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Biomedical subjects

J Searle

Publications and source records attributed to J Searle.

75 records · Page 5Linked to original sources

Deviation of the path of a sliding object due to road camber.

After a road accident, slide marks are sometimes seen to exhibit a slight curvature, which is often due to road camber. The lateral deviation from that cause is shown to be the length of the slide multiplied by the lateral gradient and divided by twice the friction coefficient.

Accidents, Traffic↗

Neonatal diabetes mellitus associated with severe diarrhea, hyperimmunoglobulin E syndrome, and absence of islets of Langerhans.

Neonatal insulin-dependent diabetes mellitus (DM) is very rare and descriptions of the pancreatic pathology in affected infants vary considerably. Death after 10 months of a male child who suffered the onset of insulin-dependent DM as a neonate, together with severe diarrhea and features of the hyperimmunoglobulin E syndrome, was found to be associated with absence of islets of Langerhans. There was no evidence of any pancreatic exocrine abnormality or other endocrinopathy. Two male relatives with insulin-dependent DM have also died as infants, and after review of the literature it is suggested that this disease process may be part of the spectrum of an X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy. Evidence is presented to support the suggestion that this syndrome is an autoimmune disorder.

Diabetes Mellitus, Type 1↗