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Biomedical subjects

J Schulze

Publications and source records attributed to J Schulze.

At least 145 records · Page 8Linked to original sources
PubMed1982

Sports-medical studies on parachute jumpers with particular reference to the behavior of heart rate.

The aim of the experiment was to record the heart rate tracings of three groups of parachutists - with manually operated parachutes, automatically operated parachutes and formation parachutists (sky divers) - during the jump and to compare these with the findings obtained during bicycle ergometer stress tests. A total of 112 parachute jumps involving 31 subjects were evaluated. All the subjects exhibited a significant increase in heart rate during the exit, canopy opening and landing phases. Qualitatively, the heart rate curves of the formation, manual and automatic parachutists showed a similar trend. Rises in heart rate during the opening of the parachute (for the formation parachutists) and during landing (for the automatic parachutists) were, however, particularly pronounced. The increase in heart rate can be principally ascribed to emotional tension and a state of anticipation rather than to physical stress. The comparative evaluation of the ergometer tests showed that as a general rule stress factors in the submaximal region occur during parachuting, but that in extreme situations heart rates in the maximal region of physical stress may well be expected.

Adult↗
PubMed1980

Toxicological effects of steam-sterilized high lactose diets on conventional and gnotobiotic rats.

Gnotobiotic rats fed steam-sterilized high lactose diet during 38 weeks showed a more delayed body weight gain and higher pathological changes in liver, kidneys, adrenal glands, and ovaries than conventional rats under the same conditions. Maillard-products formed by heating of a mixture of carbohydrates and proteins would be deaminated partially by intestinal microflora. Consequently the gnotobiotic and conventional rats may absorb different amounts of Maillard-products. It is possible that this is the reason for the differences between conventional and gnotobiotic rats. Hence these findings should be taken into consideration in food technology especially in heating of foodstuffs for example milk products.

Adrenal Glands↗
PubMed1979

[Vascular complications in primary hyperlipoproteinemias (HLP) with special reference to changes in the eye fundus].

The distribution of the types of hyperlipoproteinaemias revealed 2 peaks of frequency, i. e. in the types IIa and IIb corresponding 41% and in the types IV and V corresponding 55%. Weight indices and disturbed glucose tolerance are in the types III-V significantly higher than in the types IIa and IIb. The risk factor hypertension was registered in 34% in the investigation material. The highest prevalence rates for myocardial infarctions were in the patients of the types IIb and III, for PAD in the type III. The addition of hypertension and diabetes mellitus to hyperlipoproteinaemia reveals an exacerbation of the vascular risk. Changes of the fundus oculi, which correspond to the picture of a fundus hypertonicus cause to think of the presence of a hyperlipoproteinaemia in all patients with normotension.

Aged↗
PubMed1979

Basal and stimulated hyperinsulinemia in obesity: relationship to adipose-cell size.

In 17 non-selected, non-hyperlipoproteinemic subjects without overt diabetes both adipose tissue biopsy and an oral glucose tolerance test (50 g) were performed. All persons were weight-stable at the time of investigation. A significant correlation between fasting insulin concentration and mean adipocyte volume was observed, whereas no correlation existed between ideal body weight index and fasting insulin level. Persons with larger adipocytes had elevated basal insulin levels as well as higher and longer lasting increments following the glucose challenge. They also exhibited significantly higher mean glucose levels during the OGTT. When these patients were matched for glucose tolerance with the subgroup having smaller mean adipocyte volumes, the difference in insulin levels was still demonstrable. This study underlines the importance of adipose-cell enlargement regulating basal and stimulated insulin output.

Adipose Tissue↗
PubMed1978

Influence of diet composition on insulin output, carbohydrate tolerance and lipid values in primary hypertriglyceridemia (HT).

Hypertriglyceridemic patients generally show a post-challenge hyperinsulinemia. In patients where carbohydrate intolerance coexists, increasing of reactive insulin is relatively diminished and delayed. In a group of 31 hypertriglyceridemic patients these characteristics of insulin increments in peripheral blood during a 50 g OGTT were constant: neither a low-fat (carbohydrate-rich) nor a high-fat (low carbohydrate) isocaloric, weight-maintaining diet had a significant influence on this parameter when compared with a standard diet (protein content unaltered throughout all diet periods). Glucose tolerance was significantly improved after the low-fat, high-carbohydrate diet. The results were neither correlated with the type of dietary inducibility of fasting triglyceride levels in individual cases nor with the sequence of diet periods prescribed. Hyperinsulinemia in hypertriglyceridemic patients is not believed to be the direct consequence of abnormal composition of the antecedent diet.

Carbohydrate Metabolism↗
PubMed1976

[Is primary or secondary prevention of diabetes mellitus in hyperliporoteinemia possible under long-term clofibrate therapy?].

The investigations of metabolism explained speak for an improved condition of the carbohydrate metabolism during the first months of the therapy. However, they are not sufficient to prove a preventive effect of clofibrat per se during long-term treatment. Our examinations by means of the glucose infusion test show that on certain defined conditions with intensive general treatment positive effects may be registered, which, however, cannot be reproduced in a large collective during outpatient care. On the contrary, it is to be assumed that the whole therapeutic regime has an influence. Nevertheless, one may establish that the incidence portion of the diabetes manifestation in patients with hyperlipoproteinaemia treated with regadrin corresponds nearly to that one of the average population of Dresden. It is puzzling that the death rate in patients with hyperlipoproteinaemia and diabetic condition of metabolism is significantly higher than in hyperlipoproteinaemia without disturbance of the carbohydrate metabolism.

Clofibrate↗