[Frequency distribution of parameters of the human electroretinogram].
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Biomedical subjects
Publications and source records attributed to J Schuster.
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Fifty-three samples of sera from normal subjects and from patients with type IIa, IIb and IV hyperlipoproteinemia were shipped from Hannover to the collaborative laboratories in Vienna and Mannheim, which participated in the quantification of their lipoprotein fractions based on polyanion precipitation of electrophoretically separated lipoproteins followed by densitometric measurement of alpha-, prebeta- and beta-lipoproteins. Total serum cholesterol and cholesterol calculated from quantified lipoprotein fractions were highly correlated, the correlation coefficients ranged between r = 0.93-0.98. Furthermore, we found a high concordance comparing the beta-, and prebeta- and alpha-cholesterol with data obtained from lipoprotein fractionation and subsequent cholesterol measurement by ultracentrifugation. The obtained correlation coefficients were always higher than r = 0.91. High accuracy and reproducibility of the quantitative lipoprotein electrophoresis justify its recommendation for wide use in the field of clinical chemistry.
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In 171 patients with coronary arteriosclerosis the severity of the angiographic findings was assessed by the score of Friesinger. The total serum cholesterol concentration showed an only weak positive correlation with the extent of coronary arteriosclerosis. In contrast, a strict correlation could be documented with the LDL-HDL ratio. The LDL-HDL ratio was 1.49 in the control group with angiographically free coronary arteries, 1.95 in patients with an angiographic score of 1-5, 2.39 at a score of 6-10, and 2.75 at a score of 11-15. The corresponding total serum cholesterol values (control group: 219 mg/100 ml) were 229 mg/100 ml, 242 mg/100 ml and 258 mg/100 ml. Especially at still normal serum cholesterol concentrations an already pathological shift in the lipoprotein pattern in correlation with the extent of coronary arteriosclerosis was indicated by the LDL-HDL ratio. Thus a greater predictive power for coronary risk is attributed to the LDL-HDL ratio rather than to the total serum cholesterol concentration.
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The determining factors of coronary blood supply are described. The dependence of the coronary vascular resistance and the coronary extra-vascular resistance on the oxygen requirement and metabolism products of the heart muscles on one hand, and the various haemodynamic parameters on the other, are delineated. Based on this conception the principles for a therapy of coronary insufficiency are deduced. The difficulties, however, which limit this therapeutic procedure are also mentioned.
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An analysis of the syntactic, semantic and phonological features of a corpus of therapy words drawn form recent publications dealing with remedial language instruction was performed to determine whether these words would in theory support full grammatical acquisition. Percentage of occurrence data were compared with distributional statiscs for adult (Berger, 1967a) and child (Weir, 1962) usage. The results suggested a bias in favor of concrete words referring to everyday objects around the home, nouns, verbs and adjectives, and morphemes of simple syllable and sound structure. In general the words analyzed appeared more suitable for children under 3 years of age than for older children. Of factors guiding the clinician's selection of therapy words, native speaker intuition for distributional characteristics of the language was regarded as the major factor of judgment.
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