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Biomedical subjects

J Schofield

Publications and source records attributed to J Schofield.

5 recordsLinked to original sources
PubMed1992

Preoperative radiotherapy for initially inoperable extremity soft tissue sarcomas.

The results and complications of a combination of preoperative radiotherapy and surgery in the treatment of 70 patients with large or fixed extremity soft tissue sarcomas are reported. Sixty-one patients were referred with a primary tumour and 9 had recurrences. Thirty-three patients had tumours in the thigh and 38 tumours were fixed to neighbouring structures. The mean preoperative dose was 53 Gy (range 21-75). Eleven patients received a postoperative boost to tumour site. Four patients received preoperative intra-arterial Adriamycin. Overall, 42 patients (60%) responded to the radiotherapy, 4 with complete tumour resolution. Eighty per cent of those receiving greater than or equal to 60 Gy responded and a significant correlation between 2 Gy equivalent dose and response was demonstrated (P less than 0.005). The degree of tumour necrosis was increased in 23 of 52 evaluable patients following radiotherapy, although there was no correlation with dose or clinical response. There have been eight local recurrences and 17 deaths after a median follow-up of 2 years. Tumour size less than 10 cm was the only significant factor in the development of local recurrence (P = 0.04). Thirty-six patients developed immediate postoperative complications: 9 major (13%), 13 moderate (19%) and 14 minor (20%). Increasing patient age was the only significant independent factor for the development of complications (P = 0.015). Preoperative radiotherapy will usually permit limb conservation of extremity sarcomas which otherwise would be inoperable or require amputation. However, the increased incidence of wound complications in older patients demands meticulous technique.

Adolescent↗
PubMed1989

Severe pulmonary hypertension in Ullrich-Noonan syndrome.

A 19 year old woman with Ullrich-Noonan syndrome presented with a six month history of progressive dyspnoea and cyanosis. Clinical features were suggestive of severe pulmonary hypertension. Cross sectional echocardiography showed pronounced right ventricular pressure overload with right ventricular hypertrophy. Cardiac catheterisation confirmed severe pulmonary hypertension. Attempts to reduce pulmonary artery pressure with calcium channel blockers were unsuccessful. The patient died shortly after investigation. Necropsy confirmed primary pulmonary hypertension.

Adult↗
PubMed1986

Computer monitoring, capture and analysis of gas/liquid chromatograph traces.

The work described here is effectively the computerization of a gas/liquid chromatograph of the pen recorder type using a BBC microcomputer. The output from the g.l.c. can be captured by the computer in accordance with a series of parameters. The sampling rate can be altered, as can an averaging facility to reduce noise, and a threshold level to eliminate the storage of irrelevant and space-consuming data. The unprocessed readings are initially stored on the computer's floppy disk, then later retrieved and cut into smaller sections to allow maximum resolution for on-screen analysis. In the main analysis stage of the system all processing is shown graphically on the computer monitor at all stages. The principal steps in analysis involve the mathematical modelling and elimination of the solvent peak, the fixing of the retention time for each subsequent peak and its disentangling from any following peaks, and finally the calculation of the area under each individual peak. Several alternative methods are made available for disentangling peaks, which can be tried successively on a single peak then each printed out with comments for comparison later. All readings and results in table form and screen dumps of all trace images are available via a dot matrix printer.

Algorithms↗