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Biomedical subjects

J Seignalet

Publications and source records attributed to J Seignalet.

At least 73 records · Page 4Linked to original sources
PubMed1975

[Value of HL-A groups in diagnosis in rheumatology].

Since 1972, several relations have been demonstrated between some HL-A antigens and some articular diseases. The W27 antigen frequency is highly increased in ankylosing spondylitis (88%) and in Reiter disease (78%) compared with controls (5%). In peripheral forms of psoriatic rheumatism, the W17 and HL-A13 antigens are more frequent (24% and 15%) than in healthy subjects (4% and 5%). In central forms of psoriatic rheumatism, there is a relation with W27 (48%) and still, we do not know if this association concerns only spondylitis or also sacro-iletis. The HL-A typing may be useful for the diagnosis of some rheumatologic diseases, when for the diagnosis of ankylosing spondylitis. The relation between W27 and ankylosing spondylitis is cleanly stronger than that between Waaler-Rose reaction and rheumatoid arthritis.

Alleles↗
PubMed1975

[Etiology of Paget's disease of bone].

The etiology of Paget's disease is just as doubtful in 1975 as it was in 1876 when Sir James Paget described the disease. The authors analyse the etiology on the basis of 100 personal cases and the literature. Although there are undoubtedly familial cases of the disease, investigation of the leucocyte grouping of 46 patients with Paget's disease did not reveal any correlation between occurrence of the disease and the HL-A antigens. Various pathological associations have been reported in the literature and were also found in this series. These associations were at the limits of coincidence (inflammatory rheumatism, diffuse chondrocalcinosis, multiple myeloma...). Metabolic changes (hyperuricaemia, hyperglycaemia, dyslipidaemia) did not appear to be more frequent than in control patients. Involvement of elastic tissue and the presence of pseudocrystalline inclusions in the osteoclasts constitute interesting points for discussion.

Adult↗