RNA editing: a novel mechanism for the regulation of dietary cholesterol absorption.
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Biomedical subjects
Publications and source records attributed to J Scott.
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Nineteen arteriovenous fistulas of the external carotid branches in 17 patients were treated by a variety of percutaneous transvascular techniques. There were nine females and eight males; 11 fistulas were traumatic in origin, five were "spontaneous," and three were thought to be congenital. The most frequent presenting symptoms were a bruit and thrill, followed by pulsatile tinnitus, pulsatile mass, headaches, and ocular problems. The symptoms were related to fistula site and venous drainage. The middle meningeal artery was involved most often, followed by the superficial temporal, occipital, internal maxillary, and ascending pharyngeal arteries. All patients except one were successfully cured, including one recurrence. There were no complications, and the hospital stay averaged 3 days.
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Each year approximately 3,200 volunteer patients attend the examinations of the Royal College of Physicians in England and Wales. A confidential postal questionnaire concerning patients' experiences and satisfaction was administered to those attending North Tees General Hospital in June 1992 with a 90% response rate. The majority of patients derive some enjoyment from the experience and do not mind being repeatedly examined, some even up to eight times per session; but they do feel neglected if examined only once per session. Twenty-two per cent of first time attenders would have liked to have had more information about the proceedings beforehand.
Primary Sjögren's syndrome is a systemic autoimmune exocrinopathy characterized by a lymphoplasmacytic infiltrate and destruction of salivary and lacrimal glandular tissues. There is no widely accepted or effective systemic therapy for this disorder. The purpose of this 6-month randomized, double-blinded, placebo-controlled study was to examine the effects of prednisone (30 mg, alternate days), piroxicam (20 mg, daily), or placebo on the salivary, lacrimal and immunologic alterations of primary Sjögren's syndrome. Eight patients were enrolled in each group. Salivary and lacrimal function were assessed at entry and at the completion of treatment. Labial minor salivary gland tissue was obtained at these times and examined for intensity of infiltration (focus scores) and for the relative proportion of glandular elements. Serologic and subjective evaluations were done as well, and patients were monitored for therapy-related side effects. Neither active treatment led to significant improvement in salivary or lacrimal function, although prednisone improved salivary flow in selected patients and was associated with positive subjective responses. Prednisone also significantly decreased the serum total protein, IgG, IgA, and sedimentation rate and increased the white cell count. There were no significant alterations in either focus scores or the percentage of glandular component tissues of minor glands with either active treatment. This study demonstrated that 6 months of prednisone or piroxicam at the doses utilized failed to improve the histological or functional parameters of salivary and lacrimal glands in primary Sjögren's syndrome.
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