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Biomedical subjects

J Schreiner-Hecheltjen

Publications and source records attributed to J Schreiner-Hecheltjen.

3 recordsLinked to original sources
PubMed1980

[The influence of arterial partial pressure of CO2 and of the arterial value of pH on the oxygen consumption of the whole body during extracorporal circulation (author's transl)].

134 patients with coronary heart disease, with defects of the cardiac values or with inborn heart diseases were studied referring to the influences of the arterial partial pressure of CO2 and the arterial value of pH on oxygen consumption of the whole body during total hypothermic extracorporal circulation. Oxygen consumption of the whole body increases during respiratory or metabolic alkalosis whereas respiratory or metabolic acidosis decreases oxygen consumption significantly. These typical changes of oxygen consumption of the whole body during extraorporal circulation due to alkalosis or acidosis may be explained by different facts. Within the cellular area glycolysis is in relation of value for pH, and phosphofructokinase-reaction slows up due to ATP-level also in relationship of value for pH. In addition to cellular parameters hemodynamic parameters may explain the changes of oxygen consumption due to alkalosis and acidosis. Alkalosis effects a decrease of the total peripheral resistane whereas acidosis effects an increase of the total peripheral resistance. Peripheral oxygen consumption vaires in addition to other parameters in inverse proportion of the level of totalperipheral resistance.

Acid-Base Equilibrium↗
PubMed1980

[The influence of arterial partial pressure of co2 and of the arterial value of ph on endogenous catecholamines during extracorporal circulation in regard to oxygen consumption of the whole body (author's transl)].

Ten patients with coronary heart diseases were studied during total hypothermic extracorporal circulation relating changes of the endogenous catecholamines epinephrine and nor-epinephrine to arterial partial pressure of CO2 and to the arterial value of pH. Both of the catecholamines increased significantly during respiratory or metabolic acidosis whereas respiratory or metabolic alkalosis was accompanied by significantly lower catecholamine levels in blood. The changes in total peripheral resistance due to the endogenous blood levels of catecholamines depended proprotionally. Total peripheral resistance increased significantly due to increasing arterial level of both of the catecholamines. The results are discussed in consideration of oxygen consumption of the whole body during extracorporal circulation. It is known that the decrease of oxygen consumption of the whole body due to acidosis and due to an increased total peripheral resistance is accompanied by high catecholamine levels in blood. Increased hypothermic sympatho-adrenal activity during extracorporal circulation should not in any case cause in increase of oxygen consumption of the whole body.

Acidosis↗