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Biomedical subjects

J Schurmans

Publications and source records attributed to J Schurmans.

5 recordsLinked to original sources

Osteoblastoma: clinical and radiologic findings in 98 new cases.

The data on 98 new patients with osteoblastoma were studied. The clinical features of pain, scoliosis, and neurologic deficit were largely consistent with those in previous reports. Osteoblastoma is usually a lytic lesion originating in the medulla of bones with matrix ossification and mild surrounding sclerosis. Osteoblastoma of the spine demonstrated better tumor delineation in the vertebrae, and a bony rim on the soft-tissue side was seen less frequently than previously observed. Osteoblastoma of the talus frequently appears as a blister on the surface of the bone and is accompanied by osteoporosis. In the hands and feet, the radiographic appearance is often very similar to that of aneurysmal bone cyst and giant cell tumor. In the skull it strongly resembles a button sequestrum of bone. The origin and extent of the tumor, the presence of matrix mineralization, and tumor delineation depicted as a thin bony shell are often better appreciated on computed tomographic (CT) scans. In addition, CT can demonstrate both edema and atrophy of the surrounding soft tissues. At magnetic resonance (MR) imaging, osteoblastoma demonstrates signal intensities similar to those of other bone neoplasms. In addition to the advantages offered by CT, MR imaging can help differentiate tumor tissue from accompanying edema.

Adolescent

Complete recovery from hepatitis B and associated hemolysis in a patient with underlying T-cell deficiency.

A 17-yr-old woman presented with acute hepatitis B. She had preexisting well-documented immune deficiency, clinically apparent as chronic mucocutaneous candidiasis, and recurrent severe viral infections. Life-threatening but spontaneously resolving Coombs-negative hemolysis complicated the recovery phase. Complete healing of the hepatitis with disappearance of hepatitis B surface antigen from serum and normal hepatitis B surface antibody and hepatitis B core antibody production occurred in spite of T-cell dysfunction.

Acute Disease

Comparative effects of alinidine and propranolol in ischaemic heart disease.

The effects of single oral doses of alinidine 40 mg, propranolol 40 mg or placebo during a maximal exercise test on a bicycle ergometer in patients with angina pectoris were studied in a randomised, double blind study. 2 and 5 h after drug intake a small fall in resting heart rate and systolic blood pressure was observed both after alinidine and propranolol. At a fixed work load both drugs decreased heart rate, systolic blood pressure, double product and the extent of ST segment depression. Total work performed and time to appearance of angina pectoris were increased 2 h alinidine and propranolol. The same effects were still apparent 5 h after propranolol but not after alinidine. At peak exercise neither drug had any effect on the extent of ischaemic ST segment depression.

Blood Pressure