Analysis of urban-rural population dynamics for China.
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Asia↗
Biomedical subjects
J Shen
Publications and source records attributed to J Shen.
[Effects of verapamil on prostacyclin, thromboxane and pancreatic blood flow of rats with experimental acute pancreatitis].
We studied the effects of the calcium channel blocker, verapamil on experimental acute pancreatitis (AP) in rats. The pancreatic blood flow (PBF) and pancreatic tissue perfusion (PTP) were measured after induction of AP. At the same time, the plasma levels of TXB2 and 6-keto-PGF1 alpha were determined by radioimmunoassay. The survival rate and the mean survival time after induction of AP were determined and the pancreatic histology was examined by light and electron microscopy. The results demonstrated a significant early fall in PBF and PTP, a marked increase in TXB2 levels and a slight increase in 6-keto-PGF1 alpha after induction of AP. Treatment with 0.1 mg/100 g verapamil significantly increased PBF and PTP, and decreased TXB2, resulting in a normalization of TXB2/6-keto-PGF1 alpha ratio. The treated animals also exhibited significant increase in the survival rate and the survival time. They also showed decrease in the severity of pancreatic hemorrhage and necrosis, and in the damage to the cellular ultrastructures. These data suggest that calcium blockade increases PBF and PTP, limits the prostanoid imbalance in the early phase of AP, and may influence the development of experimental acute pancreatitis in rats.
6-Ketoprostaglandin F1 alpha↗
[Clinical value of the Chengdu classification of non-Hodgkin's lymphomas].
Two hundred forty-nine cases of non-Hodgkin's lymphomas (NHL) were reviewed by using the working classification of NHL (Chengdu, 1985). The results showed that the patients of 249 cases of NHL ranging in age from 5 to 76 years, with the mean age of 42 of the types were separated into three major prognostic groupings as follows: 1. low (41 of 249 cases, small lymphocytic 27 cases, lymphoplasmacytoid 2 cases, follicular cleaved 7 cases, follicular cleaved and noncleaved 5 cases); 2. intermediate (58 of 249 cases, diffuse cleaved 28 cases, diffuse cleaved and noncleaved 27 cases, follicular noncleaved 3 cases); and 3. high grade malignancy (150 of 249 cases, diffuse noncleaved 49 cases, lymphoblastic 41 cases, immunoblastic 13 cases, polymorphic 39 cases, clear cell 2 cases, histiocytic 6 cases). Each group was significantly different from the others (P less than 0.05). The prognosis of patients with angioimmunoblastic lymphadenopathy like T-cell lymphoma (9 of 249 cases) was not more significant (P greater than 0.05) than that of patients with other polymorphic lymphoma (30 of 249 cases). The results showed this Chengdu classification of NHL is good for practice and usage in clinical evaluation and routine surgical pathology.
Adolescent↗
[Colo-rectal cancer in the elderly].
From September 1981 to December 1988, fiberoptic colonoscopy was performed in 4595 subjects, among whom 476 colorectal cancers were found. Among 692 subjects with ages beyond sixty, 164 (23.7%) colo-rectal cancers were discovered. This study shows that the median age of colo-rectal cancer has increased by 7 years from 45 of the 1950s to the 1970s. The incidence of cancer of the ascending colon is higher (8.5%) in subjects older than 60. It should be noted that 124 out of 164 (75.6%) patients had been misdiagnosed. With prolonging life expectancy in the Chinese population, we strongly advise fibercolonoscopy for the early detection of colo-rectal cancer in the elderly.
Adult↗
Immunoglobulin G subclass deficiency in children with recurrent respiratory tract infections.
With monoclonal antibodies serum immunoglobulin G(IgG) subclasses were measured in seventy children aged 2 to 13 years with recurrent respiratory tract infections including upper respiratory tract infections, otitis media, sinusitis, asthmatic bronchitis and pneumonia. 211 healthy, aged-matched children served as control. IgG subclass deficiency was found in 19 out of the 70 patients (27.1%, single IgG1 deficiency in 7, IgG2 deficiency in 4, combined IgG1-IgG3 deficiency in 5, IgG1-IgG2-IgG3-IgG4 deficiency, IgG1-IgG2-IgG4 deficiency and IgG2-IgG4 deficiency each in 1). The incidence of IgG subclass deficiencies was in the sequence as follows: IgG1, 20%; IgG2, 10%; IgG3, 8.6% and IgG4, 4.3%. The results suggest that IgG subclass deficiency indicate a common disorder in children with recurrent respiratory tract infections.
Adolescent↗
[An application of His bundle electrogram to locate fossa ovalis during percutaneous transseptal balloon valvuloplasty].
A new technique to locate the point of atrial septal puncture, i.e. His bundle electrogram locating method (HBELM), was reported. By using this HBELM, the successful rate of atrial septal puncture was 100% in 21 cases of mitral stenosis during percutaneous transseptal balloon valvuloplasty and in 5 cases of them, the puncture needle got into left atrium smoothly through patent fossa ovalis at the position determined by HBELM without making puncture. As well known, the point of atrial septal puncture is fossa ovalis. According to the anatomy, His bundle is located at the same horizontal line as fossa ovalis. After HBE being recorded, a horizontal line is drawn from the point of His bundle catheter electrode. The authors suggest that the intersect of this line with right border of thoracic vertebra should be the point of atrial septal puncture. The above study showed that HBELM for atrial septal puncture is a correct and easy method and may be better than other methods used before.
Adult↗
[The relationship between protection of regenerating rat liver against carbon tetrachloride and change of its mitochondrial respiratory activity].
Protection of regenerating rat liver against carbon tetrachloride (CCl4) poisoning 96 h after partial hepatectomy was observed, and the respiratory activity of its mitochondria was determined by using oxygen electrode method. The results were as follows: (1) Mortality in partial hepatectomized rats (PHR) caused by CCl4 (50%, 10 ml/kg) was reduced significantly as compared with sham operated rats. (2) Following hepatic damage induced by CCl4 (50%, 5 ml/kg), the levels of serum bilirubin and sGPT in PHR were significantly lower than those in sham operated rats. Histological examination of the liver also showed a significant extent of repair. (3) Respiratory activity of regenerating liver mitochondria in PHR with or without CCl4 poisoning was higher than that in sham operated rats, and the respiratory activity went parallel with the degree of repair of histological damage, the reduction of serum bilirubin, sGPT and mortality. The results mentioned above indicate that increase of respiratory activity of regenerating liver mitochondria and resistance to CCl4 may play an important role in the protection of regenerating liver against CCl4.
Animals↗
Beta-blockers for cocaine-induced coronary vasoconstriction.
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Adrenergic beta-Antagonists↗
Relaxed-lattice model of isolated and paired isoelectronic traps in GaP.
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Journal Article↗
Dose-dependent emergence of preneoplastic foci in rat livers after exposure to 2-nitropropane.
Male and female Sprague-Dawley rats, 4-6 days old were exposed for 3 weeks (6 h/day, 5 days/week) to 2-nitropropane vapours of 0, 25, 40, 50, 80 and 125 ppm. One week later polychlorinated biphenyls (Clophen A50, 10 mg/kg body weight) were administered for promotion twice a week for 8 weeks. Thirteen weeks after starting the experiments the logarithms of the numbers of preneoplastic liver foci deficient in adenosine-5'-triphosphatase were found to be linearly related to the exposure concentrations of 2-nitropropane. Male rats exhibited an approximately four times lower foci incidence than females.
Adenosine Triphosphatases↗
Study of normal and cancerous urine using photoacoustic spectroscopy.
Photoacoustic spectroscopy (PAS) is a valuable technique, increasingly applied in clinical and biological analysis. Light absorption properties of urine and body tissue can be obtained more easily by the PAS technique because of its high sensitivity, than by the conventional optical techniques. By observing their absorption properties it is possible to diagnose some diseases and in this study we have used PAS to assess cancerous changes in urine and tissue. Three groups were studied: normal individuals; patients with cancer; and patients with cancer and subsequent inflammation; and the characteristic light absorption peaks obtained for a certain band (240-420 nm). These results were compared with the clinical diagnosis and proved consistent and reliable for the diagnosis of urinary tract cancer subsequently confirmed by operation. This method will probably be a useful tool for the early clinical diagnosis of cancer of the urinary system.
Diagnosis, Computer-Assisted↗
Immunoglobulin G subclasses in serum and circulating immune complexes in patients with Kawasaki syndrome.
IgG subclass concentrations in sera of 17 patients with Kawasaki syndrome were determined. Significantly increased IgG1 (P less than 0.001) and IgG3 (P less than 0.001) were found in the patients compared with 22 age-matched healthy children, whereas IgG2 and IgG4 were normal or slightly decreased. IgG immune complexes were measured by protein A-enzyme-linked immunosorbent assay (ELISA) combined polyethylene glycol precipitations. Eight of 17 patients (47.1%) were found to have circulating immune complexes (CIC) values above the normal control range (geometric mean +2 SD). IgG subclass composition in CIC was analyzed. The subclasses in CIC were predominantly IgG1 and IgG3. Because the antibody responses to different antigens exhibit IgG subclass restriction, it would suggest that the change of serum and CIC IgG subclasses in Kawasaki syndrome may have relevance to the pathogenesis of the disease.
Antigen-Antibody Complex↗
Hemodynamic changes during acute pancreatitis and the dopamine therapy.
A dog model was used to measure the hemodynamic changes in acute pancreatitis (AP) caused by intraductal injection of fresh trypsin-bile mixture and to investigate the efficacy of dopamine in the treatment of AP. Dopamine was administered intravenously for 3 hours at a dose of 0.6 mg/kg/hour starting 10 min after the induction of AP. Hemorrhagic pancreatitis was characterized by a fall in cardiac output (CO), systemic arterial pressure (SAP), an increase in pulmonary vascular resistance (PVR), systemic vascular resistance (SVR) and the development of early reduction of pancreatic blood flow (PBF). Administration of dopamine produced a significant increase in PBF and leads to a normalization in CO, SAP, PVR and SVR. In addition, dopamine significantly reduced the severity of the AP, as assessed by histological staging and mortality rate. These results suggest that dopamine can limit the progression from edematous to hemorrhagic pancreatitis and prevent irreversible pancreatic damage through preserving PBF at the early phase of AP.
Acute Disease↗
[Von Willebrand factor in acute leukemia].
Using Laurell's rocket and crossed immunoelectrophoresis, we studied the function of vWF on the basis of its quantity and quality. The ristocetin-induced platelet aggregation was also investigated. The results revealed that the level of plasma vWF:Ag in acute leukemia (88.53 +/- 46.33%) was significantly higher than that in normal controls (90.53 +/- 29.54%) (P less than 0.01) and markedly decreased as these cases were in partial or complete remission (105.29 +/- 26.65%) (P less than 0.01), but there were no significant differences between the cases with (204.76 +/- 68.17%) and those without bleeding tendency (174.77 +/- 65.78%), nor between ALL (185.22 +/- 62.19%) and ANLL (192.43 +/- 77.97%) (P greater than 0.05). Compared with normal controls, crossed immunoelectrophoresis of plasma vWF in 21 cases showed a rapid migration of the precipitin arcs toward the positive pole in 16 cases. This indicates that there is a relatively increased amount of small multimers in the plasma, which do not have the active function of vWF so that the ristocetin-induced aggregation was reduced or even absent in those 21 cases (the maximum aggregation rate was 62.89 +/- 34.02% in the patients and 104.69 +/- 12.13% in normal controls (P less than 0.01). The possible mechanism and clinical significance of these changes are discussed.
Adolescent↗
[Subacute brainstem hematoma. A surgically treated case].
We report a case of pontine haemorrhage in which symptoms and signs developed over a 2-months period. Surgery was successful but the patient subsequently died. The pathophysiology of subacute and chronic symptoms and signs is discussed.
Adult↗
[Current status of the study of mechanisms of liver injury caused by some commonly used hepatotoxic agents].
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Acetaminophen↗
[New pharmaceutical action of indomethacin].
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Animals↗
[The effects of pulsatile pumping on tissue perfusion and renal function during deep hypothermic low flow perfusion].
The effects of pulsatile pumping on tissue perfusion and renal function during deep hypothermic low flow perfusion were compared with non-pulsatile pumping. Twelve dogs were classified into 2 groups by the perfusion technique used. Animals were core cooled to 20 degrees C esophageal temperature with 80 ml/kg/min perfusion rate and maintained at the level for 2 hours with low flow perfusion (LFP) (30 ml/kg/min), then rewarmed to 35 degrees C with 80 ml/kg/min flow rate. As compared with the non-pulsatile group, pulsatile group demonstrated greater urine output during rewarming (p less than 0.05) and greater lymph flow during core cooling (p less than 0.05). The non-pulsatile group showed higher lymph/plasma protein concentration ratio (Lc/Pc) during LFP and rewarming (p less than 0.05), and greater plasma protein clearance during rewarming (p less than 0.05), and much higher increase of interstitial fluid pressure. The lesser water retention during bypass was also noted in the pulsatile group (28.6 +/- 27.6 ml/kg vs 85.4 +/- 52.1 ml/kg, p less than 0.05). These findings have suggested that the pulsatile perfusion may be useful for the infant cardiopulmonary bypass reducing tissue edema and preserving better renal function.
Animals↗