Biomedical subjects

J Seelen

Publications and source records attributed to J Seelen.

14 recordsLinked to original sources

PubMed2005

A multicentre evaluation of the Medtronic AVE Flexible Iliac Bridge Stent in the iliac arteries (the first study).

PURPOSE: To investigate the short term and 6 month outcomes of a recently introduced iliac stent (the Medtronic AVE Flexible Iliac Bridge Stent). METHOD: One hundred and sixteen patients, 122 limbs from 6 European sites with atherosclerotic occlusive disease were included if they either had a full occlusion or there was a residual gradient >10 mmHg following PTA. Clinical, haemodynamic and Duplex outcomes were recorded to 6 months. RESULTS: After stent placement there was no residual stenosis >30 and 8.1% of segments had a residual resting gradient of >10 mmHg. There were three local complications and three deaths at 30 days. Primary patency at 30 days and 6 months was 94.1 and 82.7%. Marked clinical improvement occurred in 87.6 and 86.2% at 30 days and 6 months. CONCLUSION: The Medtronic AVE iliac stent has good 30 day and 6 months outcomes supporting the effective use of this device in occlusive disease.

Adult↗

PubMed2000

Progression of atherosclerosis at one-year follow-up seen with volumetric intravascular ultrasound in femoropopliteal arteries.

Volume measurements derived from intravascular ultrasound (IVUS) images assessed with an automated contour analysis system are accurate and reproducible. However, it is unknown to what extent plaque volume may change at follow-up. Therefore, the purpose of this longitudinal study is to examine whether IVUS is a sensitive means to identify progression of atherosclerosis and its derived primary end point plaque volume at 1-year follow-up. Patients (n = 11) undergoing percutaneous transluminal angioplasty (PTA) of the femoropopliteal artery were studied with IVUS immediately after PTA in the same session and at 1-year follow-up. Matched, well-identified vascular segments (3 to 4 cm in length), not subjected to PTA, imaged at baseline and after 1-year follow-up, were used for calculation of the longitudinal change in lumen, vessel and plaque volume, and mean plaque thickness. The median length of the selected vascular segments was 4 cm. At follow-up (12+/-2 months) a nonsignificant increase in lumen volume (2.3+/-11%), vessel volume (2.0+/-7.0%), and plaque volume (3.0+/-5.1%) was seen; the mean plaque thickness increase was 2.2+/-5.6%. In conclusion, progression of atherosclerosis implies changes in plaque and vessel volume, resulting in lumen volume change. This observation has important implications for future clinical trials aimed at monitoring the effect of pharmacologic agents on the progression and/or regression of atherosclerosis.

Adult↗

PubMed2000

Reproducibility of volumetric quantification in intravascular ultrasound images.

The reproducibility of volume measurements in intravascular ultrasound (IVUS) images derived from separate pull-back manoeuvres remains to be elucidated. Patients (n = 23) were imaged with IVUS prior to (first series) and following percutaneous transluminal angioplasty (PTA) (second series). In 15 patients, one matched vascular segment (3-4 cm in length), not subjected to PTA, was used for analysis of lumen, vessel and plaque volume using an automated contour analysis system. Volume measurements assessed by two independent observers and in the two separate series were compared. Interobserver differences in volume measurements were small (< or =0.4%), with low coefficients of variation (< or =1.7%) and high correlation coefficients (r = 1.00). Differences in volume measurements obtained in the two separate series were small (< or =2.6%), with low coefficients of variation (< or = 8.6%) and high correlation coefficients (r = 0.97-0.99). In conclusion, volume measurements derived from IVUS images are highly reproducible. Therefore, IVUS may be used to monitor the progression/regression of atherosclerotic plaque volume in a longitudinal study.

Aged↗

PubMed1995