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Biomedical subjects

J Serup

Publications and source records attributed to J Serup.

At least 127 records · Page 7Linked to original sources
PubMed1985

Dry hands in scleroderma. Including studies of sweat gland function in healthy individuals.

Complaints of dry hands were evaluated in 68 patients with generalized scleroderma (GS) and 66 healthy individuals (HI) for comparison. Studies included evaporimetry of the hands and forearms as performed under physiological conditions indicating sweat gland function. Complaints of dry hands were more frequent (p less than 0.001) in GS (71%) than in HI (32%) as was the use of emollients (68% and 32% respectively). Evaporimetry at eight different locations (flexor and extensor aspects of middle phalanx, proximal phalanx, hand and forearm) showed decreased evaporation (p less than 0.01 and p less than 0.001) in GS. However, there was no difference in evaporation between patients complaining of dry hands and patients without complaints. In a few locations the evaporation was negatively correlated (r from -0.287 to -0.376, p less than 0.05 and p less than 0.01) to the duration of GS and positively correlated to parameters of cutaneous thickening (ultrasound measurement skin thickness r = 0.252, p less than 0.05; ring size r = 0.294, p less than 0.05). In the group of healthy individuals complaints of dryness was more frequent (p less than 0.05) in females (39%) than in males (7%), and females also used emollients more frequently (p less than 0.01). HI complaining of dryness had similar evaporation as HI with no complaints. Physiological evaporation was negatively correlated to age, in particular in the palm and volar side of fingers (r from -0.424 to -0.454, p less than 0.01 and p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

The clinical value of morphological rating of human spermatozoa.

The clinical fertility of 1,077 men whose semen had been analyzed between 1950 and 1952, in terms of types of abnormal spermatozoa morphology according to the Hammen system with 14 types, was studied 20 years later by means of a questionnaire (785 replies i.e., 72.9%). There was a significant difference (P less than or equal to 0.01) between couples who obtained living children and the couples who did not, expressed as the mean percentages of spermatozoa with narrow heads, round heads, amorphous heads, irregular heads, abortive forms, double forms, staining abnormalities and vacuoles. The same tendency was found for piriform heads, small heads, belted heads and various rare heads. Giant head showed no difference, and pinhead was not represented. Piriform heads and narrow heads increased significantly more than the other types (P less than or equal to 0.01) with increasing total number of abnormal spermatozoa. There was no relation between any abnormal type and abortions and otherwise abnormal pregnancies. Detection of types of abnormal spermatozoa morphology does not seem to improve semen analysis in terms of predicting chance of pregnancy, and we prefer to use the percentage of morphologically normal spermatozoa, the inverse expression of abnormal spermatozoal morphology as a total, for routine semen analysis.

Abortion, Spontaneous↗
PubMed1985

Punch biopsy of the skin by electric power drill: effect of speed. A post-mortem study.

The effect of drill speed on biopsy size and quality for microscopy was studied postmortem. Four millimeter punch biopsies were taken from the abdominal skin by different techniques: Manual punch and drill (250, 600, 1,200, 4,000, 18,000, 36,000 rpm). Biopsies taken with 250, 600 and 1,200 rpm were not different in quality from biopsies taken with manual punch. Biopsies taken at 4,000 rpm exhibited microscopic signs of trauma and those taken at 18,000 and 36,000 rpm were much poorer in quality and severely damaged. In conclusion, a high speed drill cannot be recommended for biopsy of the skin.

Abdominal Muscles↗
PubMed1985

Increased central cornea thickness in localized scleroderma (morphoea).

The central cornea thickness (CCT) was measured in 17 patients with localized scleroderma (morphoea) by the Haag-Streit pachymeter. Results were compared with measurements in healthy persons matched with respect to sex and age. CCT was increased (p 0.01) in patients with morphoea (mean 0.535 mm, range 0.510-0.580, SD 0.0217) as compared to the controls (mean 0.511 mm, range 0.490-0.525, SD 0.0094). In 9 (53%) of the patients CCT was more than mean + 2 SD in the controls. CCT was correlated to the duration of morphoea (correlation coefficient 0.660, p 0.01). It is discussed that the increase in cornea thickness may be a sign of minimum cornea "swelling" with alterations of the glycosaminoglycans of the corneal stroma as a possible background. The study demonstrates that morphoea is not simply a local disease confined to the plaques of the skin.

Adolescent↗
PubMed1985

Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo.

Five corticosteroid ointments and placebo were compared in 17 volunteers with regard to their influence on normal skin under occlusive conditions. Each volunteer had six simultaneous applications on the forearms and six on the back. The trial was double-blind and lasted 4 weeks. The ointments were placed in randomized order. The treatments were 0.1 and 0.03% domoprednate, 0.1% hydrocortisone butyrate, 0.1% betamethasone valerate, 0.05% clobetasole propionate and placebo. Skin thickness was measured on days 0, 7, 14, 21 and 28, transepidermal water loss on days 0, 14 and 28, while blood flow and telangiectasias were evaluated only on day 28 at termination of the trial. The skin thickness became significantly reduced on all corticosteroids, but not on placebo; 0.03% domoprednate, however, tended to have an intermediate position between placebo and the other ointments. The transepidermal water loss did not change. Rating of telangiectasia under stereomicroscope showed a significantly lower score after 0.03% domoprednate and placebo as compared to the other ointments. Assessment of telangiectasia by laser-Doppler flowmetry showed a similar tendency. It is concluded that 0.1% domoprednate is comparable to other topical corticosteroids with respect to atrophogeneity and formation of telangiectasia, but the 0.03% concentration seems to result in fewer side effects.

Administration, Topical↗
PubMed1984

Blood flow of morphoea plaques as measured by laser-Doppler flowmetry.

Blood flow measurements by laser-Doppler flowmetry were performed on 15 patients with localized scleroderma (morphoea). Thirty morphoea plaques were studied by means of measurements of the sclerotic centre, the perilesional area, and regional control of the normal-appearing skin of the individual patients. Blood flow was increased (P less than 0.01) in the sclerotic area of all patient material and in the 10 patients having one or a few plaques (P less than 0.01). Five patients with generalized morphoea showed the same tendency. Blood flow was also increased in the perilesional area (P less than 0.01) of the total material, and in the patients with one or a few plaques (P less than 0.05), particularly in the case of a 'lilac ring'. 133Xenon washout measurements in 3 patients showed parallel results. The blood flow of plaques with clinically 'advanced' scleroderma was higher (P less than 0.01) as compared to plaques with 'slight' scleroderma. Measurements in pigmented spots after previous morphoea showed normal blood flow.

Adolescent↗