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Biomedical subjects

J Seifert

Publications and source records attributed to J Seifert.

At least 217 records · Page 12Linked to original sources
PubMed1975

[Immunologic studies in patients with clinical human albumin incompatibility].

17 cases of clinical incompatibility reactions due to human serum albumin were examined. The reactions consisted of tachycardia, fever, exanthema and hypotension. Regarding the onset of time, "early" and "late" reactions were distinguished. Pollution of the administered albumin batches as etiologic factor was excluded. The results of immunodiffusion, antigen elimination and skin tests suggest a pathogenetic influence of immunological reactions. The application of further purified albumin solutions might reduce the frequency of incompatibility reactions.

Adult↗
PubMed1975

[Ductus thoracicus drainage in man. Changes of the lymph cells and protein fractions].

1. During thoracic duct drainage a significant decrease of serum beta- and gammaglobulins can be found. 2. The withdrawn lymphprotein can be sufficiently substituted by human serum albumin. 3. The number of small lymphocytes decreases significantly during thoracic duct drainage, while the number of large lymphocytes and lymphoid cells increases. 4. The drainage of thoracic duct in humans is a highly immuno-suppressive procedure without major risks.

Amyotrophic Lateral Sclerosis↗
PubMed1975

[Blood picture changes following single and prolonged oral application of ALG in the dog].

Mongrel dogs were orally treated with 20 mg/kg ALG or NHG respectively. A significant decrease of the peripheral lymphocyte count was observed not only during 6 hours after the application of ALG but also during longtime observation. This lymphocytopenia was found to be between 30% and 50%. The effect of ALG after oral administration is smaller than after i. v. application. All other blood cells remained essentially unaffected by ALG as well as NHG. Whereas the efficacy of i. v. applied ALG is reduced by antibody formation, this cannot be expected to the same degree during oral administration, because the antibody formation is markedly reduced by the oral route of application.

Administration, Oral↗
PubMed1975

[Hydroxyethyl starch as plasma substitute: experiments in isovolamic haemodilution (author's transl)].

Isovolaemic haemodilution to a hematocrit of 10% was achieved by stepwise exchange of blood against 6% hydroxyethyl starch (HES) in 11 splenectomized dogs. All animals survived the actuely performed extreme haemodilution; one animal died 5 days later due to massive bilateral pneumonia. Blood volume as determined by 51Cr-tagged red cells was unchanged at hematocrit 10%; 2 and 5 hours after reaching the minimum haematocrit, blood volume was reduced by 7 and 15% of control. At day 3 after dilution, blood volume was normal again. Thus under conditions of extreme isovolaemic haemodilution the volume effect of hydroxyethyl starch was found inferior to that of dextran 60. Haemodilution with HES was associated with a presistent augmentation of the serum concentration alpha-amylase.

Amylases↗