, 4,4'-diacetyldiaminodiphenylsulfone and clofazimine (B-663), both still in the early stages of evaluation, are also described and the potential value of thalidomide in treatment of the lepra reaction is discussed. The authors make a number of recommendations for controlled trials and lines of investigation and, in particular, favour a biochemical approach to the correction of defective host defences. Diaphenylsulfone is still considered the drug of choice for use in the therapy of leprosy.

Aniline Compounds↗